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Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy.

Park YH, Choi JW, Jung SO, Cho MJ, Kang DH, Chung CU, Park DI, Moon JY, Park HS, Jung SS, Kim JO, Kim SY, Lee JE - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium.However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported.We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

ABSTRACT
Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium. Typically, pleural fluid cytology or closed pleural biopsy, surgical intervention (video thoracoscopic biopsy or open thoracotomy) is conducted to obtain pleural tissue specimens. However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported. We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

No MeSH data available.


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(A-D) Initial bronchoscopic biopsy findings of papillary clusters of epithelioid cells, and positive staining with anti-calretinin antibody, cytokeratin 5/6, and Wilms tumor 1 stain in most of the neoplastic cells. (E-H) Pleural biopsy findings of neoplastic cells positive for anti-calretinin antibody, and cytokeratin 5/6, and definitive Wilms tumor 1. (I-L) Follow-up bronchoscopic biopsy findings of neoplastic cells positive for anti-calretinin antibody, and negative for p63, Wilms tumor 1 stain.
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Figure 3: (A-D) Initial bronchoscopic biopsy findings of papillary clusters of epithelioid cells, and positive staining with anti-calretinin antibody, cytokeratin 5/6, and Wilms tumor 1 stain in most of the neoplastic cells. (E-H) Pleural biopsy findings of neoplastic cells positive for anti-calretinin antibody, and cytokeratin 5/6, and definitive Wilms tumor 1. (I-L) Follow-up bronchoscopic biopsy findings of neoplastic cells positive for anti-calretinin antibody, and negative for p63, Wilms tumor 1 stain.

Mentions: Bronchoscopic biopsy and immunohistochemical stain revealed malignant mesothelioma (Figure 3). And we reviewed slides of pleural biopsy performed at the other hospital, it was also revealed as malignant mesothelioma. On immunohistochemical stain of bronchoscopic biopsy specimen, Wilms tumor 1 (WT-1), calretinin, cytokeratin 5/6 (CK5/6), p63 were all positive and napsin-A, thyroid transcription factor 1 (TTF-1) were negative. Those of pleural biopsy specimen, calretinin, D2-40, CK5/6, and p63 were positive, and napsin-A and TTF-1 were negative (Figure 3).


Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy.

Park YH, Choi JW, Jung SO, Cho MJ, Kang DH, Chung CU, Park DI, Moon JY, Park HS, Jung SS, Kim JO, Kim SY, Lee JE - Tuberc Respir Dis (Seoul) (2015)

(A-D) Initial bronchoscopic biopsy findings of papillary clusters of epithelioid cells, and positive staining with anti-calretinin antibody, cytokeratin 5/6, and Wilms tumor 1 stain in most of the neoplastic cells. (E-H) Pleural biopsy findings of neoplastic cells positive for anti-calretinin antibody, and cytokeratin 5/6, and definitive Wilms tumor 1. (I-L) Follow-up bronchoscopic biopsy findings of neoplastic cells positive for anti-calretinin antibody, and negative for p63, Wilms tumor 1 stain.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499604&req=5

Figure 3: (A-D) Initial bronchoscopic biopsy findings of papillary clusters of epithelioid cells, and positive staining with anti-calretinin antibody, cytokeratin 5/6, and Wilms tumor 1 stain in most of the neoplastic cells. (E-H) Pleural biopsy findings of neoplastic cells positive for anti-calretinin antibody, and cytokeratin 5/6, and definitive Wilms tumor 1. (I-L) Follow-up bronchoscopic biopsy findings of neoplastic cells positive for anti-calretinin antibody, and negative for p63, Wilms tumor 1 stain.
Mentions: Bronchoscopic biopsy and immunohistochemical stain revealed malignant mesothelioma (Figure 3). And we reviewed slides of pleural biopsy performed at the other hospital, it was also revealed as malignant mesothelioma. On immunohistochemical stain of bronchoscopic biopsy specimen, Wilms tumor 1 (WT-1), calretinin, cytokeratin 5/6 (CK5/6), p63 were all positive and napsin-A, thyroid transcription factor 1 (TTF-1) were negative. Those of pleural biopsy specimen, calretinin, D2-40, CK5/6, and p63 were positive, and napsin-A and TTF-1 were negative (Figure 3).

Bottom Line: Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium.However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported.We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

ABSTRACT
Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium. Typically, pleural fluid cytology or closed pleural biopsy, surgical intervention (video thoracoscopic biopsy or open thoracotomy) is conducted to obtain pleural tissue specimens. However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported. We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

No MeSH data available.


Related in: MedlinePlus