Limits...
Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis.

Park JH, Park GM, Kim JK - Korean J. Physiol. Pharmacol. (2015)

Bottom Line: Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants.In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis.Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Catholic University of Daegu, Gyeongsan 712-702, Korea.

ABSTRACT
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

No MeSH data available.


Related in: MedlinePlus

Effect of zerumbone on microvessel outgrowth arising from rat aortic rings. Aortic rings isolated from SD rats were embedded in matrigel in 48-well plates, and then fed with medium containing zerumbone for 7 days. Photographs are representative of three independent experiments.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4499645&req=5

Figure 3: Effect of zerumbone on microvessel outgrowth arising from rat aortic rings. Aortic rings isolated from SD rats were embedded in matrigel in 48-well plates, and then fed with medium containing zerumbone for 7 days. Photographs are representative of three independent experiments.

Mentions: An ex vivo rat thoracic aorta ring assay was employed to evaluate the anti-angiogenic activity of zerumbone. The rat thoracic aorta ring model mimics the in vivo condition compared with the HUVECs tuber formation model in view of the multiple steps (sprouting, proliferation, migration and differentiation) involved in angiogenesis [22]. As predicted, zerumbone appeared to reduce microvessel outgrowth in a concentration-dependent manner, with angiogenesis being nearly abrogated at 100 and 200 µM (Fig. 3).


Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis.

Park JH, Park GM, Kim JK - Korean J. Physiol. Pharmacol. (2015)

Effect of zerumbone on microvessel outgrowth arising from rat aortic rings. Aortic rings isolated from SD rats were embedded in matrigel in 48-well plates, and then fed with medium containing zerumbone for 7 days. Photographs are representative of three independent experiments.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499645&req=5

Figure 3: Effect of zerumbone on microvessel outgrowth arising from rat aortic rings. Aortic rings isolated from SD rats were embedded in matrigel in 48-well plates, and then fed with medium containing zerumbone for 7 days. Photographs are representative of three independent experiments.
Mentions: An ex vivo rat thoracic aorta ring assay was employed to evaluate the anti-angiogenic activity of zerumbone. The rat thoracic aorta ring model mimics the in vivo condition compared with the HUVECs tuber formation model in view of the multiple steps (sprouting, proliferation, migration and differentiation) involved in angiogenesis [22]. As predicted, zerumbone appeared to reduce microvessel outgrowth in a concentration-dependent manner, with angiogenesis being nearly abrogated at 100 and 200 µM (Fig. 3).

Bottom Line: Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants.In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis.Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Catholic University of Daegu, Gyeongsan 712-702, Korea.

ABSTRACT
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

No MeSH data available.


Related in: MedlinePlus