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Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy.

Park YH, Choi JW, Jung SO, Cho MJ, Kang DH, Chung CU, Park DI, Moon JY, Park HS, Jung SS, Kim JO, Kim SY, Lee JE - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium.However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported.We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

ABSTRACT
Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium. Typically, pleural fluid cytology or closed pleural biopsy, surgical intervention (video thoracoscopic biopsy or open thoracotomy) is conducted to obtain pleural tissue specimens. However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported. We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

No MeSH data available.


Related in: MedlinePlus

Positron emission tomography computed tomography showed multiple high uptake lesions (A-C), and bronchoscopic biopsy was obtained from anterobasal segment of right lower lobe (D-F).
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Figure 2: Positron emission tomography computed tomography showed multiple high uptake lesions (A-C), and bronchoscopic biopsy was obtained from anterobasal segment of right lower lobe (D-F).

Mentions: A 77-year-old male visited at a secondary hospital with history of dyspnea. He had a previous history of rectal cancer 20 years ago, complete remission state after Mile's operation and hypertension which was well controlled with losartan. He had been smoked about 55 pack-years. Large pleural effusion of right hemithorax was found on chest radiograph. Thoracentesis and closed pleural biopsy were performed. Pleural fluid analysis yielded exudates (pleural fluid lactate dehydrogenase and total protein were 920 IU/L and 4.6 g/dL, respectively) and pleural fluid culture and culture for acid-fast bacilli were negative. The results of cytology and pleural biopsy were suggestive of malignancy, but primary site was undetermined. PET-CT and chest CT were done, chest CT showed peribronchial soft tissue thickening in right middle lobe (RML), right lower lobe (RLL), that result in severe bronchial narrowing and collapse of RML and RLL, and large amount of pleural effusion. But there is no definite pleural thickening on chest CT. PET-CT showed high glucose uptake in RML, RLL, and pleura (Figures 1, 2).


Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy.

Park YH, Choi JW, Jung SO, Cho MJ, Kang DH, Chung CU, Park DI, Moon JY, Park HS, Jung SS, Kim JO, Kim SY, Lee JE - Tuberc Respir Dis (Seoul) (2015)

Positron emission tomography computed tomography showed multiple high uptake lesions (A-C), and bronchoscopic biopsy was obtained from anterobasal segment of right lower lobe (D-F).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499604&req=5

Figure 2: Positron emission tomography computed tomography showed multiple high uptake lesions (A-C), and bronchoscopic biopsy was obtained from anterobasal segment of right lower lobe (D-F).
Mentions: A 77-year-old male visited at a secondary hospital with history of dyspnea. He had a previous history of rectal cancer 20 years ago, complete remission state after Mile's operation and hypertension which was well controlled with losartan. He had been smoked about 55 pack-years. Large pleural effusion of right hemithorax was found on chest radiograph. Thoracentesis and closed pleural biopsy were performed. Pleural fluid analysis yielded exudates (pleural fluid lactate dehydrogenase and total protein were 920 IU/L and 4.6 g/dL, respectively) and pleural fluid culture and culture for acid-fast bacilli were negative. The results of cytology and pleural biopsy were suggestive of malignancy, but primary site was undetermined. PET-CT and chest CT were done, chest CT showed peribronchial soft tissue thickening in right middle lobe (RML), right lower lobe (RLL), that result in severe bronchial narrowing and collapse of RML and RLL, and large amount of pleural effusion. But there is no definite pleural thickening on chest CT. PET-CT showed high glucose uptake in RML, RLL, and pleura (Figures 1, 2).

Bottom Line: Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium.However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported.We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

ABSTRACT
Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium. Typically, pleural fluid cytology or closed pleural biopsy, surgical intervention (video thoracoscopic biopsy or open thoracotomy) is conducted to obtain pleural tissue specimens. However, endobronchial lesions are rarely seen and cases diagnosed from bronchoscopic biopsy are also rarely reported. We reported the case of a 77-year-old male who was diagnosed as malignant mesothelioma on bronchoscopic biopsy from obstructing masses of the endobronchial lesion.

No MeSH data available.


Related in: MedlinePlus