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A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus

(A) Cumulative frequency plot for C reactive protein (CRP). Data for the chronic obstructive pulmonary disease (COPD) cohort are plotted with a solid line and those for the control cohort with a dashed line; the shaded area indicates the normal range for the assay. (B) Box plot (boxes show IQR and median, whiskers show 10th and 90th centiles, circles are outliers) showing distribution of results for CRP by iron status in the COPD cohort. CRP was significantly higher in the iron-deficient (ID) group (median 10.5 vs 4.0 mg/L, p<0.001).
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BMJOPEN2015007911F2: (A) Cumulative frequency plot for C reactive protein (CRP). Data for the chronic obstructive pulmonary disease (COPD) cohort are plotted with a solid line and those for the control cohort with a dashed line; the shaded area indicates the normal range for the assay. (B) Box plot (boxes show IQR and median, whiskers show 10th and 90th centiles, circles are outliers) showing distribution of results for CRP by iron status in the COPD cohort. CRP was significantly higher in the iron-deficient (ID) group (median 10.5 vs 4.0 mg/L, p<0.001).

Mentions: In the COPD cohort, 37 patients (33%) had a CRP greater than 8 mg/L, the upper limit of normal for the assay used (figure 2A). In contrast, there was none in the control cohort (p<0.001, χ2). For the patients with COPD, CRP was significantly higher in the ID than in the IR group (median 10.5 vs 4.0, p<0.001; figure 2B), a relationship that persisted after adjustment for differences in FEV1 (p=0.028). The ID group had a higher self-reported rate of exacerbations in the year prior to enrolment (median 3 (IQR 2–6) vs 2 (IQR 1–4); p=0.024). Again, this relationship persisted after adjustment for differences in FEV1 (p=0.045).


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA - BMJ Open (2015)

(A) Cumulative frequency plot for C reactive protein (CRP). Data for the chronic obstructive pulmonary disease (COPD) cohort are plotted with a solid line and those for the control cohort with a dashed line; the shaded area indicates the normal range for the assay. (B) Box plot (boxes show IQR and median, whiskers show 10th and 90th centiles, circles are outliers) showing distribution of results for CRP by iron status in the COPD cohort. CRP was significantly higher in the iron-deficient (ID) group (median 10.5 vs 4.0 mg/L, p<0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499677&req=5

BMJOPEN2015007911F2: (A) Cumulative frequency plot for C reactive protein (CRP). Data for the chronic obstructive pulmonary disease (COPD) cohort are plotted with a solid line and those for the control cohort with a dashed line; the shaded area indicates the normal range for the assay. (B) Box plot (boxes show IQR and median, whiskers show 10th and 90th centiles, circles are outliers) showing distribution of results for CRP by iron status in the COPD cohort. CRP was significantly higher in the iron-deficient (ID) group (median 10.5 vs 4.0 mg/L, p<0.001).
Mentions: In the COPD cohort, 37 patients (33%) had a CRP greater than 8 mg/L, the upper limit of normal for the assay used (figure 2A). In contrast, there was none in the control cohort (p<0.001, χ2). For the patients with COPD, CRP was significantly higher in the ID than in the IR group (median 10.5 vs 4.0, p<0.001; figure 2B), a relationship that persisted after adjustment for differences in FEV1 (p=0.028). The ID group had a higher self-reported rate of exacerbations in the year prior to enrolment (median 3 (IQR 2–6) vs 2 (IQR 1–4); p=0.024). Again, this relationship persisted after adjustment for differences in FEV1 (p=0.045).

Bottom Line: Iron deficiency, with or without anaemia, is associated with other chronic conditions, such as congestive heart failure, where it predicts a worse outcome.Patients with iron deficiency had more self-reported exacerbations and a trend towards worse exercise tolerance.Iron deficiency associates with hypoxaemia, an excess of exacerbations and, possibly, worse exercise tolerance, all markers of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Oxford Centre for Respiratory Medicine and the Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

No MeSH data available.


Related in: MedlinePlus