Limits...
Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.

Kim HW, Van Assche L, Jennings RB, Wince WB, Jensen CJ, Rehwald WG, Wendell DC, Bhatti L, Spatz DM, Parker MA, Jenista ER, Klem I, Crowley AL, Chen EL, Judd RM, Kim RJ - Circ. Res. (2015)

Bottom Line: Abnormal regions on MRI and pathology were compared by (a) quantitative measurement of the transmural-extent of the abnormality and (b) picture matching of contours.We found no relationship between the transmural-extent of T2-hyperintense regions and that of the AAR (bright-blood-T2: r=0.06, P=0.69; black-blood-T2: r=0.01, P=0.97).T2-weighted MRI does not depict the AAR.

View Article: PubMed Central - PubMed

Affiliation: From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.).

Show MeSH

Related in: MedlinePlus

A, A comparison between MRI and pathology at multiple short-axis levels in one subject with substantial salvage. The area-at-risk (AAR) by histopathology (top row, orange outline) is nearly 100% transmural at every short-axis location, whereas T2-hyperintense (third and fourth rows) and infarcted regions (second and bottom row) are clearly nontransmural (yellow arrows). The most basal slice shows a particularly large discrepancy between the full-thickness AAR and the region of infarction, which is tiny and subendocardial. For all slices, T2-hyperintense regions closely resemble the shape of infarction not the AAR. B, Zoomed-in views in a subject. The enlarged views emphasize the irregular contour of the infarcted region, which is matched by the contour of T2-hyperintensity on both bright-blood and black-blood images.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4503326&req=5

Figure 3: A, A comparison between MRI and pathology at multiple short-axis levels in one subject with substantial salvage. The area-at-risk (AAR) by histopathology (top row, orange outline) is nearly 100% transmural at every short-axis location, whereas T2-hyperintense (third and fourth rows) and infarcted regions (second and bottom row) are clearly nontransmural (yellow arrows). The most basal slice shows a particularly large discrepancy between the full-thickness AAR and the region of infarction, which is tiny and subendocardial. For all slices, T2-hyperintense regions closely resemble the shape of infarction not the AAR. B, Zoomed-in views in a subject. The enlarged views emphasize the irregular contour of the infarcted region, which is matched by the contour of T2-hyperintensity on both bright-blood and black-blood images.

Mentions: Figure 3A shows additional comparisons in one subject at multiple short-axis locations. At all locations, the shapes of T2-hyperintense regions match that of infarction, not the AAR, even when there are only tiny islands of subendocardial infarction (as shown in the most basal slice). Zoomed-in views in a subject are shown in Figure 3B. On the enlarged images, the intricate contour of the infarcted region is visible and observed to closely resemble that of T2-hyperintensity on both bright-blood and black-blood imaging. The contour of the AAR by histopathology is clearly different from that revealed by T2-hyperintensity.


Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.

Kim HW, Van Assche L, Jennings RB, Wince WB, Jensen CJ, Rehwald WG, Wendell DC, Bhatti L, Spatz DM, Parker MA, Jenista ER, Klem I, Crowley AL, Chen EL, Judd RM, Kim RJ - Circ. Res. (2015)

A, A comparison between MRI and pathology at multiple short-axis levels in one subject with substantial salvage. The area-at-risk (AAR) by histopathology (top row, orange outline) is nearly 100% transmural at every short-axis location, whereas T2-hyperintense (third and fourth rows) and infarcted regions (second and bottom row) are clearly nontransmural (yellow arrows). The most basal slice shows a particularly large discrepancy between the full-thickness AAR and the region of infarction, which is tiny and subendocardial. For all slices, T2-hyperintense regions closely resemble the shape of infarction not the AAR. B, Zoomed-in views in a subject. The enlarged views emphasize the irregular contour of the infarcted region, which is matched by the contour of T2-hyperintensity on both bright-blood and black-blood images.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4503326&req=5

Figure 3: A, A comparison between MRI and pathology at multiple short-axis levels in one subject with substantial salvage. The area-at-risk (AAR) by histopathology (top row, orange outline) is nearly 100% transmural at every short-axis location, whereas T2-hyperintense (third and fourth rows) and infarcted regions (second and bottom row) are clearly nontransmural (yellow arrows). The most basal slice shows a particularly large discrepancy between the full-thickness AAR and the region of infarction, which is tiny and subendocardial. For all slices, T2-hyperintense regions closely resemble the shape of infarction not the AAR. B, Zoomed-in views in a subject. The enlarged views emphasize the irregular contour of the infarcted region, which is matched by the contour of T2-hyperintensity on both bright-blood and black-blood images.
Mentions: Figure 3A shows additional comparisons in one subject at multiple short-axis locations. At all locations, the shapes of T2-hyperintense regions match that of infarction, not the AAR, even when there are only tiny islands of subendocardial infarction (as shown in the most basal slice). Zoomed-in views in a subject are shown in Figure 3B. On the enlarged images, the intricate contour of the infarcted region is visible and observed to closely resemble that of T2-hyperintensity on both bright-blood and black-blood imaging. The contour of the AAR by histopathology is clearly different from that revealed by T2-hyperintensity.

Bottom Line: Abnormal regions on MRI and pathology were compared by (a) quantitative measurement of the transmural-extent of the abnormality and (b) picture matching of contours.We found no relationship between the transmural-extent of T2-hyperintense regions and that of the AAR (bright-blood-T2: r=0.06, P=0.69; black-blood-T2: r=0.01, P=0.97).T2-weighted MRI does not depict the AAR.

View Article: PubMed Central - PubMed

Affiliation: From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.).

Show MeSH
Related in: MedlinePlus