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CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors.

Brook OR, Thornton E, Mendiratta-Lala M, Mahadevan A, Raptopoulos V, Brook A, Najarian R, Sheiman R, Siewert B - Gastroenterol Res Pract (2015)

Bottom Line: Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) metastases, and 7/7 (100%) of CCCs.Conclusion.Prominent halo of delayed enhancement of the adjacent liver is frequent finding.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

ABSTRACT
Purpose. To study radiological response to stereotactic radiotherapy for focal liver tumors. Materials and Methods. In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive patients who underwent stereotactic radiotherapy for liver tumors between 01/2006 and 01/2010 were retrospectively reviewed. Two independent reviewers evaluated lesion volume and enhancement pattern of the lesion and of juxtaposed liver parenchyma. Results. 36 subjects with hepatocellular carcinoma (HCC), 25 with liver metastases, and seven with cholangiocarcinoma (CCC) were included in study. Mean follow-up time was 5.6 ± 7.1 months for HCC, 6.4 ± 5.1 months for metastases, and 10.1 ± 4.8 months for the CCC. Complete response was seen in 4/36 (11.1%) HCCs and 1/25 (4%) metastases. Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) metastases, and 7/7 (100%) of CCCs. Partial response followed by local recurrence (>20% increase in long diameter from nadir) occurred in 2/36 (6%) HCCs and 4/25 (17%) metastases. Liver parenchyma adjacent to the lesion demonstrated a prominent halo of delayed enhancement in 27/36 (78%) of HCCs, 19/21 (91%) of metastases, and 7/7 (100%) of CCCs. Conclusion. Sustainable radiological partial response to stereotactic radiotherapy is most frequent outcome seen in liver lesions. Prominent halo of delayed enhancement of the adjacent liver is frequent finding.

No MeSH data available.


Related in: MedlinePlus

Three types of responses of surrounding liver parenchyma to stereotactic radiotherapy treatment of hepatocellular carcinoma lesions, as seen on delayed imaging: hyperdense halo (a), the most frequent response, followed by isodense liver parenchyma (b), and hypodense halo (c). Arrows are pointing to the treated lesion and arrowheads to the response of the surrounding liver.
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fig4: Three types of responses of surrounding liver parenchyma to stereotactic radiotherapy treatment of hepatocellular carcinoma lesions, as seen on delayed imaging: hyperdense halo (a), the most frequent response, followed by isodense liver parenchyma (b), and hypodense halo (c). Arrows are pointing to the treated lesion and arrowheads to the response of the surrounding liver.

Mentions: During follow-up the appearance of the liver parenchyma surrounding the treated lesion changed from isodense to relatively higher attenuation in 27/36 lesions (75%). In these cases, high attenuation of the adjacent liver parenchyma was seen on all postcontrast phases and persisted on all follow-up studies. The liver appeared isodense to the rest of the liver in 8/36 lesions (22%) and hypodense in 1/36 lesions (3%), as seen in Figure 4. The appearance of the liver parenchyma after treatment was significantly different from before treatment (p < 0.001).


CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors.

Brook OR, Thornton E, Mendiratta-Lala M, Mahadevan A, Raptopoulos V, Brook A, Najarian R, Sheiman R, Siewert B - Gastroenterol Res Pract (2015)

Three types of responses of surrounding liver parenchyma to stereotactic radiotherapy treatment of hepatocellular carcinoma lesions, as seen on delayed imaging: hyperdense halo (a), the most frequent response, followed by isodense liver parenchyma (b), and hypodense halo (c). Arrows are pointing to the treated lesion and arrowheads to the response of the surrounding liver.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4499630&req=5

fig4: Three types of responses of surrounding liver parenchyma to stereotactic radiotherapy treatment of hepatocellular carcinoma lesions, as seen on delayed imaging: hyperdense halo (a), the most frequent response, followed by isodense liver parenchyma (b), and hypodense halo (c). Arrows are pointing to the treated lesion and arrowheads to the response of the surrounding liver.
Mentions: During follow-up the appearance of the liver parenchyma surrounding the treated lesion changed from isodense to relatively higher attenuation in 27/36 lesions (75%). In these cases, high attenuation of the adjacent liver parenchyma was seen on all postcontrast phases and persisted on all follow-up studies. The liver appeared isodense to the rest of the liver in 8/36 lesions (22%) and hypodense in 1/36 lesions (3%), as seen in Figure 4. The appearance of the liver parenchyma after treatment was significantly different from before treatment (p < 0.001).

Bottom Line: Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) metastases, and 7/7 (100%) of CCCs.Conclusion.Prominent halo of delayed enhancement of the adjacent liver is frequent finding.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

ABSTRACT
Purpose. To study radiological response to stereotactic radiotherapy for focal liver tumors. Materials and Methods. In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive patients who underwent stereotactic radiotherapy for liver tumors between 01/2006 and 01/2010 were retrospectively reviewed. Two independent reviewers evaluated lesion volume and enhancement pattern of the lesion and of juxtaposed liver parenchyma. Results. 36 subjects with hepatocellular carcinoma (HCC), 25 with liver metastases, and seven with cholangiocarcinoma (CCC) were included in study. Mean follow-up time was 5.6 ± 7.1 months for HCC, 6.4 ± 5.1 months for metastases, and 10.1 ± 4.8 months for the CCC. Complete response was seen in 4/36 (11.1%) HCCs and 1/25 (4%) metastases. Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) metastases, and 7/7 (100%) of CCCs. Partial response followed by local recurrence (>20% increase in long diameter from nadir) occurred in 2/36 (6%) HCCs and 4/25 (17%) metastases. Liver parenchyma adjacent to the lesion demonstrated a prominent halo of delayed enhancement in 27/36 (78%) of HCCs, 19/21 (91%) of metastases, and 7/7 (100%) of CCCs. Conclusion. Sustainable radiological partial response to stereotactic radiotherapy is most frequent outcome seen in liver lesions. Prominent halo of delayed enhancement of the adjacent liver is frequent finding.

No MeSH data available.


Related in: MedlinePlus