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Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study.

Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L - NPJ Prim Care Respir Med (2015)

Bottom Line: Fifty-two (27.4%) of the patients were found to have ACOS.If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, Terveystalo Hospital, Turku, Finland.

ABSTRACT

Background: The overlap between asthma and chronic obstructive pulmonary disease (COPD) is an important clinical phenomenon. However, the prevalence of asthma-COPD overlap syndrome (ACOS) is not known.

Aims: To investigate the prevalence of ACOS among asthmatic patients with a smoking history, and evaluate the factors predicting ACOS in this patient group.

Methods: We investigated 190 primary care asthma patients with no previous diagnosis of COPD, but who were either current or ex-smokers, with a smoking history of at least 10 pack-years. Spirometry was performed on all the patients while they were taking their normal asthma medication. Patients were considered to have ACOS if their postbronchodilator forced expiratory volume in 1 s/forced vital capacity was < 0.70.

Results: Fifty-two (27.4%) of the patients were found to have ACOS. Age ⩾ 60 years and smoking for ⩾ 20 pack-years were the best predictors of ACOS. If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.

Conclusions: There is a high prevalence of ACOS among primary health care asthmatics with a positive smoking history but no previous diagnosis of COPD. In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

No MeSH data available.


Related in: MedlinePlus

Flow of participants. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
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fig1: Flow of participants. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.

Mentions: Two hundred and nineteen patients were recruited and 190 of them were included in the analysis (Figure 1). Their median age (range) was 58 (23–70) years, they had smoked for 20 (10–60) pack-years, and their body mass index was 27.5 (16.1–50.3) kg/m2. Eighty-three (44.1%) of the patients were current smokers and 112 (58.9%) were female.


Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study.

Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L - NPJ Prim Care Respir Med (2015)

Flow of participants. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4504195&req=5

fig1: Flow of participants. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
Mentions: Two hundred and nineteen patients were recruited and 190 of them were included in the analysis (Figure 1). Their median age (range) was 58 (23–70) years, they had smoked for 20 (10–60) pack-years, and their body mass index was 27.5 (16.1–50.3) kg/m2. Eighty-three (44.1%) of the patients were current smokers and 112 (58.9%) were female.

Bottom Line: Fifty-two (27.4%) of the patients were found to have ACOS.If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, Terveystalo Hospital, Turku, Finland.

ABSTRACT

Background: The overlap between asthma and chronic obstructive pulmonary disease (COPD) is an important clinical phenomenon. However, the prevalence of asthma-COPD overlap syndrome (ACOS) is not known.

Aims: To investigate the prevalence of ACOS among asthmatic patients with a smoking history, and evaluate the factors predicting ACOS in this patient group.

Methods: We investigated 190 primary care asthma patients with no previous diagnosis of COPD, but who were either current or ex-smokers, with a smoking history of at least 10 pack-years. Spirometry was performed on all the patients while they were taking their normal asthma medication. Patients were considered to have ACOS if their postbronchodilator forced expiratory volume in 1 s/forced vital capacity was < 0.70.

Results: Fifty-two (27.4%) of the patients were found to have ACOS. Age ⩾ 60 years and smoking for ⩾ 20 pack-years were the best predictors of ACOS. If both of these criteria were met, the odds ratio (95% confidence interval) for ACOS was 6.08 (2.11-17.49), compared with the situation where neither of these criteria were fulfilled.

Conclusions: There is a high prevalence of ACOS among primary health care asthmatics with a positive smoking history but no previous diagnosis of COPD. In this population, age over 60 years and a smoking history of more than 20 pack-years were the best predictors of ACOS.

No MeSH data available.


Related in: MedlinePlus