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SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.

Kim TH, Ji YB, Song CM, Kim JY, Choi YY, Park JS, Tae K - World J Surg Oncol (2015)

Bottom Line: When stratified by tumor volume, the mean SUVmax was higher in malignant than in benign nodules in nodules≥1 cm3 (p<0.001).However, it did not differ between benign and malignant nodules smaller than 1 cm3.At a cut-off value of SUVmax of 6, the respective sensitivities of 18F-FDG PET/CT, ultrasonography, and fine needle aspiration cytology were 60.8, 96.4, and 99.1%, and the respective specificities were 95.9, 98.2, and 96.8%. 18F-FDG PET/CT is limited as a primary modality in the differential diagnosis of benign and malignant thyroid nodules because of its low sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-792, Korea. extradynamic@naver.com.

ABSTRACT

Background: The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed.

Methods: We studied 192 patients who underwent preoperative 18F-FDG PET/CT followed by thyroidectomy. We evaluated the correlation between the volume of thyroid nodules, 18F-FDG uptake on visual analysis, and the mean SUVmax measured on 18F-FDG PET/CT.

Results: When stratified by tumor volume, the mean SUVmax was higher in malignant than in benign nodules in nodules≥1 cm3 (p<0.001). However, it did not differ between benign and malignant nodules smaller than 1 cm3. At a cut-off value of SUVmax of 6, the respective sensitivities of 18F-FDG PET/CT, ultrasonography, and fine needle aspiration cytology were 60.8, 96.4, and 99.1%, and the respective specificities were 95.9, 98.2, and 96.8%.

Conclusions: 18F-FDG PET/CT is limited as a primary modality in the differential diagnosis of benign and malignant thyroid nodules because of its low sensitivity.

No MeSH data available.


Related in: MedlinePlus

Images of follicular carcinoma. a On ultrasonography, there is a 1.7-cm, hypoechoic nodule. b Focal, intense 18F-FDG uptake in the left isthmic nodule on 18F-FDG PET/CT (SUVmax = 11.97)
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Fig3: Images of follicular carcinoma. a On ultrasonography, there is a 1.7-cm, hypoechoic nodule. b Focal, intense 18F-FDG uptake in the left isthmic nodule on 18F-FDG PET/CT (SUVmax = 11.97)

Mentions: FNAC diagnosed 151 cases of malignancy or suspected malignancy, 35 benign cases, 4 cases classified as indeterminate, and 2 as inadequate. Of the 151 supposed malignancies, 1 was found to be benign after thyroidectomy. Of the four indeterminate cases, two were confirmed as follicular carcinomas and two as follicular adenomas (Figs. 2 and 3). The cases classified as inadequate were found to be nodular hyperplasia (Table 3).Fig. 2


SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.

Kim TH, Ji YB, Song CM, Kim JY, Choi YY, Park JS, Tae K - World J Surg Oncol (2015)

Images of follicular carcinoma. a On ultrasonography, there is a 1.7-cm, hypoechoic nodule. b Focal, intense 18F-FDG uptake in the left isthmic nodule on 18F-FDG PET/CT (SUVmax = 11.97)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4504214&req=5

Fig3: Images of follicular carcinoma. a On ultrasonography, there is a 1.7-cm, hypoechoic nodule. b Focal, intense 18F-FDG uptake in the left isthmic nodule on 18F-FDG PET/CT (SUVmax = 11.97)
Mentions: FNAC diagnosed 151 cases of malignancy or suspected malignancy, 35 benign cases, 4 cases classified as indeterminate, and 2 as inadequate. Of the 151 supposed malignancies, 1 was found to be benign after thyroidectomy. Of the four indeterminate cases, two were confirmed as follicular carcinomas and two as follicular adenomas (Figs. 2 and 3). The cases classified as inadequate were found to be nodular hyperplasia (Table 3).Fig. 2

Bottom Line: When stratified by tumor volume, the mean SUVmax was higher in malignant than in benign nodules in nodules≥1 cm3 (p<0.001).However, it did not differ between benign and malignant nodules smaller than 1 cm3.At a cut-off value of SUVmax of 6, the respective sensitivities of 18F-FDG PET/CT, ultrasonography, and fine needle aspiration cytology were 60.8, 96.4, and 99.1%, and the respective specificities were 95.9, 98.2, and 96.8%. 18F-FDG PET/CT is limited as a primary modality in the differential diagnosis of benign and malignant thyroid nodules because of its low sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-792, Korea. extradynamic@naver.com.

ABSTRACT

Background: The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed.

Methods: We studied 192 patients who underwent preoperative 18F-FDG PET/CT followed by thyroidectomy. We evaluated the correlation between the volume of thyroid nodules, 18F-FDG uptake on visual analysis, and the mean SUVmax measured on 18F-FDG PET/CT.

Results: When stratified by tumor volume, the mean SUVmax was higher in malignant than in benign nodules in nodules≥1 cm3 (p<0.001). However, it did not differ between benign and malignant nodules smaller than 1 cm3. At a cut-off value of SUVmax of 6, the respective sensitivities of 18F-FDG PET/CT, ultrasonography, and fine needle aspiration cytology were 60.8, 96.4, and 99.1%, and the respective specificities were 95.9, 98.2, and 96.8%.

Conclusions: 18F-FDG PET/CT is limited as a primary modality in the differential diagnosis of benign and malignant thyroid nodules because of its low sensitivity.

No MeSH data available.


Related in: MedlinePlus