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Clear cell sarcoma of the kidney with calcification and a novel chromosomal abnormality: a case report.

Kato M, Sato Y, Fukushima K, Okuya M, Kurosawa H, Kuwashima S, Honma K, Okamoto K, Tsuchioka T, Arisaka O - Diagn Pathol (2015)

Bottom Line: A pathological analysis of the resected tumor suggested clear cell sarcoma of the kidney (CCSK).Thus, this patient suffered atypical CCSK with significant calcification and gross necrosis.A novel chromosomal abnormality was also identified in the tumor.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Dokkyo Medical University, 880 Kita-Kobayashi, Mibu, Tochigi, 321-0293, Japan.

ABSTRACT
A 9-year-old male presented with a renal tumor that showed a cystic structure with calcification on computed tomography. A pathological analysis of the resected tumor suggested clear cell sarcoma of the kidney (CCSK). Thus, this patient suffered atypical CCSK with significant calcification and gross necrosis. A novel chromosomal abnormality was also identified in the tumor.

No MeSH data available.


Related in: MedlinePlus

Microscopic pathological analysis. Small oval cells arranged in nests or cords are separated by fibrovascular septa. Plump or spindle-shaped cells contain clear cytoplasm
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Fig3: Microscopic pathological analysis. Small oval cells arranged in nests or cords are separated by fibrovascular septa. Plump or spindle-shaped cells contain clear cytoplasm

Mentions: A 9-year-old boy complained of abdominal bloating. Blood parameters, including neuron specific enolase, alpha fetoprotein, and beta human chorionic gonadotropin, were in the normal ranges, and his urinary vanillylmandelic acid and homovanillic acid were not elevated. Unenhanced abdominal computed tomography (CT) revealed a tumor with calcification in the left kidney, with infiltration of the renal sinus and 15 cm wide (Fig. 1a). Contrast-enhanced CT revealed a heterogeneously enhancing mass completely enclosed by the renal capsule (Fig. 1b). No metastasis was detected in the lungs, liver, or bone by analysis of CT, magnetic resonance imaging and 99mTc scintigraphy. After complete surgical resection, the tumor showed heterogeneous pathological tissues divided by septa and included necrotic tissue (Fig. 2). Calcification was found around the necrotic tissue, but no macroscopic osteoplasty was observed. Pathological analysis suggested a monomorphic malignant neoplasm composed of plump or spindle-shaped cells with elongated, vesicular nuclei or small nuclei and variable amounts of clear cytoplasm (Fig. 3). These results prompted a diagnosis of stage 2 clear cell sarcoma of the kidney (CCSK).Fig. 1


Clear cell sarcoma of the kidney with calcification and a novel chromosomal abnormality: a case report.

Kato M, Sato Y, Fukushima K, Okuya M, Kurosawa H, Kuwashima S, Honma K, Okamoto K, Tsuchioka T, Arisaka O - Diagn Pathol (2015)

Microscopic pathological analysis. Small oval cells arranged in nests or cords are separated by fibrovascular septa. Plump or spindle-shaped cells contain clear cytoplasm
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4504129&req=5

Fig3: Microscopic pathological analysis. Small oval cells arranged in nests or cords are separated by fibrovascular septa. Plump or spindle-shaped cells contain clear cytoplasm
Mentions: A 9-year-old boy complained of abdominal bloating. Blood parameters, including neuron specific enolase, alpha fetoprotein, and beta human chorionic gonadotropin, were in the normal ranges, and his urinary vanillylmandelic acid and homovanillic acid were not elevated. Unenhanced abdominal computed tomography (CT) revealed a tumor with calcification in the left kidney, with infiltration of the renal sinus and 15 cm wide (Fig. 1a). Contrast-enhanced CT revealed a heterogeneously enhancing mass completely enclosed by the renal capsule (Fig. 1b). No metastasis was detected in the lungs, liver, or bone by analysis of CT, magnetic resonance imaging and 99mTc scintigraphy. After complete surgical resection, the tumor showed heterogeneous pathological tissues divided by septa and included necrotic tissue (Fig. 2). Calcification was found around the necrotic tissue, but no macroscopic osteoplasty was observed. Pathological analysis suggested a monomorphic malignant neoplasm composed of plump or spindle-shaped cells with elongated, vesicular nuclei or small nuclei and variable amounts of clear cytoplasm (Fig. 3). These results prompted a diagnosis of stage 2 clear cell sarcoma of the kidney (CCSK).Fig. 1

Bottom Line: A pathological analysis of the resected tumor suggested clear cell sarcoma of the kidney (CCSK).Thus, this patient suffered atypical CCSK with significant calcification and gross necrosis.A novel chromosomal abnormality was also identified in the tumor.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Dokkyo Medical University, 880 Kita-Kobayashi, Mibu, Tochigi, 321-0293, Japan.

ABSTRACT
A 9-year-old male presented with a renal tumor that showed a cystic structure with calcification on computed tomography. A pathological analysis of the resected tumor suggested clear cell sarcoma of the kidney (CCSK). Thus, this patient suffered atypical CCSK with significant calcification and gross necrosis. A novel chromosomal abnormality was also identified in the tumor.

No MeSH data available.


Related in: MedlinePlus