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Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer.

Yang X, Hao J, Zhu CH, Niu YY, Ding XL, Liu C, Wu XZ - Medicine (Baltimore) (2015)

Bottom Line: Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors.Cox regression analysis suggested that elevated CA19-9 levels (P = 0.048), number of cycles of chemotherapy (P = 0.014), and TCM were independent prognostic factors (P < 0.001).The survival hazards ratio of TCM was 0.419 (95% confidence interval [CI], 0.261-0.671).The median overall survival (OS) was 19 months for patients with TCM treatment, while the median OS was 8 months for those without TCM treatment (P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: From Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China (XY, JH, Y-YN, X-LD, X-ZW); Zhong-Shan-Men In-Patient Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (C-HZ, CL).

ABSTRACT
Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in the treatment of patients with cancer worldwide. However, the clinical effect of TCM on patients with pancreatic cancer remains unclear. This study was aimed to explore the efficacy of TCM on selected patients with pancreatic cancer and to study the usefulness of multimodality treatment, including TCM and western medicine (WM), in pancreatic cancer.From January 2009 to October 2013, 107 patients with pancreatic cancer were included in this study. Kaplan-Meier curves were used to assess the differences in survival time. Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors.Cox regression analysis suggested that elevated CA19-9 levels (P = 0.048), number of cycles of chemotherapy (P = 0.014), and TCM were independent prognostic factors (P < 0.001). The survival hazards ratio of TCM was 0.419 (95% confidence interval [CI], 0.261-0.671). The median overall survival (OS) was 19 months for patients with TCM treatment, while the median OS was 8 months for those without TCM treatment (P < 0.001). Patients who received multimodality treatment using TCM and WM had the best prognosis with a median OS of 19 months (P < 0.001). Patients with heat-clearing, diuresis-promoting and detoxification TCM treatment had a longer survival time (32.4 months) than those with blood-activating and stasis-dissolving (9.8 months) and tonifying qi and yang treatment (6.1 months; P = 0.008).These results indicate that TCM has an important potential value for improving the prognosis of patients with pancreatic cancer, and multimodality treatment, including TCM and WM, leads to the best prognosis. More importantly, we suggest that heat-clearing, diuresis-promoting, and detoxification TCM treatment may improve the efficacy of TCM in pancreatic cancer.

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Related in: MedlinePlus

Forty-five types of herbs with a frequency >10.0%. (1) Radix Phytolaccae, (2) Semen Coicis, (3) Radix Scutellariae, (4) Gecko, (5) Herba Artemisiae Scopariae, (6) Radix Aucklandiae, (7) Radix Notoginseng, (8) Solanum nigrum L. (9) Fructus Meliae Toosendan, (10) Fructus Hordei Germinatus, (11) Fructus Akebiae, (12) Radix Curcumae, (13) Herba Pogostemonis, (14) Rhizoma Bolbostemmatis, (15) Rhizoma Pinelliae Preparatum, (16) Fructus Ammomi Rotundus, (17) Fructus Lycii, (18) Alumen, (19) Carapax Trionycis, (20) Rhizoma Arisaematis Cum Bile, (21) Endothelium Corneum Gigeriae Galli, (22) Radix Paeoniae Alba, (23) Sarcandra glabra (Thunb.) Nakai, (24) Cortex Magnoliae Officinalis, (25) Pericarpium Arecae, (26) Radix Glycyrrhizae, (27) Faeces Togopteri, (28) Radix Bupleuri, (29) Salvia chinensis Benth, (30) Bulbus Fritillariae Thunbergii, (31) Radix Trichosanthis, (32) Rhizoma Corydalis, (33) Talcum, (34) Rhizoma Cyperi, (35) Spora Lygodii, (36) Bulbus Lilii, (37) Herba Hedyotis, (38) Herba Taraxaci, (39) Radix Cynanchi Paniculati, (40) Radix Angelicae Sinensis, (41) Fructus Amomi Villosi, (42) Radix Scrophulariae, (43) Rhizoma Curcumae Longae, (44) Rhizoma Arisaematis, and (45) Actinidia valvata Dunn.
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Figure 2: Forty-five types of herbs with a frequency >10.0%. (1) Radix Phytolaccae, (2) Semen Coicis, (3) Radix Scutellariae, (4) Gecko, (5) Herba Artemisiae Scopariae, (6) Radix Aucklandiae, (7) Radix Notoginseng, (8) Solanum nigrum L. (9) Fructus Meliae Toosendan, (10) Fructus Hordei Germinatus, (11) Fructus Akebiae, (12) Radix Curcumae, (13) Herba Pogostemonis, (14) Rhizoma Bolbostemmatis, (15) Rhizoma Pinelliae Preparatum, (16) Fructus Ammomi Rotundus, (17) Fructus Lycii, (18) Alumen, (19) Carapax Trionycis, (20) Rhizoma Arisaematis Cum Bile, (21) Endothelium Corneum Gigeriae Galli, (22) Radix Paeoniae Alba, (23) Sarcandra glabra (Thunb.) Nakai, (24) Cortex Magnoliae Officinalis, (25) Pericarpium Arecae, (26) Radix Glycyrrhizae, (27) Faeces Togopteri, (28) Radix Bupleuri, (29) Salvia chinensis Benth, (30) Bulbus Fritillariae Thunbergii, (31) Radix Trichosanthis, (32) Rhizoma Corydalis, (33) Talcum, (34) Rhizoma Cyperi, (35) Spora Lygodii, (36) Bulbus Lilii, (37) Herba Hedyotis, (38) Herba Taraxaci, (39) Radix Cynanchi Paniculati, (40) Radix Angelicae Sinensis, (41) Fructus Amomi Villosi, (42) Radix Scrophulariae, (43) Rhizoma Curcumae Longae, (44) Rhizoma Arisaematis, and (45) Actinidia valvata Dunn.

