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A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus

Box plots showing distribution of (A) Shuttle Walk Test (SWT) distance and (B) St George's Respiratory Questionnaire (SGRQ) score, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. SWT distance was lower in the iron-deficient (ID) group (median 165 vs 240 m, p=0.035) although statistical significance was lost after correction for difference in FEV1 (p=0.081). The difference in SGRQ scores was not statistically significant (mean 33.5 vs 30.1, p=0.056).
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BMJOPEN2015007911F6: Box plots showing distribution of (A) Shuttle Walk Test (SWT) distance and (B) St George's Respiratory Questionnaire (SGRQ) score, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. SWT distance was lower in the iron-deficient (ID) group (median 165 vs 240 m, p=0.035) although statistical significance was lost after correction for difference in FEV1 (p=0.081). The difference in SGRQ scores was not statistically significant (mean 33.5 vs 30.1, p=0.056).

Mentions: Exercise ability, as measured by the SWT, was worse in the ID group (median 165 vs 240 m, p=0.035; figure 6) but statistical significance was lost after adjusting for differences in FEV1 (p=0.081). Differences in SGRQ scores, HAD scores, and ESS between ID and IR groups, did not reach statistical significance (mean 33.5 vs 30.1, p=0.056; median 13.5 vs 11, p=0.133 and median 8 vs 5, p=0.279, respectively).


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Box plots showing distribution of (A) Shuttle Walk Test (SWT) distance and (B) St George's Respiratory Questionnaire (SGRQ) score, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. SWT distance was lower in the iron-deficient (ID) group (median 165 vs 240 m, p=0.035) although statistical significance was lost after correction for difference in FEV1 (p=0.081). The difference in SGRQ scores was not statistically significant (mean 33.5 vs 30.1, p=0.056).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499677&req=5

BMJOPEN2015007911F6: Box plots showing distribution of (A) Shuttle Walk Test (SWT) distance and (B) St George's Respiratory Questionnaire (SGRQ) score, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. SWT distance was lower in the iron-deficient (ID) group (median 165 vs 240 m, p=0.035) although statistical significance was lost after correction for difference in FEV1 (p=0.081). The difference in SGRQ scores was not statistically significant (mean 33.5 vs 30.1, p=0.056).
Mentions: Exercise ability, as measured by the SWT, was worse in the ID group (median 165 vs 240 m, p=0.035; figure 6) but statistical significance was lost after adjusting for differences in FEV1 (p=0.081). Differences in SGRQ scores, HAD scores, and ESS between ID and IR groups, did not reach statistical significance (mean 33.5 vs 30.1, p=0.056; median 13.5 vs 11, p=0.133 and median 8 vs 5, p=0.279, respectively).

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus