Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1).
Bottom Line: Moreover, the affects of γ-catenin on cell migration were observed to be p53-dependent.Mechanistically, the anti-migratory effects seen via γ-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.Taken together, we identify γ-catenin as a novel regulator of HAI-1, which is a critical regulator of HGF/c-MET signaling.
Affiliation: From the Cancer Biology Program and.Show MeSH
Related in: MedlinePlus
Mentions: To further explore the p53-dependent effects of γ-catenin on cell proliferation and cell migration, we utilized short hairpin RNA (shRNA) or short interference RNAs (siRNAs) against p53. Interestingly, expression of γ-catenin failed to induce anti-proliferative (Fig. 2A), and anti-migratory (Fig. 2B) effects in p53 siRNA or p53 shRNA treated H157 cells, suggesting that the effects of γ-catenin were indeed p53-dependent.