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A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus

Relationships between hypoxia, inflammation and iron homoeostasis, mediated by hepcidin (EPO, erythropoietin).
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BMJOPEN2015007911F7: Relationships between hypoxia, inflammation and iron homoeostasis, mediated by hepcidin (EPO, erythropoietin).

Mentions: In adult patients with another chronic inflammatory respiratory disorder, cystic fibrosis, an impaired erythropoietic response to hypoxaemia has also been described,33 apparently associated with inflammation, as in our COPD cohort. In a separate study, a 3-month course of oral iron was shown not to increase haemoglobin in a subgroup of patients with cystic fibrosis and functional iron deficiency (defined as TSat <16%).34 However, a very small case series of adult patients with cystic fibrosis given intravenous iron for anaemia refractory to oral iron found that haemoglobin concentration and MCV rose significantly within days of therapy.35 These findings are consistent with suppression of iron absorption by hepcidin. FigureĀ 7 gives a schematic representation of the influence of hepcidin in the setting of chronic inflammation.


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Relationships between hypoxia, inflammation and iron homoeostasis, mediated by hepcidin (EPO, erythropoietin).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499677&req=5

BMJOPEN2015007911F7: Relationships between hypoxia, inflammation and iron homoeostasis, mediated by hepcidin (EPO, erythropoietin).
Mentions: In adult patients with another chronic inflammatory respiratory disorder, cystic fibrosis, an impaired erythropoietic response to hypoxaemia has also been described,33 apparently associated with inflammation, as in our COPD cohort. In a separate study, a 3-month course of oral iron was shown not to increase haemoglobin in a subgroup of patients with cystic fibrosis and functional iron deficiency (defined as TSat <16%).34 However, a very small case series of adult patients with cystic fibrosis given intravenous iron for anaemia refractory to oral iron found that haemoglobin concentration and MCV rose significantly within days of therapy.35 These findings are consistent with suppression of iron absorption by hepcidin. FigureĀ 7 gives a schematic representation of the influence of hepcidin in the setting of chronic inflammation.

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus