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Intrathoracic Desmoid Tumor Presenting as Multiple Lung Nodules 13 Years after Previous Resection of Abdominal Wall Desmoid Tumor.

Koo GW, Chung SJ, Kwak JH, Oh CK, Park DW, Kwak HJ, Moon JY, Kim SH, Sohn JW, Yoon HJ, Shin DH, Park SS, Oh YH, Pyo JY, Kim TH - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: Although they are most commonly intraabdominal, very few cases have extra-abdominal locations.The origin of intrathoracic desmoid tumors is predominantly the chest wall with occasional involvement of pleura.True intrathoracic primary desmoid tumors with no involvement of the chest wall or pleura are extremely rare.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT
Desmoid tumors are rare soft tissue tumors considered to have locally infiltrative features without distant metastasis until now. Although they are most commonly intraabdominal, very few cases have extra-abdominal locations. The origin of intrathoracic desmoid tumors is predominantly the chest wall with occasional involvement of pleura. True intrathoracic primary desmoid tumors with no involvement of the chest wall or pleura are extremely rare. We recently experienced a case of true intrathoracic desmoid tumor presenting as multiple lung nodules at 13 years after resection of a previous intraabdominal desmoid tumor.

No MeSH data available.


Related in: MedlinePlus

Histologic findings of biopsy. (A) Lung biopsy revealing spindle-shaped myo- fibroblast proliferation within collagenized and myxoid background (H&E stain, ×200). (B) Spindle cells stained with vimentin (×200). (C) Negative for CD34 (×100). (D) The intra-abdominal mass with the same histology as lung biopsy (H&E stain, ×200).
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Figure 3: Histologic findings of biopsy. (A) Lung biopsy revealing spindle-shaped myo- fibroblast proliferation within collagenized and myxoid background (H&E stain, ×200). (B) Spindle cells stained with vimentin (×200). (C) Negative for CD34 (×100). (D) The intra-abdominal mass with the same histology as lung biopsy (H&E stain, ×200).

Mentions: Fine needle aspiration biopsy (FNAB) targeting the largest nodule in the RLL revealed fibrous tissue. Microscopically, the tumor was composed of bland-looking spindle cells within abundant collagenous tissue with myxoid change (Figure 3A). Immunohistochemically, the spindle cells were positive for vimentin (Figure 3B) and negative for CD34 (Figure 3C) and smooth muscle actin (SMA). This histologic and immunohistochemical findings were compatible with desmoid tumor. In the review of the previous abdominal mass lesion, the histologic and immunohistochemical features of the lung biopsy was same to those of the abdominal mass conducted 16 years ago (Figure 3D). But medical records at that time did not exist and she knew that benign tumor was treated successfully with surgical removal alone. Moreover only a portion of the abdominal wall mass remained and the amount of lung nodule obtained through FNAB was inadequate, it was infeasible to compare both tissues by genetic testing.


Intrathoracic Desmoid Tumor Presenting as Multiple Lung Nodules 13 Years after Previous Resection of Abdominal Wall Desmoid Tumor.

Koo GW, Chung SJ, Kwak JH, Oh CK, Park DW, Kwak HJ, Moon JY, Kim SH, Sohn JW, Yoon HJ, Shin DH, Park SS, Oh YH, Pyo JY, Kim TH - Tuberc Respir Dis (Seoul) (2015)

Histologic findings of biopsy. (A) Lung biopsy revealing spindle-shaped myo- fibroblast proliferation within collagenized and myxoid background (H&E stain, ×200). (B) Spindle cells stained with vimentin (×200). (C) Negative for CD34 (×100). (D) The intra-abdominal mass with the same histology as lung biopsy (H&E stain, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499597&req=5

Figure 3: Histologic findings of biopsy. (A) Lung biopsy revealing spindle-shaped myo- fibroblast proliferation within collagenized and myxoid background (H&E stain, ×200). (B) Spindle cells stained with vimentin (×200). (C) Negative for CD34 (×100). (D) The intra-abdominal mass with the same histology as lung biopsy (H&E stain, ×200).
Mentions: Fine needle aspiration biopsy (FNAB) targeting the largest nodule in the RLL revealed fibrous tissue. Microscopically, the tumor was composed of bland-looking spindle cells within abundant collagenous tissue with myxoid change (Figure 3A). Immunohistochemically, the spindle cells were positive for vimentin (Figure 3B) and negative for CD34 (Figure 3C) and smooth muscle actin (SMA). This histologic and immunohistochemical findings were compatible with desmoid tumor. In the review of the previous abdominal mass lesion, the histologic and immunohistochemical features of the lung biopsy was same to those of the abdominal mass conducted 16 years ago (Figure 3D). But medical records at that time did not exist and she knew that benign tumor was treated successfully with surgical removal alone. Moreover only a portion of the abdominal wall mass remained and the amount of lung nodule obtained through FNAB was inadequate, it was infeasible to compare both tissues by genetic testing.

Bottom Line: Although they are most commonly intraabdominal, very few cases have extra-abdominal locations.The origin of intrathoracic desmoid tumors is predominantly the chest wall with occasional involvement of pleura.True intrathoracic primary desmoid tumors with no involvement of the chest wall or pleura are extremely rare.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT
Desmoid tumors are rare soft tissue tumors considered to have locally infiltrative features without distant metastasis until now. Although they are most commonly intraabdominal, very few cases have extra-abdominal locations. The origin of intrathoracic desmoid tumors is predominantly the chest wall with occasional involvement of pleura. True intrathoracic primary desmoid tumors with no involvement of the chest wall or pleura are extremely rare. We recently experienced a case of true intrathoracic desmoid tumor presenting as multiple lung nodules at 13 years after resection of a previous intraabdominal desmoid tumor.

No MeSH data available.


Related in: MedlinePlus