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Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project.

Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Münzel T, Konstantinides SV, Wild PS, VTEval study gro - BMJ Open (2015)

Bottom Line: Primary short-term outcome is defined by overall mortality (PE-related death and all other causes of death), primary long-term outcome by symptomatic VTE (PE-related death, recurrence of non-fatal PE or DVT).The VTEval Project includes three 'all-comer' studies and involves the standardised acquisition of high-quality data, covering the systematic assessment of VTE including symptoms, risk profile, psychosocial, environmental and lifestyle factors as well as clinical and subclinical disease, and it builds up a large state-of-the-art biorepository containing various materials from serial blood samplings.The VTEval Project has been approved by the local data safety commissioner and the responsible ethics committee (reference no. 837.320.12 (8421-F)).

View Article: PubMed Central - PubMed

Affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.

No MeSH data available.


Related in: MedlinePlus

(A) Definition for clinical suspicion of acute PE. PE, pulmonary embolism; RV, right ventricular. (B) Definition for clinical suspicion of acute DVT. DVT, deep vein thrombosis. (C) Definition for clinical suspicion of incidental VTE. DVT, deep vein thrombosis; PE, pulmonary embolism; VTE, venous thromboembolism.
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BMJOPEN2015008157F1: (A) Definition for clinical suspicion of acute PE. PE, pulmonary embolism; RV, right ventricular. (B) Definition for clinical suspicion of acute DVT. DVT, deep vein thrombosis. (C) Definition for clinical suspicion of incidental VTE. DVT, deep vein thrombosis; PE, pulmonary embolism; VTE, venous thromboembolism.

Mentions: Eligible patients are individuals with a clinical suspicion of acute PE (with or without DVT) (1), individuals with a clinical suspicion of acute DVT (without symptomatic PE) (2), and individuals with incidental diagnosis of VTE (PE or DVT) (3). The inclusion and exclusion criteria for clinically suspected and incidental diagnosis of VTE are given in figure 1A–C.910 Eligible individuals are recruited in all units/sections via which they present at the hospital, such as emergency rooms, chest pain units and outpatient clinics; patients are ≥18 years of age and must have provided informed consent.


Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project.

Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Münzel T, Konstantinides SV, Wild PS, VTEval study gro - BMJ Open (2015)

(A) Definition for clinical suspicion of acute PE. PE, pulmonary embolism; RV, right ventricular. (B) Definition for clinical suspicion of acute DVT. DVT, deep vein thrombosis. (C) Definition for clinical suspicion of incidental VTE. DVT, deep vein thrombosis; PE, pulmonary embolism; VTE, venous thromboembolism.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499722&req=5

BMJOPEN2015008157F1: (A) Definition for clinical suspicion of acute PE. PE, pulmonary embolism; RV, right ventricular. (B) Definition for clinical suspicion of acute DVT. DVT, deep vein thrombosis. (C) Definition for clinical suspicion of incidental VTE. DVT, deep vein thrombosis; PE, pulmonary embolism; VTE, venous thromboembolism.
Mentions: Eligible patients are individuals with a clinical suspicion of acute PE (with or without DVT) (1), individuals with a clinical suspicion of acute DVT (without symptomatic PE) (2), and individuals with incidental diagnosis of VTE (PE or DVT) (3). The inclusion and exclusion criteria for clinically suspected and incidental diagnosis of VTE are given in figure 1A–C.910 Eligible individuals are recruited in all units/sections via which they present at the hospital, such as emergency rooms, chest pain units and outpatient clinics; patients are ≥18 years of age and must have provided informed consent.

Bottom Line: Primary short-term outcome is defined by overall mortality (PE-related death and all other causes of death), primary long-term outcome by symptomatic VTE (PE-related death, recurrence of non-fatal PE or DVT).The VTEval Project includes three 'all-comer' studies and involves the standardised acquisition of high-quality data, covering the systematic assessment of VTE including symptoms, risk profile, psychosocial, environmental and lifestyle factors as well as clinical and subclinical disease, and it builds up a large state-of-the-art biorepository containing various materials from serial blood samplings.The VTEval Project has been approved by the local data safety commissioner and the responsible ethics committee (reference no. 837.320.12 (8421-F)).

View Article: PubMed Central - PubMed

Affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.

No MeSH data available.


Related in: MedlinePlus