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Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress.

Tang M, Jiang P, Li H, Liu Y, Cai H, Dang R, Zhu W, Cao L - BMC Complement Altern Med (2015)

Bottom Line: Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system.Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China. tangmimi1989@163.com.

ABSTRACT

Background: Patients with major depressive disorder have a higher prevalence and incidence of dyslipidemia. However, clinical studies concerning the association between lipid levels and depression are inconsistent. Adipokines (like leptin and adiponectin) and ghrelin are strongly associated with lipid metabolism. Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system. In the present study, we investigated lipid metabolism in rats exposed to chronic unpredictable mild stress (CUMS) and the effect of fish oil on lipid profiles, aforementioned adipokines and ghrelin.

Methods: Sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effects of fish oil. After the behavior tests, peripheral blood were collected. Serum parameters, including fasting triglyceride (TG), total cholesterol (TCH), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), free fatty acid (FFA), glucose (GLU), adipokines (leptin, adiponectin) and ghrelin were assayed.

Results: After 5 weeks of CUMS procedures, rats were induced to depressive-like state, and exhibited increased serum levels of TCH, HDL-c, FFA and decreased serum levels of leptin and ghrelin, whereas the serum status of adiponectin, GLU, TG and LDL-c remained stable. Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.

Conclusions: Our results suggested that CUMS altered the serum levels of lipid profiles, leptin and ghrelin in rats. Fish oil supplementation not only provided antidepressant-like effects, but also reversed the altered lipid profiles and ghrelin level in serum. Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.

No MeSH data available.


Related in: MedlinePlus

Serum levels of lipid profiles and glucose. (A) Concentration of TG; (B) Concentration of TCH; (C) Concentration of HDL-c; (D) Concentration of LDL-c; (E) Concentration of FFA; (F) Concentration of GLU. Data are expressed as means ± SEM (n = 8).*P < 0.05, **P < 0.01 compared to control group. #P < 0.05, ##P < 0.01 compared to CUMS group
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Fig2: Serum levels of lipid profiles and glucose. (A) Concentration of TG; (B) Concentration of TCH; (C) Concentration of HDL-c; (D) Concentration of LDL-c; (E) Concentration of FFA; (F) Concentration of GLU. Data are expressed as means ± SEM (n = 8).*P < 0.05, **P < 0.01 compared to control group. #P < 0.05, ##P < 0.01 compared to CUMS group

Mentions: One day after the behavior tests, peripheral blood was collected. As shown in Fig. 2, CUMS significantly increased the serum levels of TCH (P < 0.05), HDL-c (P < 0.01) and FFA (P < 0.05), whereas TG and LDL-c remained stable. Fish oil supplementation restored CUMS-induced increase of serum TCH (P < 0.05) HDL-c (P < 0.05), FFA (P < 0.05), but sertraline treatment had no effect on TCH and HDL-c and signicantly increased the serum level of FFA both in control (P < 0.01) and CUMS (P < 0.05) rats. Meanwhile, the level of TG was significantly decreased by the treatment of fish oil (P < 0.01) and sertraline (P < 0.01) in CUMS rats.Fig. 2


Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress.

Tang M, Jiang P, Li H, Liu Y, Cai H, Dang R, Zhu W, Cao L - BMC Complement Altern Med (2015)

Serum levels of lipid profiles and glucose. (A) Concentration of TG; (B) Concentration of TCH; (C) Concentration of HDL-c; (D) Concentration of LDL-c; (E) Concentration of FFA; (F) Concentration of GLU. Data are expressed as means ± SEM (n = 8).*P < 0.05, **P < 0.01 compared to control group. #P < 0.05, ##P < 0.01 compared to CUMS group
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4504181&req=5

Fig2: Serum levels of lipid profiles and glucose. (A) Concentration of TG; (B) Concentration of TCH; (C) Concentration of HDL-c; (D) Concentration of LDL-c; (E) Concentration of FFA; (F) Concentration of GLU. Data are expressed as means ± SEM (n = 8).*P < 0.05, **P < 0.01 compared to control group. #P < 0.05, ##P < 0.01 compared to CUMS group
Mentions: One day after the behavior tests, peripheral blood was collected. As shown in Fig. 2, CUMS significantly increased the serum levels of TCH (P < 0.05), HDL-c (P < 0.01) and FFA (P < 0.05), whereas TG and LDL-c remained stable. Fish oil supplementation restored CUMS-induced increase of serum TCH (P < 0.05) HDL-c (P < 0.05), FFA (P < 0.05), but sertraline treatment had no effect on TCH and HDL-c and signicantly increased the serum level of FFA both in control (P < 0.01) and CUMS (P < 0.05) rats. Meanwhile, the level of TG was significantly decreased by the treatment of fish oil (P < 0.01) and sertraline (P < 0.01) in CUMS rats.Fig. 2

Bottom Line: Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system.Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China. tangmimi1989@163.com.

ABSTRACT

Background: Patients with major depressive disorder have a higher prevalence and incidence of dyslipidemia. However, clinical studies concerning the association between lipid levels and depression are inconsistent. Adipokines (like leptin and adiponectin) and ghrelin are strongly associated with lipid metabolism. Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system. In the present study, we investigated lipid metabolism in rats exposed to chronic unpredictable mild stress (CUMS) and the effect of fish oil on lipid profiles, aforementioned adipokines and ghrelin.

Methods: Sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effects of fish oil. After the behavior tests, peripheral blood were collected. Serum parameters, including fasting triglyceride (TG), total cholesterol (TCH), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), free fatty acid (FFA), glucose (GLU), adipokines (leptin, adiponectin) and ghrelin were assayed.

Results: After 5 weeks of CUMS procedures, rats were induced to depressive-like state, and exhibited increased serum levels of TCH, HDL-c, FFA and decreased serum levels of leptin and ghrelin, whereas the serum status of adiponectin, GLU, TG and LDL-c remained stable. Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.

Conclusions: Our results suggested that CUMS altered the serum levels of lipid profiles, leptin and ghrelin in rats. Fish oil supplementation not only provided antidepressant-like effects, but also reversed the altered lipid profiles and ghrelin level in serum. Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.

No MeSH data available.


Related in: MedlinePlus