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The long-acting β2 -adrenoceptor agonist olodaterol attenuates pulmonary inflammation.

Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P - Br. J. Pharmacol. (2015)

Bottom Line: Besides their bronchodilatory effect, several studies suggest inhibitory effects on various aspects of inflammation.These anti-inflammatory effects were observed at doses relevant to their bronchodilatory efficacy.Furthermore, the in vivo data suggest that the anti-inflammatory properties of olodaterol are maintained after repeated dosing for 4 days.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

No MeSH data available.


Related in: MedlinePlus

Effect of olodaterol on CS-induced lung inflammation in Dunkin–Hartley guinea pigs. (A) Total, (B) neutrophilic and (C) monocytic cell counts in the BAL fluid of guinea pigs after CS exposure on 4 consecutive days. Olodaterol was administered intranasally 1 h before every CS exposure. Data shown are means ± SEM (n = 9–10 animals per group). **P < 0.01, ***P < 0.001; significantly different from CS-exposed, vehicle-treated animals.
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fig03: Effect of olodaterol on CS-induced lung inflammation in Dunkin–Hartley guinea pigs. (A) Total, (B) neutrophilic and (C) monocytic cell counts in the BAL fluid of guinea pigs after CS exposure on 4 consecutive days. Olodaterol was administered intranasally 1 h before every CS exposure. Data shown are means ± SEM (n = 9–10 animals per group). **P < 0.01, ***P < 0.001; significantly different from CS-exposed, vehicle-treated animals.

Mentions: The anti-inflammatory efficacy of olodaterol was also tested in a guinea pig model of CS-induced pulmonary inflammation to exclude the possibility that the anti-inflammatory mechanism was species-specific. Guinea pigs were exposed to CS on 4 consecutive days and olodaterol was administered intranasally 1 h prior to each CS exposure. CS induced a significant increase in neutrophilic and monocytic cell counts in the BAL of CS-exposed animals (Figure 3). CS increased the total BAL cell count, to about three-fold that from air-exposed animals (Figure 3A). CS induced the most prominent increase in BAL neutrophils (Figure 3B). Treatment with 10 μg·kg−1 olodaterol markedly reduced the total (Figure 3A) and neutrophil (Figure 3B) cell count. In contrast to the mouse model, monocytic cells were also significantly increased and all three doses of olodaterol reduced the monocytic cell accumulation with a maximal effect at 1 μg·kg−1 olodaterol (Figure 3C).


The long-acting β2 -adrenoceptor agonist olodaterol attenuates pulmonary inflammation.

Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P - Br. J. Pharmacol. (2015)

Effect of olodaterol on CS-induced lung inflammation in Dunkin–Hartley guinea pigs. (A) Total, (B) neutrophilic and (C) monocytic cell counts in the BAL fluid of guinea pigs after CS exposure on 4 consecutive days. Olodaterol was administered intranasally 1 h before every CS exposure. Data shown are means ± SEM (n = 9–10 animals per group). **P < 0.01, ***P < 0.001; significantly different from CS-exposed, vehicle-treated animals.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507158&req=5

fig03: Effect of olodaterol on CS-induced lung inflammation in Dunkin–Hartley guinea pigs. (A) Total, (B) neutrophilic and (C) monocytic cell counts in the BAL fluid of guinea pigs after CS exposure on 4 consecutive days. Olodaterol was administered intranasally 1 h before every CS exposure. Data shown are means ± SEM (n = 9–10 animals per group). **P < 0.01, ***P < 0.001; significantly different from CS-exposed, vehicle-treated animals.
Mentions: The anti-inflammatory efficacy of olodaterol was also tested in a guinea pig model of CS-induced pulmonary inflammation to exclude the possibility that the anti-inflammatory mechanism was species-specific. Guinea pigs were exposed to CS on 4 consecutive days and olodaterol was administered intranasally 1 h prior to each CS exposure. CS induced a significant increase in neutrophilic and monocytic cell counts in the BAL of CS-exposed animals (Figure 3). CS increased the total BAL cell count, to about three-fold that from air-exposed animals (Figure 3A). CS induced the most prominent increase in BAL neutrophils (Figure 3B). Treatment with 10 μg·kg−1 olodaterol markedly reduced the total (Figure 3A) and neutrophil (Figure 3B) cell count. In contrast to the mouse model, monocytic cells were also significantly increased and all three doses of olodaterol reduced the monocytic cell accumulation with a maximal effect at 1 μg·kg−1 olodaterol (Figure 3C).

Bottom Line: Besides their bronchodilatory effect, several studies suggest inhibitory effects on various aspects of inflammation.These anti-inflammatory effects were observed at doses relevant to their bronchodilatory efficacy.Furthermore, the in vivo data suggest that the anti-inflammatory properties of olodaterol are maintained after repeated dosing for 4 days.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

No MeSH data available.


Related in: MedlinePlus