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Lung Disease Caused by Mycobacterium malmoense in an Immunocompetent Patient.

Jeon MK, Yoon JA, Kim J, Yi S, Sung H, Shim TS, Jo KW - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: Mycobacterium malmoense is a very rare cause of lung disease in South Korea.We reported the first case of lung disease caused by M. malmoense in an immunocompetent patient.The patient was successfully treated with a 14-month course of antibiotics.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

ABSTRACT
Mycobacterium malmoense is a very rare cause of lung disease in South Korea. We reported the first case of lung disease caused by M. malmoense in an immunocompetent patient. The patient was successfully treated with a 14-month course of antibiotics.

No MeSH data available.


Related in: MedlinePlus

Chest X-ray (A) and low-dose chest computed tomography (B, C) images taken 12 months after the start of treatment showing reduced number and extent of nodules.
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Figure 3: Chest X-ray (A) and low-dose chest computed tomography (B, C) images taken 12 months after the start of treatment showing reduced number and extent of nodules.

Mentions: Based on these clinical and laboratory data, the patient was given a diagnosis of lung disease caused by M. malmoense, according to the American Thoracic Society (ATS) criteria. M. malmoense was subjected to several rounds of drug susceptibility testing; however, all failed due to contamination. The patient was treated with oral isoniazid, rifampicin, ethambutol, moxifloxacin, and clarithromycin, and his symptoms improved rapidly. Sputum culture conversion was observed after 2 months. Due to the improved clinical course, moxifloxacin was stopped 8 months after initiation. Also, we had to discontinue ethambutol after 10 months due to the onset of optic neuropathy. Treatment was completed 12 months after achieving sputum culture conversion (i.e., treatment lasted 14 months in total). A CXR and CT scan taken 12 months after the start of treatment showed an improvement in the lung lesions (Figure 3). The patient received regular follow-up for 3 months after treatment completion with no relapse of M. malmoense infection.


Lung Disease Caused by Mycobacterium malmoense in an Immunocompetent Patient.

Jeon MK, Yoon JA, Kim J, Yi S, Sung H, Shim TS, Jo KW - Tuberc Respir Dis (Seoul) (2015)

Chest X-ray (A) and low-dose chest computed tomography (B, C) images taken 12 months after the start of treatment showing reduced number and extent of nodules.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499603&req=5

Figure 3: Chest X-ray (A) and low-dose chest computed tomography (B, C) images taken 12 months after the start of treatment showing reduced number and extent of nodules.
Mentions: Based on these clinical and laboratory data, the patient was given a diagnosis of lung disease caused by M. malmoense, according to the American Thoracic Society (ATS) criteria. M. malmoense was subjected to several rounds of drug susceptibility testing; however, all failed due to contamination. The patient was treated with oral isoniazid, rifampicin, ethambutol, moxifloxacin, and clarithromycin, and his symptoms improved rapidly. Sputum culture conversion was observed after 2 months. Due to the improved clinical course, moxifloxacin was stopped 8 months after initiation. Also, we had to discontinue ethambutol after 10 months due to the onset of optic neuropathy. Treatment was completed 12 months after achieving sputum culture conversion (i.e., treatment lasted 14 months in total). A CXR and CT scan taken 12 months after the start of treatment showed an improvement in the lung lesions (Figure 3). The patient received regular follow-up for 3 months after treatment completion with no relapse of M. malmoense infection.

Bottom Line: Mycobacterium malmoense is a very rare cause of lung disease in South Korea.We reported the first case of lung disease caused by M. malmoense in an immunocompetent patient.The patient was successfully treated with a 14-month course of antibiotics.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

ABSTRACT
Mycobacterium malmoense is a very rare cause of lung disease in South Korea. We reported the first case of lung disease caused by M. malmoense in an immunocompetent patient. The patient was successfully treated with a 14-month course of antibiotics.

No MeSH data available.


Related in: MedlinePlus