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A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus

Box plots showing distribution of (A) resting peripheral oxygen saturation (SpO2), (B) resting PO2 on blood gas, (C) mean nocturnal SpO2 and (D) percentage of nocturnal SpO2 recordings <90%, all by iron status, in the chronic obstructive pulmonary disease (COPD) cohort. All measures were significantly worse in the iron-deficient (ID) group (medians 92 vs 95%, p<0.001; 7.97 vs 9.05 kPa, p=0.008; 88.6 vs 91.2%, p=0.015; and 75.3 vs 16.4%; p=0.005, respectively).
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BMJOPEN2015007911F4: Box plots showing distribution of (A) resting peripheral oxygen saturation (SpO2), (B) resting PO2 on blood gas, (C) mean nocturnal SpO2 and (D) percentage of nocturnal SpO2 recordings <90%, all by iron status, in the chronic obstructive pulmonary disease (COPD) cohort. All measures were significantly worse in the iron-deficient (ID) group (medians 92 vs 95%, p<0.001; 7.97 vs 9.05 kPa, p=0.008; 88.6 vs 91.2%, p=0.015; and 75.3 vs 16.4%; p=0.005, respectively).

Mentions: Within the COPD cohort, resting daytime SpO2 was significantly lower in the ID group, as were PO2 on a capillary or arterial blood gas sample and mean nocturnal SpO2. Additionally, the proportion of time spent with nocturnal SpO2 <90% was much higher in the ID group. Figure 4 illustrates these findings. All these relationships persisted after adjustment for FEV1 (p<0.001, p=0.006, p=0.001 and p=0.001, respectively).


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Box plots showing distribution of (A) resting peripheral oxygen saturation (SpO2), (B) resting PO2 on blood gas, (C) mean nocturnal SpO2 and (D) percentage of nocturnal SpO2 recordings <90%, all by iron status, in the chronic obstructive pulmonary disease (COPD) cohort. All measures were significantly worse in the iron-deficient (ID) group (medians 92 vs 95%, p<0.001; 7.97 vs 9.05 kPa, p=0.008; 88.6 vs 91.2%, p=0.015; and 75.3 vs 16.4%; p=0.005, respectively).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499677&req=5

BMJOPEN2015007911F4: Box plots showing distribution of (A) resting peripheral oxygen saturation (SpO2), (B) resting PO2 on blood gas, (C) mean nocturnal SpO2 and (D) percentage of nocturnal SpO2 recordings <90%, all by iron status, in the chronic obstructive pulmonary disease (COPD) cohort. All measures were significantly worse in the iron-deficient (ID) group (medians 92 vs 95%, p<0.001; 7.97 vs 9.05 kPa, p=0.008; 88.6 vs 91.2%, p=0.015; and 75.3 vs 16.4%; p=0.005, respectively).
Mentions: Within the COPD cohort, resting daytime SpO2 was significantly lower in the ID group, as were PO2 on a capillary or arterial blood gas sample and mean nocturnal SpO2. Additionally, the proportion of time spent with nocturnal SpO2 <90% was much higher in the ID group. Figure 4 illustrates these findings. All these relationships persisted after adjustment for FEV1 (p<0.001, p=0.006, p=0.001 and p=0.001, respectively).

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus