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Primary Pulmonary Malignant Melanoma: An Unexpected Tumor.

Hwang KB, Hwang KE, Jung JW, Oh SJ, Park MJ, Jeong YH, Choi KH, Jeong ET, Kim HR - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: However, it can also arise in other organs and tissues of the body.The prognosis of this condition is rather poor.Based on previous data, its 5-year survival is at least 10%.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.

ABSTRACT
Malignant melanoma occurs most frequently on the skin. However, it can also arise in other organs and tissues of the body. Primary pulmonary malignant melanoma is a very rare non-epithelial neoplasm accounting for 0.01% of all primary pulmonary tumors. The treatment of choice is surgical resection of the tumor with an oncologically adequate margin as in lobectomy or pneumonectomy. The prognosis of this condition is rather poor. Based on previous data, its 5-year survival is at least 10%. Here, we report a case of an 82-year-old woman whose primary pulmonary melanoma was detected incidentally.

No MeSH data available.


Related in: MedlinePlus

(A) Histopathological examination of the biopsy specimen showing melanoma cells containing melanin granules (H&E stain, ×200). (B) Histopathological features of "nesting" of melanoma cells just beneath the bronchial epithelium (H&E stain, ×400). (C) The melanoma cells are round or spindle shaped with melanin pigmentation and positive for human melanoma black 45 (×200).
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Figure 3: (A) Histopathological examination of the biopsy specimen showing melanoma cells containing melanin granules (H&E stain, ×200). (B) Histopathological features of "nesting" of melanoma cells just beneath the bronchial epithelium (H&E stain, ×400). (C) The melanoma cells are round or spindle shaped with melanin pigmentation and positive for human melanoma black 45 (×200).

Mentions: A solitary mass was detected incidentally in the right lower lobe of the lung in an 82-year-old woman. The results of physical examinations and laboratory tests were within normal limits. Chest computed tomography (CT) showed a heterogeneous enhancing mass lesion of approximately 8 cm in the right lower lobe of the lung (Figure 1). Bronchoscopic examination showed a black-pigmented mass in the posterobasal segment of the right lower lobe, and biopsy was performed (Figure 2). Histopathological examination of the biopsy specimen showed melanoma cells containing melanin granules and "nesting" of melanoma cells just beneath the bronchial epithelium. The melanoma cells were round or spindle shaped, with melanin pigmentation, and these cells were positive for human melanoma black 45 (HMB-45) and vimentin and focally positive for antibodies to S-100 protein (Figure 3). Accordingly, the patient was diagnosed with malignant melanoma.


Primary Pulmonary Malignant Melanoma: An Unexpected Tumor.

Hwang KB, Hwang KE, Jung JW, Oh SJ, Park MJ, Jeong YH, Choi KH, Jeong ET, Kim HR - Tuberc Respir Dis (Seoul) (2015)

(A) Histopathological examination of the biopsy specimen showing melanoma cells containing melanin granules (H&E stain, ×200). (B) Histopathological features of "nesting" of melanoma cells just beneath the bronchial epithelium (H&E stain, ×400). (C) The melanoma cells are round or spindle shaped with melanin pigmentation and positive for human melanoma black 45 (×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499598&req=5

Figure 3: (A) Histopathological examination of the biopsy specimen showing melanoma cells containing melanin granules (H&E stain, ×200). (B) Histopathological features of "nesting" of melanoma cells just beneath the bronchial epithelium (H&E stain, ×400). (C) The melanoma cells are round or spindle shaped with melanin pigmentation and positive for human melanoma black 45 (×200).
Mentions: A solitary mass was detected incidentally in the right lower lobe of the lung in an 82-year-old woman. The results of physical examinations and laboratory tests were within normal limits. Chest computed tomography (CT) showed a heterogeneous enhancing mass lesion of approximately 8 cm in the right lower lobe of the lung (Figure 1). Bronchoscopic examination showed a black-pigmented mass in the posterobasal segment of the right lower lobe, and biopsy was performed (Figure 2). Histopathological examination of the biopsy specimen showed melanoma cells containing melanin granules and "nesting" of melanoma cells just beneath the bronchial epithelium. The melanoma cells were round or spindle shaped, with melanin pigmentation, and these cells were positive for human melanoma black 45 (HMB-45) and vimentin and focally positive for antibodies to S-100 protein (Figure 3). Accordingly, the patient was diagnosed with malignant melanoma.

Bottom Line: However, it can also arise in other organs and tissues of the body.The prognosis of this condition is rather poor.Based on previous data, its 5-year survival is at least 10%.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.

ABSTRACT
Malignant melanoma occurs most frequently on the skin. However, it can also arise in other organs and tissues of the body. Primary pulmonary malignant melanoma is a very rare non-epithelial neoplasm accounting for 0.01% of all primary pulmonary tumors. The treatment of choice is surgical resection of the tumor with an oncologically adequate margin as in lobectomy or pneumonectomy. The prognosis of this condition is rather poor. Based on previous data, its 5-year survival is at least 10%. Here, we report a case of an 82-year-old woman whose primary pulmonary melanoma was detected incidentally.

No MeSH data available.


Related in: MedlinePlus