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Differential Effects of Parietal and Cerebellar Stroke in Response to Object Location Perturbation.

Pelton TA, Wing AM, Fraser D, van Vliet P - Front Hum Neurosci (2015)

Bottom Line: To contrast impairments in reach-to-grasp coordination, in response to object location perturbation, in patients with right parietal and cerebellar lesions, in order to further elucidate the role of each area in reach-to-grasp coordination.Patients with parietal or cerebellar lesions showed some similar and some contrasting deficits.The cerebellum was more dominant in controlling temporal coupling between transport and grasp components, and the parietal area was more concerned with using sensation to relate arm and hand state to target position.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, College of Life and Environmental Sciences, University of Birmingham , Edgbaston , UK.

ABSTRACT

Background: The differential contributions of the cerebellum and parietal lobe to coordination between hand transport and hand shaping to an object have not been clearly identified.

Objective: To contrast impairments in reach-to-grasp coordination, in response to object location perturbation, in patients with right parietal and cerebellar lesions, in order to further elucidate the role of each area in reach-to-grasp coordination.

Method: A two-factor design with one between subject factor (right parietal stroke; cerebellar stroke; controls) and one within subject factor (presence or absence of object location perturbation) examined correction processes used to maintain coordination between transport-to-grasp in the presence of perturbation. Sixteen chronic stroke participants (eight with right parietal lesions and eight with cerebellar lesions) were matched in age (mean = 61 years; standard deviation = 12) and hand dominance with 16 healthy controls. Hand and arm movements were recorded during unperturbed baseline trials (10) and unpredictable trials (60) in which the target was displaced to the left (10) or right (10) or remained fixed (40).

Results: Cerebellar patients had a slowed response to perturbation with anticipatory hand opening, an increased number of aperture peaks and disruption to temporal coordination, and greater variability. Parietal participants also exhibited slowed movements, with increased number of aperture peaks, but in addition, increased the number of velocity peaks and had a longer wrist path trajectory due to difficulties planning the new transport goal and thus relying more on feedback control.

Conclusion: Patients with parietal or cerebellar lesions showed some similar and some contrasting deficits. The cerebellum was more dominant in controlling temporal coupling between transport and grasp components, and the parietal area was more concerned with using sensation to relate arm and hand state to target position.

No MeSH data available.


Related in: MedlinePlus

50° aperture onset relative to wrist onset. Mean (SE) effect of group (control, parietal, and cerebellar) and condition (baseline, unperturbed 30°, perturbed 10°, and perturbed 50°).
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Figure 4: 50° aperture onset relative to wrist onset. Mean (SE) effect of group (control, parietal, and cerebellar) and condition (baseline, unperturbed 30°, perturbed 10°, and perturbed 50°).

Mentions: With regard to the grasp component, there was a main effect (F2,29 = 3.902, p < 0.05) of group upon aperture onset time (Figure 4). The cerebellar group demonstrated an early aperture onset (M = −0.036 s, SE = 0.038) whereas for the parietal group it was relatively late (M = 0.115 s, SE = 0.038). Following the baseline trials, significant differences were found between the two stroke groups (baseline NS; unperturbed t14 = −2.338, p < 0.05; perturbed 10°t14 = −2.351, p < 0.05 and perturbed 50°t14 = −2.413, p < 0.05). There were no significant differences for either of the patient groups in comparison to controls (M = 0.049 s, SE = 0.027). Overall, the mean MA was similar between the control group (M = 57 mm, SE = 4) and the stroke patient groups (Parietal M = 65 mm, SE = 6 and Cerebellar M = 55 mm, SE = 6). There was a tendency for increased variability of MA in the parietal group (M = 15%, SE = 2.1) when compared to controls (M = 10%, SE = 0.7) during the unperturbed trials only.


Differential Effects of Parietal and Cerebellar Stroke in Response to Object Location Perturbation.

Pelton TA, Wing AM, Fraser D, van Vliet P - Front Hum Neurosci (2015)

50° aperture onset relative to wrist onset. Mean (SE) effect of group (control, parietal, and cerebellar) and condition (baseline, unperturbed 30°, perturbed 10°, and perturbed 50°).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499699&req=5

Figure 4: 50° aperture onset relative to wrist onset. Mean (SE) effect of group (control, parietal, and cerebellar) and condition (baseline, unperturbed 30°, perturbed 10°, and perturbed 50°).
Mentions: With regard to the grasp component, there was a main effect (F2,29 = 3.902, p < 0.05) of group upon aperture onset time (Figure 4). The cerebellar group demonstrated an early aperture onset (M = −0.036 s, SE = 0.038) whereas for the parietal group it was relatively late (M = 0.115 s, SE = 0.038). Following the baseline trials, significant differences were found between the two stroke groups (baseline NS; unperturbed t14 = −2.338, p < 0.05; perturbed 10°t14 = −2.351, p < 0.05 and perturbed 50°t14 = −2.413, p < 0.05). There were no significant differences for either of the patient groups in comparison to controls (M = 0.049 s, SE = 0.027). Overall, the mean MA was similar between the control group (M = 57 mm, SE = 4) and the stroke patient groups (Parietal M = 65 mm, SE = 6 and Cerebellar M = 55 mm, SE = 6). There was a tendency for increased variability of MA in the parietal group (M = 15%, SE = 2.1) when compared to controls (M = 10%, SE = 0.7) during the unperturbed trials only.

Bottom Line: To contrast impairments in reach-to-grasp coordination, in response to object location perturbation, in patients with right parietal and cerebellar lesions, in order to further elucidate the role of each area in reach-to-grasp coordination.Patients with parietal or cerebellar lesions showed some similar and some contrasting deficits.The cerebellum was more dominant in controlling temporal coupling between transport and grasp components, and the parietal area was more concerned with using sensation to relate arm and hand state to target position.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, College of Life and Environmental Sciences, University of Birmingham , Edgbaston , UK.

ABSTRACT

Background: The differential contributions of the cerebellum and parietal lobe to coordination between hand transport and hand shaping to an object have not been clearly identified.

Objective: To contrast impairments in reach-to-grasp coordination, in response to object location perturbation, in patients with right parietal and cerebellar lesions, in order to further elucidate the role of each area in reach-to-grasp coordination.

Method: A two-factor design with one between subject factor (right parietal stroke; cerebellar stroke; controls) and one within subject factor (presence or absence of object location perturbation) examined correction processes used to maintain coordination between transport-to-grasp in the presence of perturbation. Sixteen chronic stroke participants (eight with right parietal lesions and eight with cerebellar lesions) were matched in age (mean = 61 years; standard deviation = 12) and hand dominance with 16 healthy controls. Hand and arm movements were recorded during unperturbed baseline trials (10) and unpredictable trials (60) in which the target was displaced to the left (10) or right (10) or remained fixed (40).

Results: Cerebellar patients had a slowed response to perturbation with anticipatory hand opening, an increased number of aperture peaks and disruption to temporal coordination, and greater variability. Parietal participants also exhibited slowed movements, with increased number of aperture peaks, but in addition, increased the number of velocity peaks and had a longer wrist path trajectory due to difficulties planning the new transport goal and thus relying more on feedback control.

Conclusion: Patients with parietal or cerebellar lesions showed some similar and some contrasting deficits. The cerebellum was more dominant in controlling temporal coupling between transport and grasp components, and the parietal area was more concerned with using sensation to relate arm and hand state to target position.

No MeSH data available.


Related in: MedlinePlus