Limits...
Research of Herb-Partitioned Moxibustion for Primary Dysmenorrhea Patients Based on the LC-MS Metabonomics.

Ma YX, Yang XY, Guo G, Du DQ, Yu YP, Gao SZ - Evid Based Complement Alternat Med (2015)

Bottom Line: The VAS of two groups decreased with different descending range.Discussion.It was effective in relieving the abdominal pain by these two therapies.

View Article: PubMed Central - PubMed

Affiliation: Shandong University of Traditional Chinese Medicine, Shandong 250355, China.

ABSTRACT
Objective. To explore the efficacy and mechanism of primary dysmenorrhea patients were treated with herb-partitioned moxibustion through metabonomics. Methods. 20 patients with primary dysmenorrhea were randomized into two groups, separately treated with herb-partitioned moxibustion at CV8 (shenque) and acupuncture at SP6 (sanyinjiao). After three menstrual cycles' treatment, the intensity of menstrual pain using VAS and the changes of metabolites of plasma using LC-MS were observed. Results. The VAS of two groups decreased with different descending range. Herb-partitioned moxibustion upregulated 20α-dihydroprogesterone, pregnenolone, prostaglandin E2 and γ-aminobutyric acid and downregulated the content of estrone and prostaglandin H2, while acupuncture upregulated pregnenolone and 20α-dihydroprogesterone and downregulated 2-methoxyestradiol-3-methylether, 15-hydroxyeicosatrienoic acid and 6-keto-prostaglandin. Discussion. It was effective in relieving the abdominal pain by these two therapies. Herb-partitioned moxibustion is superior to acupuncture for primary dysmenorrhea, which could be related to regulating the endocrine hormone.

No MeSH data available.


Related in: MedlinePlus

The TIA of two groups after treatment in ESI+ mode: (a) HPM group; (b) acupuncture group. Group HPM and group acupuncture had obvious differences.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4502312&req=5

fig4: The TIA of two groups after treatment in ESI+ mode: (a) HPM group; (b) acupuncture group. Group HPM and group acupuncture had obvious differences.

Mentions: The metabolomics figures of two groups were shown from Figures 4–7. Figures 4 and 5 show typical LC-MS total ion current (TIC) chromatograms of a plasma sample in positive ionization mode (Figure 4) and negative ionization mode (Figure 5). Compared to Figures 4(a) and 4(b), Figures 5(a) and 5(b), the TIC of group HPM and group acupuncture had obvious differences. In the PLS-DA plots (Figures 6 and 7), these two groups could also be well distinguished. Therefore, we deduced that the metabolite changes after treatment were different.


Research of Herb-Partitioned Moxibustion for Primary Dysmenorrhea Patients Based on the LC-MS Metabonomics.

Ma YX, Yang XY, Guo G, Du DQ, Yu YP, Gao SZ - Evid Based Complement Alternat Med (2015)

The TIA of two groups after treatment in ESI+ mode: (a) HPM group; (b) acupuncture group. Group HPM and group acupuncture had obvious differences.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4502312&req=5

fig4: The TIA of two groups after treatment in ESI+ mode: (a) HPM group; (b) acupuncture group. Group HPM and group acupuncture had obvious differences.
Mentions: The metabolomics figures of two groups were shown from Figures 4–7. Figures 4 and 5 show typical LC-MS total ion current (TIC) chromatograms of a plasma sample in positive ionization mode (Figure 4) and negative ionization mode (Figure 5). Compared to Figures 4(a) and 4(b), Figures 5(a) and 5(b), the TIC of group HPM and group acupuncture had obvious differences. In the PLS-DA plots (Figures 6 and 7), these two groups could also be well distinguished. Therefore, we deduced that the metabolite changes after treatment were different.

Bottom Line: The VAS of two groups decreased with different descending range.Discussion.It was effective in relieving the abdominal pain by these two therapies.

View Article: PubMed Central - PubMed

Affiliation: Shandong University of Traditional Chinese Medicine, Shandong 250355, China.

ABSTRACT
Objective. To explore the efficacy and mechanism of primary dysmenorrhea patients were treated with herb-partitioned moxibustion through metabonomics. Methods. 20 patients with primary dysmenorrhea were randomized into two groups, separately treated with herb-partitioned moxibustion at CV8 (shenque) and acupuncture at SP6 (sanyinjiao). After three menstrual cycles' treatment, the intensity of menstrual pain using VAS and the changes of metabolites of plasma using LC-MS were observed. Results. The VAS of two groups decreased with different descending range. Herb-partitioned moxibustion upregulated 20α-dihydroprogesterone, pregnenolone, prostaglandin E2 and γ-aminobutyric acid and downregulated the content of estrone and prostaglandin H2, while acupuncture upregulated pregnenolone and 20α-dihydroprogesterone and downregulated 2-methoxyestradiol-3-methylether, 15-hydroxyeicosatrienoic acid and 6-keto-prostaglandin. Discussion. It was effective in relieving the abdominal pain by these two therapies. Herb-partitioned moxibustion is superior to acupuncture for primary dysmenorrhea, which could be related to regulating the endocrine hormone.

No MeSH data available.


Related in: MedlinePlus