Mentions: Patients with the same disease may have different TCM syndromes. Here, we wanted to analyze whether different principles of TCM treatment were associated with the prognosis of patients with pancreatic cancer. We analyzed the TCM formulas of 40 patients, who received 7701 days of TCM treatment and 165 types of herbs in total. The frequency of single-herb treatment was balanced by dividing the average treatment days and patient numbers. The frequency of single herbs over 10% is shown in Figure 2.


Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer.

Yang X, Hao J, Zhu CH, Niu YY, Ding XL, Liu C, Wu XZ - Medicine (Baltimore) (2015)

Forty-five types of herbs with a frequency >10.0%. (1) Radix Phytolaccae, (2) Semen Coicis, (3) Radix Scutellariae, (4) Gecko, (5) Herba Artemisiae Scopariae, (6) Radix Aucklandiae, (7) Radix Notoginseng, (8) Solanum nigrum L. (9) Fructus Meliae Toosendan, (10) Fructus Hordei Germinatus, (11) Fructus Akebiae, (12) Radix Curcumae, (13) Herba Pogostemonis, (14) Rhizoma Bolbostemmatis, (15) Rhizoma Pinelliae Preparatum, (16) Fructus Ammomi Rotundus, (17) Fructus Lycii, (18) Alumen, (19) Carapax Trionycis, (20) Rhizoma Arisaematis Cum Bile, (21) Endothelium Corneum Gigeriae Galli, (22) Radix Paeoniae Alba, (23) Sarcandra glabra (Thunb.) Nakai, (24) Cortex Magnoliae Officinalis, (25) Pericarpium Arecae, (26) Radix Glycyrrhizae, (27) Faeces Togopteri, (28) Radix Bupleuri, (29) Salvia chinensis Benth, (30) Bulbus Fritillariae Thunbergii, (31) Radix Trichosanthis, (32) Rhizoma Corydalis, (33) Talcum, (34) Rhizoma Cyperi, (35) Spora Lygodii, (36) Bulbus Lilii, (37) Herba Hedyotis, (38) Herba Taraxaci, (39) Radix Cynanchi Paniculati, (40) Radix Angelicae Sinensis, (41) Fructus Amomi Villosi, (42) Radix Scrophulariae, (43) Rhizoma Curcumae Longae, (44) Rhizoma Arisaematis, and (45) Actinidia valvata Dunn.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4504629&req=5

