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Antioxidant and Antiproliferative Activities of the Essential Oils from Thymbra capitata and Thymus Species Grown in Portugal.

Miguel MG, Gago C, Antunes MD, Megías C, Cortés-Giraldo I, Vioque J, Lima AS, Figueiredo AC - Evid Based Complement Alternat Med (2015)

Bottom Line: The antioxidant and antiproliferative activities of the essential oils from Thymbra capitata and Thymus species grown in Portugal were evaluated.Thymbra and Thymus essential oils were grouped into two clusters: Cluster I in which carvacrol, thymol, p-cymene, α-terpineol, and γ-terpinene dominated and Cluster II in which thymol and carvacrol were absent and the main constituent was linalool.These results show the importance of these two terpene-phenolic compounds as antioxidants and cytotoxic agents against THP-1 cells.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Química e Farmácia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, MeditBio, Campus de Gambelas, 8005-139 Faro, Portugal.

ABSTRACT
The antioxidant and antiproliferative activities of the essential oils from Thymbra capitata and Thymus species grown in Portugal were evaluated. Thymbra and Thymus essential oils were grouped into two clusters: Cluster I in which carvacrol, thymol, p-cymene, α-terpineol, and γ-terpinene dominated and Cluster II in which thymol and carvacrol were absent and the main constituent was linalool. The ability for scavenging ABTS(•+) and peroxyl free radicals as well as for preventing the growth of THP-1 leukemia cells was better in essential oils with the highest contents of thymol and carvacrol. These results show the importance of these two terpene-phenolic compounds as antioxidants and cytotoxic agents against THP-1 cells.

No MeSH data available.


Related in: MedlinePlus

Antiproliferative activity of the essential oils on THP-1 cell line with 24 h exposure. The mean absorbance values for the negative control (DMSO treated cells) were standardized as 100% absorbance (i.e., no growth inhibition) and results were displayed as absorbance (% of control) versus essential oil concentration.
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fig2: Antiproliferative activity of the essential oils on THP-1 cell line with 24 h exposure. The mean absorbance values for the negative control (DMSO treated cells) were standardized as 100% absorbance (i.e., no growth inhibition) and results were displayed as absorbance (% of control) versus essential oil concentration.

Mentions: The MTT assay is a sensitive, simple, and reliable method for evaluating antiproliferative activity of plant-based products. The cytotoxic activities of the essential oils of Thymbra and Thymus species from Portugal were studied with the THP-1 leukemia cell line by treating these cells with increasing amounts of the essential oils for 24 and 96 h (Figures 2 and 3). In both cases, essential oils decreased viability of THP-1 cells in a dose-dependent manner.


Antioxidant and Antiproliferative Activities of the Essential Oils from Thymbra capitata and Thymus Species Grown in Portugal.

Miguel MG, Gago C, Antunes MD, Megías C, Cortés-Giraldo I, Vioque J, Lima AS, Figueiredo AC - Evid Based Complement Alternat Med (2015)

Antiproliferative activity of the essential oils on THP-1 cell line with 24 h exposure. The mean absorbance values for the negative control (DMSO treated cells) were standardized as 100% absorbance (i.e., no growth inhibition) and results were displayed as absorbance (% of control) versus essential oil concentration.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4503548&req=5

fig2: Antiproliferative activity of the essential oils on THP-1 cell line with 24 h exposure. The mean absorbance values for the negative control (DMSO treated cells) were standardized as 100% absorbance (i.e., no growth inhibition) and results were displayed as absorbance (% of control) versus essential oil concentration.
Mentions: The MTT assay is a sensitive, simple, and reliable method for evaluating antiproliferative activity of plant-based products. The cytotoxic activities of the essential oils of Thymbra and Thymus species from Portugal were studied with the THP-1 leukemia cell line by treating these cells with increasing amounts of the essential oils for 24 and 96 h (Figures 2 and 3). In both cases, essential oils decreased viability of THP-1 cells in a dose-dependent manner.

Bottom Line: The antioxidant and antiproliferative activities of the essential oils from Thymbra capitata and Thymus species grown in Portugal were evaluated.Thymbra and Thymus essential oils were grouped into two clusters: Cluster I in which carvacrol, thymol, p-cymene, α-terpineol, and γ-terpinene dominated and Cluster II in which thymol and carvacrol were absent and the main constituent was linalool.These results show the importance of these two terpene-phenolic compounds as antioxidants and cytotoxic agents against THP-1 cells.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Química e Farmácia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, MeditBio, Campus de Gambelas, 8005-139 Faro, Portugal.

ABSTRACT
The antioxidant and antiproliferative activities of the essential oils from Thymbra capitata and Thymus species grown in Portugal were evaluated. Thymbra and Thymus essential oils were grouped into two clusters: Cluster I in which carvacrol, thymol, p-cymene, α-terpineol, and γ-terpinene dominated and Cluster II in which thymol and carvacrol were absent and the main constituent was linalool. The ability for scavenging ABTS(•+) and peroxyl free radicals as well as for preventing the growth of THP-1 leukemia cells was better in essential oils with the highest contents of thymol and carvacrol. These results show the importance of these two terpene-phenolic compounds as antioxidants and cytotoxic agents against THP-1 cells.

No MeSH data available.


Related in: MedlinePlus