Limits...
Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation.

Polovina MM, Ostojic MC, Potpara TS - Mediators Inflamm. (2015)

Bottom Line: Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n = 4; coronary artery disease, n = 1), P < 0.05.LAF patients developed VD more frequently and at a younger age.Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients.

View Article: PubMed Central - PubMed

Affiliation: Cardiology Clinic, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia ; School of Medicine, Belgrade University, Dr. Subotica 8, 11000 Belgrade, Serbia.

ABSTRACT
We compared plasma levels of biomarkers of inflammation (CRP) and oxidation (oxLDL), determined at study inclusion in lone atrial fibrillation (LAF) patients (48.6 ± 11.5 years; 74.0% men) and sinus rhythm controls (49.7 ± 9.3 years; 72.7% men, P > 0.05), and investigated the association of baseline CRP and oxLDL levels with the risk for vascular disease (VD) development (hypertension, cerebrovascular disease, coronary/peripheral artery disease, and pulmonary embolism) during prospective follow-up. Baseline CRP (1.2 [0.7-1.9] mg/L versus 1.1 [0.7-1.6] mg/L) and oxLDL levels (66.3 ± 21.2 U/L versus 57.1 ± 14.6 U/L) were higher in LAF patients (both P < 0.05). Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n = 4; coronary artery disease, n = 1), P < 0.05. LAF patients developed VD more frequently and at a younger age. Both CRP (HR, 2.54; 95% CI, 1.26-5.12; P = 0.009) and oxLDL (HR, 2.24; 95% CI, 1.14-4.40; P = 0.019) were multivariate predictors of incident hypertension in LAF patients, but not in the controls. Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients.

No MeSH data available.


Related in: MedlinePlus

The Kaplan-Meier curve of cumulative risk for vascular disease development in lone AF patients and healthy controls (logrank P = 0.014). VD: vascular disease.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4502325&req=5

fig1: The Kaplan-Meier curve of cumulative risk for vascular disease development in lone AF patients and healthy controls (logrank P = 0.014). VD: vascular disease.

Mentions: In the course of a median 36-month follow-up, incident vascular disease was diagnosed in 14 (28.0%) lone AF patients and in 5 (11.4%) healthy controls (Table 2). Arterial hypertension was the only vascular disorder diagnosed in lone AF patient group. None of the other overt vascular disorders (coronary/peripheral artery disease, significant carotid artery stenosis, pulmonary embolism, stroke, or TIA) occurred in lone AF patients. In the control group, 4 subjects developed arterial hypertension and 1 subject was diagnosed with coronary artery disease. None of the study participants died or were lost to follow-up. The median time to incident vascular disease was similar in both groups, but AF patients developed vascular disease at a younger age compared to healthy controls (Table 2). During follow-up, AF patients were treated with antiarrhythmic medications, beta-blockers, and non-dihydropyridine Ca2+ channel blockers, while vitamin K antagonists were prescribed for elective cardioversion (Table 2). One AF patient received aspirin for thromboprophylaxis. Control group patients received no cardiovascular medications except statins (Table 2). The Kaplan-Meier curve of the cumulative risk for vascular disease development in lone AF patients and healthy controls is presented in Figure 1.


Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation.

Polovina MM, Ostojic MC, Potpara TS - Mediators Inflamm. (2015)

The Kaplan-Meier curve of cumulative risk for vascular disease development in lone AF patients and healthy controls (logrank P = 0.014). VD: vascular disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4502325&req=5

fig1: The Kaplan-Meier curve of cumulative risk for vascular disease development in lone AF patients and healthy controls (logrank P = 0.014). VD: vascular disease.
Mentions: In the course of a median 36-month follow-up, incident vascular disease was diagnosed in 14 (28.0%) lone AF patients and in 5 (11.4%) healthy controls (Table 2). Arterial hypertension was the only vascular disorder diagnosed in lone AF patient group. None of the other overt vascular disorders (coronary/peripheral artery disease, significant carotid artery stenosis, pulmonary embolism, stroke, or TIA) occurred in lone AF patients. In the control group, 4 subjects developed arterial hypertension and 1 subject was diagnosed with coronary artery disease. None of the study participants died or were lost to follow-up. The median time to incident vascular disease was similar in both groups, but AF patients developed vascular disease at a younger age compared to healthy controls (Table 2). During follow-up, AF patients were treated with antiarrhythmic medications, beta-blockers, and non-dihydropyridine Ca2+ channel blockers, while vitamin K antagonists were prescribed for elective cardioversion (Table 2). One AF patient received aspirin for thromboprophylaxis. Control group patients received no cardiovascular medications except statins (Table 2). The Kaplan-Meier curve of the cumulative risk for vascular disease development in lone AF patients and healthy controls is presented in Figure 1.

Bottom Line: Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n = 4; coronary artery disease, n = 1), P < 0.05.LAF patients developed VD more frequently and at a younger age.Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients.

View Article: PubMed Central - PubMed

Affiliation: Cardiology Clinic, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia ; School of Medicine, Belgrade University, Dr. Subotica 8, 11000 Belgrade, Serbia.

ABSTRACT
We compared plasma levels of biomarkers of inflammation (CRP) and oxidation (oxLDL), determined at study inclusion in lone atrial fibrillation (LAF) patients (48.6 ± 11.5 years; 74.0% men) and sinus rhythm controls (49.7 ± 9.3 years; 72.7% men, P > 0.05), and investigated the association of baseline CRP and oxLDL levels with the risk for vascular disease (VD) development (hypertension, cerebrovascular disease, coronary/peripheral artery disease, and pulmonary embolism) during prospective follow-up. Baseline CRP (1.2 [0.7-1.9] mg/L versus 1.1 [0.7-1.6] mg/L) and oxLDL levels (66.3 ± 21.2 U/L versus 57.1 ± 14.6 U/L) were higher in LAF patients (both P < 0.05). Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n = 4; coronary artery disease, n = 1), P < 0.05. LAF patients developed VD more frequently and at a younger age. Both CRP (HR, 2.54; 95% CI, 1.26-5.12; P = 0.009) and oxLDL (HR, 2.24; 95% CI, 1.14-4.40; P = 0.019) were multivariate predictors of incident hypertension in LAF patients, but not in the controls. Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients.

No MeSH data available.


Related in: MedlinePlus