Figure 2: Forty-five types of herbs with a frequency >10.0%. (1) Radix Phytolaccae, (2) Semen Coicis, (3) Radix Scutellariae, (4) Gecko, (5) Herba Artemisiae Scopariae, (6) Radix Aucklandiae, (7) Radix Notoginseng, (8) Solanum nigrum L. (9) Fructus Meliae Toosendan, (10) Fructus Hordei Germinatus, (11) Fructus Akebiae, (12) Radix Curcumae, (13) Herba Pogostemonis, (14) Rhizoma Bolbostemmatis, (15) Rhizoma Pinelliae Preparatum, (16) Fructus Ammomi Rotundus, (17) Fructus Lycii, (18) Alumen, (19) Carapax Trionycis, (20) Rhizoma Arisaematis Cum Bile, (21) Endothelium Corneum Gigeriae Galli, (22) Radix Paeoniae Alba, (23) Sarcandra glabra (Thunb.) Nakai, (24) Cortex Magnoliae Officinalis, (25) Pericarpium Arecae, (26) Radix Glycyrrhizae, (27) Faeces Togopteri, (28) Radix Bupleuri, (29) Salvia chinensis Benth, (30) Bulbus Fritillariae Thunbergii, (31) Radix Trichosanthis, (32) Rhizoma Corydalis, (33) Talcum, (34) Rhizoma Cyperi, (35) Spora Lygodii, (36) Bulbus Lilii, (37) Herba Hedyotis, (38) Herba Taraxaci, (39) Radix Cynanchi Paniculati, (40) Radix Angelicae Sinensis, (41) Fructus Amomi Villosi, (42) Radix Scrophulariae, (43) Rhizoma Curcumae Longae, (44) Rhizoma Arisaematis, and (45) Actinidia valvata Dunn.
Mentions: Patients with the same disease may have different TCM syndromes. Here, we wanted to analyze whether different principles of TCM treatment were associated with the prognosis of patients with pancreatic cancer. We analyzed the TCM formulas of 40 patients, who received 7701 days of TCM treatment and 165 types of herbs in total. The frequency of single-herb treatment was balanced by dividing the average treatment days and patient numbers. The frequency of single herbs over 10% is shown in Figure 2.

Bottom Line: Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors.Cox regression analysis suggested that elevated CA19-9 levels (P = 0.048), number of cycles of chemotherapy (P = 0.014), and TCM were independent prognostic factors (P < 0.001).The survival hazards ratio of TCM was 0.419 (95% confidence interval [CI], 0.261-0.671).The median overall survival (OS) was 19 months for patients with TCM treatment, while the median OS was 8 months for those without TCM treatment (P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: From Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China (XY, JH, Y-YN, X-LD, X-ZW); Zhong-Shan-Men In-Patient Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (C-HZ, CL).

ABSTRACT
Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in the treatment of patients with cancer worldwide. However, the clinical effect of TCM on patients with pancreatic cancer remains unclear. This study was aimed to explore the efficacy of TCM on selected patients with pancreatic cancer and to study the usefulness of multimodality treatment, including TCM and western medicine (WM), in pancreatic cancer.From January 2009 to October 2013, 107 patients with pancreatic cancer were included in this study. Kaplan-Meier curves were used to assess the differences in survival time. Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors.Cox regression analysis suggested that elevated CA19-9 levels (P = 0.048), number of cycles of chemotherapy (P = 0.014), and TCM were independent prognostic factors (P < 0.001). The survival hazards ratio of TCM was 0.419 (95% confidence interval [CI], 0.261-0.671). The median overall survival (OS) was 19 months for patients with TCM treatment, while the median OS was 8 months for those without TCM treatment (P < 0.001). Patients who received multimodality treatment using TCM and WM had the best prognosis with a median OS of 19 months (P < 0.001). Patients with heat-clearing, diuresis-promoting and detoxification TCM treatment had a longer survival time (32.4 months) than those with blood-activating and stasis-dissolving (9.8 months) and tonifying qi and yang treatment (6.1 months; P = 0.008).These results indicate that TCM has an important potential value for improving the prognosis of patients with pancreatic cancer, and multimodality treatment, including TCM and WM, leads to the best prognosis. More importantly, we suggest that heat-clearing, diuresis-promoting, and detoxification TCM treatment may improve the efficacy of TCM in pancreatic cancer.

Show MeSH
Related in: MedlinePlus