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A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus

Box plots showing distribution of (A) erythropoietin (EPO) and (B) haemoglobin (Hb) concentration, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. EPO was significantly higher in the iron-deficient (ID) group (median 23.9 vs 13.5 mIU/mL, p=0.001) but Hb did not differ (mean 13.4 vs 13.8 g/dL; p=0.260).
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BMJOPEN2015007911F5: Box plots showing distribution of (A) erythropoietin (EPO) and (B) haemoglobin (Hb) concentration, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. EPO was significantly higher in the iron-deficient (ID) group (median 23.9 vs 13.5 mIU/mL, p=0.001) but Hb did not differ (mean 13.4 vs 13.8 g/dL; p=0.260).

Mentions: Haemoglobin levels were not significantly different in patients with COPD between ID and IR groups despite a significantly higher EPO level in the ID group (figure 5). However, the mean cell volume (MCV) was lower in the ID group (mean 88.8 vs 93.1 fL; p=0.001).


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Box plots showing distribution of (A) erythropoietin (EPO) and (B) haemoglobin (Hb) concentration, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. EPO was significantly higher in the iron-deficient (ID) group (median 23.9 vs 13.5 mIU/mL, p=0.001) but Hb did not differ (mean 13.4 vs 13.8 g/dL; p=0.260).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499677&req=5

BMJOPEN2015007911F5: Box plots showing distribution of (A) erythropoietin (EPO) and (B) haemoglobin (Hb) concentration, by iron status in the chronic obstructive pulmonary disease (COPD) cohort. EPO was significantly higher in the iron-deficient (ID) group (median 23.9 vs 13.5 mIU/mL, p=0.001) but Hb did not differ (mean 13.4 vs 13.8 g/dL; p=0.260).
Mentions: Haemoglobin levels were not significantly different in patients with COPD between ID and IR groups despite a significantly higher EPO level in the ID group (figure 5). However, the mean cell volume (MCV) was lower in the ID group (mean 88.8 vs 93.1 fL; p=0.001).

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus