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Aortic ¹⁸F-FDG uptake in patients suffering from granulomatosis with polyangiitis.

Kemna MJ, Bucerius J, Drent M, Vöö S, Veenman M, van Paassen P, Tervaert JW, van Kroonenburgh MJ - Eur. J. Nucl. Med. Mol. Imaging (2015)

Bottom Line: The mean TBRmax was significantly higher in patients suffering from GPA or LVV compared to HC (p < 0.05 and p < 0.005, respectively) and tended to be higher in patients suffering from sarcoidosis, but this did not reach statistical significance (p = 0.098).In GPA patients, the mean TBRmax of the aorta was significantly higher in patients with previous renal involvement [2.01 (1.69-2.53)] compared to patients without renal involvement in the past [1.60 (1.51-1.80), p < 0.05].Patients suffering from GPA show marked aortic FDG uptake.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, The Netherlands.

ABSTRACT

Purpose: The objective of the study was to systematically assess aortic inflammation in patients with granulomatosis with polyangiitis (GPA) using (18)F-2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) positron emission tomography (PET)/CT.

Methods: Aortic inflammation was studied in PET/CT scans obtained from 21 patients with GPA; 14 patients with sarcoidosis were included as disease controls, 7 patients with stage I or II head and neck carcinoma ascertained during routine clinical practice were used as healthy controls (HC) and 5 patients with large vessel vasculitis (LVV) were used as positive controls. Aortic (18)F-FDG uptake was expressed as the blood-normalized maximum standardized uptake value (SUVmax), known as the target to background ratio (mean TBRmax).

Results: The mean TBRmax (interquartile range) of the aorta in patients with GPA, sarcoidosis, HC and LVV were 1.75 (1.32-2.05), 1.62 (1.54-1.74), 1.29 (1.22-1.52) and 2.03 (1.67-2.45), respectively. The mean TBRmax was significantly higher in patients suffering from GPA or LVV compared to HC (p < 0.05 and p < 0.005, respectively) and tended to be higher in patients suffering from sarcoidosis, but this did not reach statistical significance (p = 0.098). The mean TBRmax of the most diseased segment was significantly higher compared to HC [1.57 (1.39-1.81)] in LVV patients [2.55 (2.22-2.82), p < 0.005], GPA patients [2.17 (1.89-2.83), p < 0.005] and patients suffering from sarcoidosis [2.04 (1.88-2.20), p < 0.05]. In GPA patients, the mean TBRmax of the aorta was significantly higher in patients with previous renal involvement [2.01 (1.69-2.53)] compared to patients without renal involvement in the past [1.60 (1.51-1.80), p < 0.05]. Interrater reproducibility with a second reader was high (all intraclass correlation coefficients >0.9).

Conclusion: Patients suffering from GPA show marked aortic FDG uptake.

No MeSH data available.


Related in: MedlinePlus

Median TBR of SUVmax values of the most diseased segment of the aorta in patients with LVV, GPA, sarcoidosis and HC. The columns and brackets represent the median and IQR. *p < 0.05; **p < 0.005
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Fig2: Median TBR of SUVmax values of the most diseased segment of the aorta in patients with LVV, GPA, sarcoidosis and HC. The columns and brackets represent the median and IQR. *p < 0.05; **p < 0.005

Mentions: The median mean TBRmax of the most diseased segment was significantly higher compared to HC [1.57 (1.39–1.81)] in patients with LVV [2.55 (2.22–2.82), p < 0.005], patients with GPA [2.17 (1.89–2.83), p < 0.005] and patients with sarcoidosis [2.04 (1.88–2.20), p < 0.05, see Fig. 2].Fig. 2


Aortic ¹⁸F-FDG uptake in patients suffering from granulomatosis with polyangiitis.

Kemna MJ, Bucerius J, Drent M, Vöö S, Veenman M, van Paassen P, Tervaert JW, van Kroonenburgh MJ - Eur. J. Nucl. Med. Mol. Imaging (2015)

Median TBR of SUVmax values of the most diseased segment of the aorta in patients with LVV, GPA, sarcoidosis and HC. The columns and brackets represent the median and IQR. *p < 0.05; **p < 0.005
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4502318&req=5

Fig2: Median TBR of SUVmax values of the most diseased segment of the aorta in patients with LVV, GPA, sarcoidosis and HC. The columns and brackets represent the median and IQR. *p < 0.05; **p < 0.005
Mentions: The median mean TBRmax of the most diseased segment was significantly higher compared to HC [1.57 (1.39–1.81)] in patients with LVV [2.55 (2.22–2.82), p < 0.005], patients with GPA [2.17 (1.89–2.83), p < 0.005] and patients with sarcoidosis [2.04 (1.88–2.20), p < 0.05, see Fig. 2].Fig. 2

Bottom Line: The mean TBRmax was significantly higher in patients suffering from GPA or LVV compared to HC (p < 0.05 and p < 0.005, respectively) and tended to be higher in patients suffering from sarcoidosis, but this did not reach statistical significance (p = 0.098).In GPA patients, the mean TBRmax of the aorta was significantly higher in patients with previous renal involvement [2.01 (1.69-2.53)] compared to patients without renal involvement in the past [1.60 (1.51-1.80), p < 0.05].Patients suffering from GPA show marked aortic FDG uptake.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, The Netherlands.

ABSTRACT

Purpose: The objective of the study was to systematically assess aortic inflammation in patients with granulomatosis with polyangiitis (GPA) using (18)F-2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) positron emission tomography (PET)/CT.

Methods: Aortic inflammation was studied in PET/CT scans obtained from 21 patients with GPA; 14 patients with sarcoidosis were included as disease controls, 7 patients with stage I or II head and neck carcinoma ascertained during routine clinical practice were used as healthy controls (HC) and 5 patients with large vessel vasculitis (LVV) were used as positive controls. Aortic (18)F-FDG uptake was expressed as the blood-normalized maximum standardized uptake value (SUVmax), known as the target to background ratio (mean TBRmax).

Results: The mean TBRmax (interquartile range) of the aorta in patients with GPA, sarcoidosis, HC and LVV were 1.75 (1.32-2.05), 1.62 (1.54-1.74), 1.29 (1.22-1.52) and 2.03 (1.67-2.45), respectively. The mean TBRmax was significantly higher in patients suffering from GPA or LVV compared to HC (p < 0.05 and p < 0.005, respectively) and tended to be higher in patients suffering from sarcoidosis, but this did not reach statistical significance (p = 0.098). The mean TBRmax of the most diseased segment was significantly higher compared to HC [1.57 (1.39-1.81)] in LVV patients [2.55 (2.22-2.82), p < 0.005], GPA patients [2.17 (1.89-2.83), p < 0.005] and patients suffering from sarcoidosis [2.04 (1.88-2.20), p < 0.05]. In GPA patients, the mean TBRmax of the aorta was significantly higher in patients with previous renal involvement [2.01 (1.69-2.53)] compared to patients without renal involvement in the past [1.60 (1.51-1.80), p < 0.05]. Interrater reproducibility with a second reader was high (all intraclass correlation coefficients >0.9).

Conclusion: Patients suffering from GPA show marked aortic FDG uptake.

No MeSH data available.


Related in: MedlinePlus