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Primary Squamous Cell Carcinoma of Thyroid: A Rare Entity.

Chavan RN, Chikkala B, Biswas C, Biswas S, Sarkar DK - Case Rep Pathol (2015)

Bottom Line: Primary squamous cell carcinoma (PSCC) of thyroid is an extremely rare malignancy of thyroid.After extensive investigations no possible primary focus of squamous cell carcinoma was found elsewhere, so diagnosis of primary squamous cell carcinoma of thyroid was made.Patient underwent chemoradiation but still patient succumbed to death within a year.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, IPGMER, Kolkata 700025, India ; DY Patil University School of Medicine, Navi Mumbai, India.

ABSTRACT
Primary squamous cell carcinoma (PSCC) of thyroid is an extremely rare malignancy of thyroid. Herewith, we describe a case report of female patient who presented with neck swelling; FNAC misdiagnosed it as papillary carcinoma of thyroid but, after resection, biopsy revealed it to be a case of squamous cell carcinoma of thyroid. After extensive investigations no possible primary focus of squamous cell carcinoma was found elsewhere, so diagnosis of primary squamous cell carcinoma of thyroid was made. Patient underwent chemoradiation but still patient succumbed to death within a year.

No MeSH data available.


Related in: MedlinePlus

H/E × 100 section from the thyroid gland showing infiltrative squamous cell carcinoma of thyroid.
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fig2: H/E × 100 section from the thyroid gland showing infiltrative squamous cell carcinoma of thyroid.

Mentions: A 49-year-old lady presented with a mass in the left lower neck for 1 year. She had history of rapid growth of the same lesion over the last two weeks. There was no history of hyper/hypofunction of the thyroid. She complained of recent onset of pain associated with the swelling radiating to the back of the left ear, along with dysphagia. She had no addiction to tobacco or alcohol. On examination, the left lobe of the thyroid gland was enlarged (3 cm × 3 cm) with a palpable level IV cervical lymph node. Fine needle aspiration from the mass revealed papillary carcinoma of thyroid. Computed tomography (CT) scan of the neck showed a soft tissue density mass arising from the inferior aspect of left lobe of thyroid, extending up to the thoracic inlet and to the right side, with compression of oesophagus. Laryngoscopy was normal. Patient was planned for total thyroidectomy. Intraoperatively, the mass was adherent to soft tissue. A thyroidectomy and left sided radical neck dissection were done. Postoperatively, histopathological examination revealed a moderately to poorly differentiated squamous cell carcinoma of the thyroid with lymph node metastasis and invading adjacent soft tissue (Figures 1 and 2). Immunohistochemistry helped in making diagnosis. Tumor showed positivity for CK5/6, 7, 19 and p 63 as well. Tumor was negative for TTF- (thyroid transcription factor-) 1, thyroglobulin, calcitonin, p16, and CK20. Postoperatively, diligent search was made, if there was possible primary malignant lesion of squamous cell origin, causing metastasis to thyroid. Patient underwent thorough endoscopic studies, examination under anesthesia (along with tonsillectomy and directed biopsies), and imaging studies (CT and MRI scan of head and neck, CT scan of trunk, and PET-CT), but no possible origin for PSCC of thyroid could be identified. Patient was referred for chemotherapy and radiotherapy, still patient died within a year.


Primary Squamous Cell Carcinoma of Thyroid: A Rare Entity.

Chavan RN, Chikkala B, Biswas C, Biswas S, Sarkar DK - Case Rep Pathol (2015)

H/E × 100 section from the thyroid gland showing infiltrative squamous cell carcinoma of thyroid.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4499613&req=5

fig2: H/E × 100 section from the thyroid gland showing infiltrative squamous cell carcinoma of thyroid.
Mentions: A 49-year-old lady presented with a mass in the left lower neck for 1 year. She had history of rapid growth of the same lesion over the last two weeks. There was no history of hyper/hypofunction of the thyroid. She complained of recent onset of pain associated with the swelling radiating to the back of the left ear, along with dysphagia. She had no addiction to tobacco or alcohol. On examination, the left lobe of the thyroid gland was enlarged (3 cm × 3 cm) with a palpable level IV cervical lymph node. Fine needle aspiration from the mass revealed papillary carcinoma of thyroid. Computed tomography (CT) scan of the neck showed a soft tissue density mass arising from the inferior aspect of left lobe of thyroid, extending up to the thoracic inlet and to the right side, with compression of oesophagus. Laryngoscopy was normal. Patient was planned for total thyroidectomy. Intraoperatively, the mass was adherent to soft tissue. A thyroidectomy and left sided radical neck dissection were done. Postoperatively, histopathological examination revealed a moderately to poorly differentiated squamous cell carcinoma of the thyroid with lymph node metastasis and invading adjacent soft tissue (Figures 1 and 2). Immunohistochemistry helped in making diagnosis. Tumor showed positivity for CK5/6, 7, 19 and p 63 as well. Tumor was negative for TTF- (thyroid transcription factor-) 1, thyroglobulin, calcitonin, p16, and CK20. Postoperatively, diligent search was made, if there was possible primary malignant lesion of squamous cell origin, causing metastasis to thyroid. Patient underwent thorough endoscopic studies, examination under anesthesia (along with tonsillectomy and directed biopsies), and imaging studies (CT and MRI scan of head and neck, CT scan of trunk, and PET-CT), but no possible origin for PSCC of thyroid could be identified. Patient was referred for chemotherapy and radiotherapy, still patient died within a year.

Bottom Line: Primary squamous cell carcinoma (PSCC) of thyroid is an extremely rare malignancy of thyroid.After extensive investigations no possible primary focus of squamous cell carcinoma was found elsewhere, so diagnosis of primary squamous cell carcinoma of thyroid was made.Patient underwent chemoradiation but still patient succumbed to death within a year.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, IPGMER, Kolkata 700025, India ; DY Patil University School of Medicine, Navi Mumbai, India.

ABSTRACT
Primary squamous cell carcinoma (PSCC) of thyroid is an extremely rare malignancy of thyroid. Herewith, we describe a case report of female patient who presented with neck swelling; FNAC misdiagnosed it as papillary carcinoma of thyroid but, after resection, biopsy revealed it to be a case of squamous cell carcinoma of thyroid. After extensive investigations no possible primary focus of squamous cell carcinoma was found elsewhere, so diagnosis of primary squamous cell carcinoma of thyroid was made. Patient underwent chemoradiation but still patient succumbed to death within a year.

No MeSH data available.


Related in: MedlinePlus