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Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study.

Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L - NPJ Prim Care Respir Med (2015)

Bottom Line: Fifty-two (27.4%) of the patients were found to have ACOS.If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, Terveystalo Hospital, Turku, Finland.

ABSTRACT

Background: The overlap between asthma and chronic obstructive pulmonary disease (COPD) is an important clinical phenomenon. However, the prevalence of asthma-COPD overlap syndrome (ACOS) is not known.

Aims: To investigate the prevalence of ACOS among asthmatic patients with a smoking history, and evaluate the factors predicting ACOS in this patient group.

Methods: We investigated 190 primary care asthma patients with no previous diagnosis of COPD, but who were either current or ex-smokers, with a smoking history of at least 10 pack-years. Spirometry was performed on all the patients while they were taking their normal asthma medication. Patients were considered to have ACOS if their postbronchodilator forced expiratory volume in 1 s/forced vital capacity was < 0.70.

Results: Fifty-two (27.4%) of the patients were found to have ACOS. Age ⩾ 60 years and smoking for ⩾ 20 pack-years were the best predictors of ACOS. If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.

Conclusions: There is a high prevalence of ACOS among primary health care asthmatics with a positive smoking history but no previous diagnosis of COPD. In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

No MeSH data available.


Related in: MedlinePlus

Scatter plots and regression lines showing the association between age and pack-years versus postbronchodilator FEV1/FVC in 190 asthma patients with a positive smoking history. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
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fig2: Scatter plots and regression lines showing the association between age and pack-years versus postbronchodilator FEV1/FVC in 190 asthma patients with a positive smoking history. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.

Mentions: A negative correlation between postbronchodilator FEV1/FVC and age (Spearman Rho=−0.28, P<0.001) and pack-years (Rho=−0.25, P<0.001) was found (Figure 2).


Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study.

Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L - NPJ Prim Care Respir Med (2015)

Scatter plots and regression lines showing the association between age and pack-years versus postbronchodilator FEV1/FVC in 190 asthma patients with a positive smoking history. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4504195&req=5

fig2: Scatter plots and regression lines showing the association between age and pack-years versus postbronchodilator FEV1/FVC in 190 asthma patients with a positive smoking history. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
Mentions: A negative correlation between postbronchodilator FEV1/FVC and age (Spearman Rho=−0.28, P<0.001) and pack-years (Rho=−0.25, P<0.001) was found (Figure 2).

Bottom Line: Fifty-two (27.4%) of the patients were found to have ACOS.If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, Terveystalo Hospital, Turku, Finland.

ABSTRACT

Background: The overlap between asthma and chronic obstructive pulmonary disease (COPD) is an important clinical phenomenon. However, the prevalence of asthma-COPD overlap syndrome (ACOS) is not known.

Aims: To investigate the prevalence of ACOS among asthmatic patients with a smoking history, and evaluate the factors predicting ACOS in this patient group.

Methods: We investigated 190 primary care asthma patients with no previous diagnosis of COPD, but who were either current or ex-smokers, with a smoking history of at least 10 pack-years. Spirometry was performed on all the patients while they were taking their normal asthma medication. Patients were considered to have ACOS if their postbronchodilator forced expiratory volume in 1 s/forced vital capacity was < 0.70.

Results: Fifty-two (27.4%) of the patients were found to have ACOS. Age ⩾ 60 years and smoking for ⩾ 20 pack-years were the best predictors of ACOS. If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.

Conclusions: There is a high prevalence of ACOS among primary health care asthmatics with a positive smoking history but no previous diagnosis of COPD. In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

No MeSH data available.


Related in: MedlinePlus