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Epidemiological and Clinicopathological Trends of Breast Cancer in Chinese Patients During 1993 to 2013: A Retrospective Study.

Si W, Li Y, Han Y, Zhang F, Wang Y, Li Y, Linghu RX, Zhang X, Yang J - Medicine (Baltimore) (2015)

Bottom Line: The ratio of premenopausal women to postmenopausal women was 1.6 and no significant changes were found during the period (P = 0.121).The proportion of DCIS/LCIS and stage I increased with time during the 20 years from 14.6% to 33.2%, whereas the proportion of stage III to IV decreased.The proportion of Luminal A-like subtype gradually reduced and Luminal B-like (HER2-negative) increased and developed to the predominant type.Older age and earlier stage at diagnosis, as well as the alternation of predominant molecular subtypes, have become the developed trends of breast cancer.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Medical Oncology I, General Hospital of the Chinese People's Liberation Army, Beijing (WS, YH, FZ, YW, YL, RXL, XZ, JY); School of Medicine, Nankai University, Tianjin (WS, YH); and Department of Medical Oncology, Beijing Geriatric Hospital, Haidian District (YL).

ABSTRACT
This study aimed to summarize the epidemiological and pathological trends of breast cancer in Chinese women.The clinical data of 4968 breast cancer patients treated at the Chinese PLA General Hospital from 1993 to 2013 were retrospectively reviewed.The mean ± standard deviation (SD) age was 47.4 ± 11.3 years before the year 2001, 49.2 ± 11.2 years during 2001 to 2010, and 50.6 ± 11.4 years after the year 2010, respectively (P < 0.001). The ratio of premenopausal women to postmenopausal women was 1.6 and no significant changes were found during the period (P = 0.121). The proportion of patients with Scarff Bloom Richardson III breast cancer showed significant increase along with time (P = 0.015). The breast cancer was accounting for 31.7% at stage I and DCIS/LCIS and tend to be diagnosed with early stage around time (P < 0.001). The proportion of DCIS/LCIS and stage I increased with time during the 20 years from 14.6% to 33.2%, whereas the proportion of stage III to IV decreased.The proportion of Luminal A-like subtype gradually reduced and Luminal B-like (HER2-negative) increased and developed to the predominant type. Older age and earlier stage at diagnosis, as well as the alternation of predominant molecular subtypes, have become the developed trends of breast cancer.

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The proportions of SBR for patients with breast cancer in the study. SBR = Scarff Bloom Richardson.
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Figure 2: The proportions of SBR for patients with breast cancer in the study. SBR = Scarff Bloom Richardson.

Mentions: The histological grades of the common pathological types among the patients with breast cancer were listed in Table 2. Scarff Bloom Richardson (SBR) II was the main grade in all the common pathological type except for the medullary carcinoma (SBR III). In tubular carcinoma and mucinous carcinoma, the proportions of SBR III were low (15.4% and 0%, respectively), whereas the proportions of SBR I were higher in other types of carcinoma (38.5% and 35.7%, respectively). The proportion of patients with SBR III breast cancer showed significant increase along with time (P = 0.015) (Figure 2), whereas the proportion of special types (except for invasive ductal carcinoma and invasive lobular carcinoma) decreased in the early years. The proportion of invasion of regional lymph node differed significantly among the common pathological types of breast cancer (P < 0.001) (Table 3). Compared with invasive ductal carcinoma and invasive lobular carcinoma, patients with mucinous carcinoma and tubular carcinoma were at lower risk of lymph node metastasis, whereas those with micropapillary carcinoma were at higher risk for lymph node metastasis, respectively.


Epidemiological and Clinicopathological Trends of Breast Cancer in Chinese Patients During 1993 to 2013: A Retrospective Study.

Si W, Li Y, Han Y, Zhang F, Wang Y, Li Y, Linghu RX, Zhang X, Yang J - Medicine (Baltimore) (2015)

The proportions of SBR for patients with breast cancer in the study. SBR = Scarff Bloom Richardson.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4504600&req=5

Figure 2: The proportions of SBR for patients with breast cancer in the study. SBR = Scarff Bloom Richardson.
Mentions: The histological grades of the common pathological types among the patients with breast cancer were listed in Table 2. Scarff Bloom Richardson (SBR) II was the main grade in all the common pathological type except for the medullary carcinoma (SBR III). In tubular carcinoma and mucinous carcinoma, the proportions of SBR III were low (15.4% and 0%, respectively), whereas the proportions of SBR I were higher in other types of carcinoma (38.5% and 35.7%, respectively). The proportion of patients with SBR III breast cancer showed significant increase along with time (P = 0.015) (Figure 2), whereas the proportion of special types (except for invasive ductal carcinoma and invasive lobular carcinoma) decreased in the early years. The proportion of invasion of regional lymph node differed significantly among the common pathological types of breast cancer (P < 0.001) (Table 3). Compared with invasive ductal carcinoma and invasive lobular carcinoma, patients with mucinous carcinoma and tubular carcinoma were at lower risk of lymph node metastasis, whereas those with micropapillary carcinoma were at higher risk for lymph node metastasis, respectively.

Bottom Line: The ratio of premenopausal women to postmenopausal women was 1.6 and no significant changes were found during the period (P = 0.121).The proportion of DCIS/LCIS and stage I increased with time during the 20 years from 14.6% to 33.2%, whereas the proportion of stage III to IV decreased.The proportion of Luminal A-like subtype gradually reduced and Luminal B-like (HER2-negative) increased and developed to the predominant type.Older age and earlier stage at diagnosis, as well as the alternation of predominant molecular subtypes, have become the developed trends of breast cancer.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Medical Oncology I, General Hospital of the Chinese People's Liberation Army, Beijing (WS, YH, FZ, YW, YL, RXL, XZ, JY); School of Medicine, Nankai University, Tianjin (WS, YH); and Department of Medical Oncology, Beijing Geriatric Hospital, Haidian District (YL).

ABSTRACT
This study aimed to summarize the epidemiological and pathological trends of breast cancer in Chinese women.The clinical data of 4968 breast cancer patients treated at the Chinese PLA General Hospital from 1993 to 2013 were retrospectively reviewed.The mean ± standard deviation (SD) age was 47.4 ± 11.3 years before the year 2001, 49.2 ± 11.2 years during 2001 to 2010, and 50.6 ± 11.4 years after the year 2010, respectively (P < 0.001). The ratio of premenopausal women to postmenopausal women was 1.6 and no significant changes were found during the period (P = 0.121). The proportion of patients with Scarff Bloom Richardson III breast cancer showed significant increase along with time (P = 0.015). The breast cancer was accounting for 31.7% at stage I and DCIS/LCIS and tend to be diagnosed with early stage around time (P < 0.001). The proportion of DCIS/LCIS and stage I increased with time during the 20 years from 14.6% to 33.2%, whereas the proportion of stage III to IV decreased.The proportion of Luminal A-like subtype gradually reduced and Luminal B-like (HER2-negative) increased and developed to the predominant type. Older age and earlier stage at diagnosis, as well as the alternation of predominant molecular subtypes, have become the developed trends of breast cancer.

Show MeSH
Related in: MedlinePlus