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Neurilemmoma of Retromolar Region in the Oral Cavity.

Rathore AS, Srivastava D, Narwal N, Shetty DC - Case Rep Dent (2015)

Bottom Line: Neurilemmoma also known as schwannoma is benign nerve sheath tumor rarely occurring in the oral cavity.It presents as encapsulated, slow growing, solitary, smooth-surfaced, usually asymptomatic tumor.We report a case of 70-year-old male with well-defined mass on left retromolar region which was painless and slow growing.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, I.T.S. Dental College, Murad Nagar, Ghaziabad, Uttar Pradesh 201206, India.

ABSTRACT
Neurilemmoma also known as schwannoma is benign nerve sheath tumor rarely occurring in the oral cavity. Only 1% of all extracranial schwannomas show that intraoral occurrence with tongue is the commonest site and retromolar region is the least common site. It presents as encapsulated, slow growing, solitary, smooth-surfaced, usually asymptomatic tumor. We report a case of 70-year-old male with well-defined mass on left retromolar region which was painless and slow growing. Diagnosis is made by histological examination and immunohistochemistry analysis to confirm the neural tissue origin of the lesion. The treatment is complete surgical excision of the lesion without recurrence.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph showing spindle or oval cells in loosely textured matrix (Antoni B areas) (H&E 40x).
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Related In: Results  -  Collection


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fig7: Photomicrograph showing spindle or oval cells in loosely textured matrix (Antoni B areas) (H&E 40x).

Mentions: Microscopically the tissue showed highly cellular areas enclosed within a fibrous capsule. The tumor was composed of fascicular pattern predominantly with nuclear palisading appearing like Antoni A areas (Figure 5) with intermittent homogeneous eosinophilic areas resembling Verocay bodies (Figure 6). Cellular components were spindle, round to ovoid shape cells with plump and hyperchromatic nuclei and focal areas of pleomorphic cells were also seen. Some ovoid cells exhibited blunt ended nuclei. Focal areas of Antoni B type hypocellular areas were composed of spindle and oval cells arranged haphazardly in loosely textured matrix which also showed few inflammatory cells and delicate collagen fibres (Figure 7). Few thick walled blood vessels and adipocytes were seen. Nerve bundles were also appreciated in the fibrous capsule. Vimentin, smooth muscle actin, and S-100 protein (Figure 8) were performed where S-100 protein and vimentin were found to be strongly reactive in the spindle cells while smooth muscle actin was negative. Histopathological diagnosis of neurilemmoma was given.


Neurilemmoma of Retromolar Region in the Oral Cavity.

Rathore AS, Srivastava D, Narwal N, Shetty DC - Case Rep Dent (2015)

Photomicrograph showing spindle or oval cells in loosely textured matrix (Antoni B areas) (H&E 40x).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4499617&req=5

fig7: Photomicrograph showing spindle or oval cells in loosely textured matrix (Antoni B areas) (H&E 40x).
Mentions: Microscopically the tissue showed highly cellular areas enclosed within a fibrous capsule. The tumor was composed of fascicular pattern predominantly with nuclear palisading appearing like Antoni A areas (Figure 5) with intermittent homogeneous eosinophilic areas resembling Verocay bodies (Figure 6). Cellular components were spindle, round to ovoid shape cells with plump and hyperchromatic nuclei and focal areas of pleomorphic cells were also seen. Some ovoid cells exhibited blunt ended nuclei. Focal areas of Antoni B type hypocellular areas were composed of spindle and oval cells arranged haphazardly in loosely textured matrix which also showed few inflammatory cells and delicate collagen fibres (Figure 7). Few thick walled blood vessels and adipocytes were seen. Nerve bundles were also appreciated in the fibrous capsule. Vimentin, smooth muscle actin, and S-100 protein (Figure 8) were performed where S-100 protein and vimentin were found to be strongly reactive in the spindle cells while smooth muscle actin was negative. Histopathological diagnosis of neurilemmoma was given.

Bottom Line: Neurilemmoma also known as schwannoma is benign nerve sheath tumor rarely occurring in the oral cavity.It presents as encapsulated, slow growing, solitary, smooth-surfaced, usually asymptomatic tumor.We report a case of 70-year-old male with well-defined mass on left retromolar region which was painless and slow growing.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, I.T.S. Dental College, Murad Nagar, Ghaziabad, Uttar Pradesh 201206, India.

ABSTRACT
Neurilemmoma also known as schwannoma is benign nerve sheath tumor rarely occurring in the oral cavity. Only 1% of all extracranial schwannomas show that intraoral occurrence with tongue is the commonest site and retromolar region is the least common site. It presents as encapsulated, slow growing, solitary, smooth-surfaced, usually asymptomatic tumor. We report a case of 70-year-old male with well-defined mass on left retromolar region which was painless and slow growing. Diagnosis is made by histological examination and immunohistochemistry analysis to confirm the neural tissue origin of the lesion. The treatment is complete surgical excision of the lesion without recurrence.

No MeSH data available.


Related in: MedlinePlus