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Sclerosing Pneumocytoma with a Wax-and-Wane Pattern of Growth: A Case Report on Computed Tomography and Magnetic Resonance Imaging Findings and a Literature Review.

Kim YP, Lee S, Park HS, Park CH, Kim TH - Korean J Radiol (2015)

Bottom Line: Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm.Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman.We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.

ABSTRACT
Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm. Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman. Tumor diameter decreased over a 3-year follow-up period and then increased on serial follow-up computed tomography scans. The mass showed high signal intensity on both T1- and T2-weighted chest magnetic resonance imaging (MRI) and early enhancement with a plateau on dynamic MRI. We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.

No MeSH data available.


Related in: MedlinePlus

Sclerosing pneumocytoma with wax-and-wane growth pattern in 47-year-old woman.A-C. Initial (A) and 1-year (B) and 3-year follow-up (C) contrast-enhanced computed tomography (CT) scans show heterogeneously enhancing mass in left upper lobe. Mass decreases in diameter from 3.1 to 2.1 cm and then marked increase to 3.4 cm on serial CT scans. D. Serial volume graph chart obtained from three-dimensional CT data using automated segmentation technique during follow-up shows wax-and-wane pattern. E, F. Mass shows iso- to higher signal intensity (SI) than that of muscle on T1-weighted magnetic resonance (MR) image (E) and heterogeneously high SI on fat-saturated T2-weighted image (F). G. Dynamic contrast-enhanced MR images and corresponding graph of SI versus time show early enhancement without peak point and subsequent plateau pattern. H. Gross findings show well-demarcated, solid mass with fibrous matrix and areas of hemorrhage. I. Well-demarcated mass with small cystic spaces filled with blood was observed on microscopic examination (hematoxylin and eosin staining, × 12.5).
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Figure 1: Sclerosing pneumocytoma with wax-and-wane growth pattern in 47-year-old woman.A-C. Initial (A) and 1-year (B) and 3-year follow-up (C) contrast-enhanced computed tomography (CT) scans show heterogeneously enhancing mass in left upper lobe. Mass decreases in diameter from 3.1 to 2.1 cm and then marked increase to 3.4 cm on serial CT scans. D. Serial volume graph chart obtained from three-dimensional CT data using automated segmentation technique during follow-up shows wax-and-wane pattern. E, F. Mass shows iso- to higher signal intensity (SI) than that of muscle on T1-weighted magnetic resonance (MR) image (E) and heterogeneously high SI on fat-saturated T2-weighted image (F). G. Dynamic contrast-enhanced MR images and corresponding graph of SI versus time show early enhancement without peak point and subsequent plateau pattern. H. Gross findings show well-demarcated, solid mass with fibrous matrix and areas of hemorrhage. I. Well-demarcated mass with small cystic spaces filled with blood was observed on microscopic examination (hematoxylin and eosin staining, × 12.5).

Mentions: All laboratory findings were within normal limits. A round, well-circumscribed mass (approximate diameter, 3.3 cm) was observed in the left peri-hilar area on the chest radiograph. An initial contrast-enhanced chest CT scan (Fig. 1A) revealed a well-defined round mass (diameter, 3.1 cm) with heterogeneous enhancement in the left upper lobe. The mass showed a wax-and-wane growth pattern from October 2010 to October 2013 with diameters of 3.1, 2.1, 2.3, and 3.4 cm per annum, respectively (Fig. 1A-C). The volumes of the tumor measured on 3D CT using an automated segmentation technique were 15.8, 5.6, 6.7, and 20.0 cm3 per annum, respectively (Fig. 1D).


Sclerosing Pneumocytoma with a Wax-and-Wane Pattern of Growth: A Case Report on Computed Tomography and Magnetic Resonance Imaging Findings and a Literature Review.

Kim YP, Lee S, Park HS, Park CH, Kim TH - Korean J Radiol (2015)

Sclerosing pneumocytoma with wax-and-wane growth pattern in 47-year-old woman.A-C. Initial (A) and 1-year (B) and 3-year follow-up (C) contrast-enhanced computed tomography (CT) scans show heterogeneously enhancing mass in left upper lobe. Mass decreases in diameter from 3.1 to 2.1 cm and then marked increase to 3.4 cm on serial CT scans. D. Serial volume graph chart obtained from three-dimensional CT data using automated segmentation technique during follow-up shows wax-and-wane pattern. E, F. Mass shows iso- to higher signal intensity (SI) than that of muscle on T1-weighted magnetic resonance (MR) image (E) and heterogeneously high SI on fat-saturated T2-weighted image (F). G. Dynamic contrast-enhanced MR images and corresponding graph of SI versus time show early enhancement without peak point and subsequent plateau pattern. H. Gross findings show well-demarcated, solid mass with fibrous matrix and areas of hemorrhage. I. Well-demarcated mass with small cystic spaces filled with blood was observed on microscopic examination (hematoxylin and eosin staining, × 12.5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499563&req=5

Figure 1: Sclerosing pneumocytoma with wax-and-wane growth pattern in 47-year-old woman.A-C. Initial (A) and 1-year (B) and 3-year follow-up (C) contrast-enhanced computed tomography (CT) scans show heterogeneously enhancing mass in left upper lobe. Mass decreases in diameter from 3.1 to 2.1 cm and then marked increase to 3.4 cm on serial CT scans. D. Serial volume graph chart obtained from three-dimensional CT data using automated segmentation technique during follow-up shows wax-and-wane pattern. E, F. Mass shows iso- to higher signal intensity (SI) than that of muscle on T1-weighted magnetic resonance (MR) image (E) and heterogeneously high SI on fat-saturated T2-weighted image (F). G. Dynamic contrast-enhanced MR images and corresponding graph of SI versus time show early enhancement without peak point and subsequent plateau pattern. H. Gross findings show well-demarcated, solid mass with fibrous matrix and areas of hemorrhage. I. Well-demarcated mass with small cystic spaces filled with blood was observed on microscopic examination (hematoxylin and eosin staining, × 12.5).
Mentions: All laboratory findings were within normal limits. A round, well-circumscribed mass (approximate diameter, 3.3 cm) was observed in the left peri-hilar area on the chest radiograph. An initial contrast-enhanced chest CT scan (Fig. 1A) revealed a well-defined round mass (diameter, 3.1 cm) with heterogeneous enhancement in the left upper lobe. The mass showed a wax-and-wane growth pattern from October 2010 to October 2013 with diameters of 3.1, 2.1, 2.3, and 3.4 cm per annum, respectively (Fig. 1A-C). The volumes of the tumor measured on 3D CT using an automated segmentation technique were 15.8, 5.6, 6.7, and 20.0 cm3 per annum, respectively (Fig. 1D).

Bottom Line: Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm.Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman.We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.

ABSTRACT
Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm. Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman. Tumor diameter decreased over a 3-year follow-up period and then increased on serial follow-up computed tomography scans. The mass showed high signal intensity on both T1- and T2-weighted chest magnetic resonance imaging (MRI) and early enhancement with a plateau on dynamic MRI. We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.

No MeSH data available.


Related in: MedlinePlus