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Role of probiotics VSL#3 in prevention of suspected sepsis in low birthweight infants in India: a randomised controlled trial.

Sinha A, Gupta SS, Chellani H, Maliye C, Kumari V, Arya S, Garg BS, Gaur SD, Gaind R, Deotale V, Taywade M, Prasad MS, Thavraj V, Mukherjee A, Roy M - BMJ Open (2015)

Bottom Line: By intention-to-treat analysis, the risk of PSBI among infants in the overall population of LBW infants was not statistically significant (RR 0.79 (95% CI 0.56 to 1.03)).Probiotics reduced median days of hospitalisation (6 days vs 3 days in probiotics) (p=0.018) but not the risk of hospitalisation (RR 0.66 (95% CI 0.42 to 1.04).Daily supplementation of LBW infants with probiotics VSL#3 (10 billion cfu) for 30 days led to a non-significant 21% reduction in risk of neonatal sepsis.

View Article: PubMed Central - PubMed

Affiliation: Department of Reproductive and Child Health, Indian Council of Medical Research, New Delhi, Delhi, India.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curves for difference between event rates in the probiotic and placebo groups. PSBI, possible serious bacterial infection.
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BMJOPEN2014006564F2: Kaplan-Meier curves for difference between event rates in the probiotic and placebo groups. PSBI, possible serious bacterial infection.

Mentions: The Kaplan Meier survival analysis curves were plotted to compare the event rates in the probiotic and placebo arms (figure 2).This shows a divergence between the curves for probiotic and placebo, starting after a week of supplementation and remaining throughout the follow-up period. The onset of first episode of PSBI in 10% of infants occurred on the 41st day in the probiotic arm versus the 24th day in the control arm (p=0.063), and the onset of first episode of suspected sepsis diagnosed by the physician in 5% of infants occurred on the 53rd day in the probiotic arm versus the 26th day in the control arm (p=0.071).


Role of probiotics VSL#3 in prevention of suspected sepsis in low birthweight infants in India: a randomised controlled trial.

Sinha A, Gupta SS, Chellani H, Maliye C, Kumari V, Arya S, Garg BS, Gaur SD, Gaind R, Deotale V, Taywade M, Prasad MS, Thavraj V, Mukherjee A, Roy M - BMJ Open (2015)

Kaplan-Meier curves for difference between event rates in the probiotic and placebo groups. PSBI, possible serious bacterial infection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499724&req=5

BMJOPEN2014006564F2: Kaplan-Meier curves for difference between event rates in the probiotic and placebo groups. PSBI, possible serious bacterial infection.
Mentions: The Kaplan Meier survival analysis curves were plotted to compare the event rates in the probiotic and placebo arms (figure 2).This shows a divergence between the curves for probiotic and placebo, starting after a week of supplementation and remaining throughout the follow-up period. The onset of first episode of PSBI in 10% of infants occurred on the 41st day in the probiotic arm versus the 24th day in the control arm (p=0.063), and the onset of first episode of suspected sepsis diagnosed by the physician in 5% of infants occurred on the 53rd day in the probiotic arm versus the 26th day in the control arm (p=0.071).

Bottom Line: By intention-to-treat analysis, the risk of PSBI among infants in the overall population of LBW infants was not statistically significant (RR 0.79 (95% CI 0.56 to 1.03)).Probiotics reduced median days of hospitalisation (6 days vs 3 days in probiotics) (p=0.018) but not the risk of hospitalisation (RR 0.66 (95% CI 0.42 to 1.04).Daily supplementation of LBW infants with probiotics VSL#3 (10 billion cfu) for 30 days led to a non-significant 21% reduction in risk of neonatal sepsis.

View Article: PubMed Central - PubMed

Affiliation: Department of Reproductive and Child Health, Indian Council of Medical Research, New Delhi, Delhi, India.

No MeSH data available.


Related in: MedlinePlus