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Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis.

Park JH, Park GM, Kim JK - Korean J. Physiol. Pharmacol. (2015)

Bottom Line: Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants.In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis.Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Catholic University of Daegu, Gyeongsan 712-702, Korea.

ABSTRACT
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

No MeSH data available.


Related in: MedlinePlus

Structure of Zerumbone.
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Figure 1: Structure of Zerumbone.

Mentions: Zerumbone ((2E, 6E, 10E)-2, 6, 9, 9-tetramethylcycloundeca-2, 6, 10-trien-1-one, Fig. 1) is a phytochemical that was first isolated from the essential volatile oil of rhizomes of Zingiber zerumbet [13]. Its potentially broad use in the treatment of cancers, leukemia and virus infection has been indicated [141516]. In addition, zerumbone has a variety of pharmacological effects, which include anti-oxidant, anti-inflammatory and anti-bacterial activity [1718]. More recently, zerumbone was demonstrated to inhibit angiogenesis by blocking nuclear factor-κB in pancreatic and gastric cancer [1920]. But, the detail mechanisms of its anti-angiogenic effect on human endothelial cells remain unclear.


Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis.

Park JH, Park GM, Kim JK - Korean J. Physiol. Pharmacol. (2015)

Structure of Zerumbone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499645&req=5

Figure 1: Structure of Zerumbone.
Mentions: Zerumbone ((2E, 6E, 10E)-2, 6, 9, 9-tetramethylcycloundeca-2, 6, 10-trien-1-one, Fig. 1) is a phytochemical that was first isolated from the essential volatile oil of rhizomes of Zingiber zerumbet [13]. Its potentially broad use in the treatment of cancers, leukemia and virus infection has been indicated [141516]. In addition, zerumbone has a variety of pharmacological effects, which include anti-oxidant, anti-inflammatory and anti-bacterial activity [1718]. More recently, zerumbone was demonstrated to inhibit angiogenesis by blocking nuclear factor-κB in pancreatic and gastric cancer [1920]. But, the detail mechanisms of its anti-angiogenic effect on human endothelial cells remain unclear.

Bottom Line: Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants.In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis.Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Science, Catholic University of Daegu, Gyeongsan 712-702, Korea.

ABSTRACT
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.

No MeSH data available.


Related in: MedlinePlus