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Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis.

Beiske GA, Holmøy T, Beiske AG, Johannessen SI, Johannessen Landmark C - Mult Scler Int (2015)

Bottom Line: Age, gender, and EDSS scores did not differ significantly between those using and not using AED/amitriptyline.Conclusion.The high prevalence of polypharmacy and use of CNS-active drugs calls for awareness of especially pharmacodynamic interactions and possible excessive adverse effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences and Health, Programme for Pharmacy, Oslo and Akershus University College, 0167 Oslo, Norway.

ABSTRACT
Objective. Patients with multiple sclerosis (MS) are often suffering from neuropathic pain. Antiepileptic drugs (AEDs) and tricyclic antidepressants (TCAs) are commonly used and are susceptible to be involved in drug interactions. The aim of this retrospective study was to investigate the prevalence of use of antiepileptic and antidepressive drugs in MS patients and to discuss the theoretical potential for interactions. Methods. Review of the medical records from all patients treated at a dedicated MS rehabilitation centre in Norway between 2009 and 2012. Results. In total 1090 patients attended a rehabilitation stay during the study period. Of these, 342 (31%; 249 females) with mean age of 53 (±10) years and EDSS 4.8 (±1.7) used at least one AED (gabapentin 12.7%, pregabalin 7.7%, clonazepam 7.8%, and carbamazepine 2.6%) or amitriptyline (9.7%). Polypharmacy was widespread (mean 5.4 drugs) with 60% using additional CNS-active drugs with a propensity to be involved in interactions. Age, gender, and EDSS scores did not differ significantly between those using and not using AED/amitriptyline. Conclusion. One-third of MS patients attending a rehabilitation stay receive AED/amitriptyline treatment. The high prevalence of polypharmacy and use of CNS-active drugs calls for awareness of especially pharmacodynamic interactions and possible excessive adverse effects.

No MeSH data available.


Related in: MedlinePlus

Expanded Disability Status Scale score distribution of the MS Rehabilitation Centre population (N = 585) divided into two groups based on the use of antiepileptic drugs (AED) and/or amitriptyline (TCA).
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Related In: Results  -  Collection


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fig2: Expanded Disability Status Scale score distribution of the MS Rehabilitation Centre population (N = 585) divided into two groups based on the use of antiepileptic drugs (AED) and/or amitriptyline (TCA).

Mentions: Figure 2 shows the wide distribution of functional levels in the MS Rehabilitation Centre population divided into two groups based on the use of AED/amitriptyline.


Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis.

Beiske GA, Holmøy T, Beiske AG, Johannessen SI, Johannessen Landmark C - Mult Scler Int (2015)

Expanded Disability Status Scale score distribution of the MS Rehabilitation Centre population (N = 585) divided into two groups based on the use of antiepileptic drugs (AED) and/or amitriptyline (TCA).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4499608&req=5

fig2: Expanded Disability Status Scale score distribution of the MS Rehabilitation Centre population (N = 585) divided into two groups based on the use of antiepileptic drugs (AED) and/or amitriptyline (TCA).
Mentions: Figure 2 shows the wide distribution of functional levels in the MS Rehabilitation Centre population divided into two groups based on the use of AED/amitriptyline.

Bottom Line: Age, gender, and EDSS scores did not differ significantly between those using and not using AED/amitriptyline.Conclusion.The high prevalence of polypharmacy and use of CNS-active drugs calls for awareness of especially pharmacodynamic interactions and possible excessive adverse effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences and Health, Programme for Pharmacy, Oslo and Akershus University College, 0167 Oslo, Norway.

ABSTRACT
Objective. Patients with multiple sclerosis (MS) are often suffering from neuropathic pain. Antiepileptic drugs (AEDs) and tricyclic antidepressants (TCAs) are commonly used and are susceptible to be involved in drug interactions. The aim of this retrospective study was to investigate the prevalence of use of antiepileptic and antidepressive drugs in MS patients and to discuss the theoretical potential for interactions. Methods. Review of the medical records from all patients treated at a dedicated MS rehabilitation centre in Norway between 2009 and 2012. Results. In total 1090 patients attended a rehabilitation stay during the study period. Of these, 342 (31%; 249 females) with mean age of 53 (±10) years and EDSS 4.8 (±1.7) used at least one AED (gabapentin 12.7%, pregabalin 7.7%, clonazepam 7.8%, and carbamazepine 2.6%) or amitriptyline (9.7%). Polypharmacy was widespread (mean 5.4 drugs) with 60% using additional CNS-active drugs with a propensity to be involved in interactions. Age, gender, and EDSS scores did not differ significantly between those using and not using AED/amitriptyline. Conclusion. One-third of MS patients attending a rehabilitation stay receive AED/amitriptyline treatment. The high prevalence of polypharmacy and use of CNS-active drugs calls for awareness of especially pharmacodynamic interactions and possible excessive adverse effects.

No MeSH data available.


Related in: MedlinePlus