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The Drosophila Prosecretory Transcription Factor dimmed Is Dynamically Regulated in Adult Enteroendocrine Cells and Protects Against Gram-Negative Infection.

Beebe K, Park D, Taghert PH, Micchelli CA - G3 (Bethesda) (2015)

Bottom Line: However, it remains unclear how this sensory epithelium responds to specific pathogenic challenges in a dynamic and regulated manner.We demonstrate that the enteroendocrine cells of the adult Drosophila melanogaster midgut display a transient, sensitive, and systemic induction of the prosecretory factor dimmed (dimm) in response to the Gram-negative pathogen Pseudomonas entomophila (Pe).We propose that dimm provides "gain" in enteroendocrine output during the adaptive response to episodic pathogen exposure.

View Article: PubMed Central - PubMed

Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110.

No MeSH data available.


Related in: MedlinePlus

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Mentions: We used the Drosophila midgut to investigate how the diffuse endocrine system responds to pathogenic infection by a Gram-negative bacterium. Our studies establish an important new link between pathogenic infection and the coordinated induction of a prosecretory program in cells of the diffuse endocrine system. They also suggest a molecular model explaining how changes in the lumenal environment might result in a dynamically altered organismal physiology (Figure 6). Mature enteroendocrine cells respond to the pathogenic bacterium Pe with induction of dimm, a prosecretory basic helix-loop-helix transcription factor. This response shows a defined signature in several variables, including time, dose and region of enteroendocrine induction. In the diffuse endocrine system, dimm is necessary for normal levels of the important peptide hormone AstA and an enzyme necessary for the processing of peptide hormones more generally. Thus, Dimm may function to provide “gain” in the adaptive response of the diffuse endocrine system (Mills and Taghert 2012). Finally, we show that dimm is an essential host factor that protects the organism against pathogenic challenge and controls the induction of antimicrobial peptides. Future studies will determine the extent to which changes in the diffuse endocrine system directly regulate immune function or whether these processes occur in parallel.


The Drosophila Prosecretory Transcription Factor dimmed Is Dynamically Regulated in Adult Enteroendocrine Cells and Protects Against Gram-Negative Infection.

Beebe K, Park D, Taghert PH, Micchelli CA - G3 (Bethesda) (2015)

Model.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4502385&req=5

fig6: Model.
Mentions: We used the Drosophila midgut to investigate how the diffuse endocrine system responds to pathogenic infection by a Gram-negative bacterium. Our studies establish an important new link between pathogenic infection and the coordinated induction of a prosecretory program in cells of the diffuse endocrine system. They also suggest a molecular model explaining how changes in the lumenal environment might result in a dynamically altered organismal physiology (Figure 6). Mature enteroendocrine cells respond to the pathogenic bacterium Pe with induction of dimm, a prosecretory basic helix-loop-helix transcription factor. This response shows a defined signature in several variables, including time, dose and region of enteroendocrine induction. In the diffuse endocrine system, dimm is necessary for normal levels of the important peptide hormone AstA and an enzyme necessary for the processing of peptide hormones more generally. Thus, Dimm may function to provide “gain” in the adaptive response of the diffuse endocrine system (Mills and Taghert 2012). Finally, we show that dimm is an essential host factor that protects the organism against pathogenic challenge and controls the induction of antimicrobial peptides. Future studies will determine the extent to which changes in the diffuse endocrine system directly regulate immune function or whether these processes occur in parallel.

Bottom Line: However, it remains unclear how this sensory epithelium responds to specific pathogenic challenges in a dynamic and regulated manner.We demonstrate that the enteroendocrine cells of the adult Drosophila melanogaster midgut display a transient, sensitive, and systemic induction of the prosecretory factor dimmed (dimm) in response to the Gram-negative pathogen Pseudomonas entomophila (Pe).We propose that dimm provides "gain" in enteroendocrine output during the adaptive response to episodic pathogen exposure.

View Article: PubMed Central - PubMed

Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110.

No MeSH data available.


Related in: MedlinePlus