Limits...
Prediction of Pathologic Grade and Prognosis in Mucoepidermoid Carcinoma of the Lung Using ¹⁸F-FDG PET/CT.

Park B, Kim HK, Choi YS, Kim J, Zo JI, Choi JY, Shim YM - Korean J Radiol (2015)

Bottom Line: Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

ABSTRACT

Objective: The maximum standardized uptake value (SUVmax) of pulmonary mucoepidermoid carcinoma (PMEC) in fluorine-18fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was evaluated as a preoperative predictor of pathologic grade and survival rate.

Materials and methods: Twenty-three patients who underwent preoperative PET/CT and complete resection for PMEC were enrolled. The optimal cut-off SUVmax for tumor grade was calculated as 6.5 by receiver operating characteristic curve. The patients were divided into a high SUV group (n = 7) and a low SUV group (n = 16). Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.

Results: The mean SUVmax was 15.4 ± 11.5 in the high SUV group and 3.9 ± 1.3 in the low SUV group. All patients except one from the low SUV group had low grade tumors and all had no nodal metastasis. The sensitivity and specificity of SUVmax from PET/CT for predicting tumor grade was 85.7% and 93.8%, respectively. During the follow-up period (mean, 48.6 ± 38.7 months), four patients from the high SUV group experienced cancer recurrence, and one died of cancer. In contrast, none of the low SUV group had recurrence or mortality. Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).

Conclusion: Pulmonary mucoepidermoid carcinoma patients with high SUVmax in PET/CT had higher tumor grade, more frequent lymph node metastasis and worse long-term outcome. Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier overall and disease-free survival of 23 patients after complete resection for PMEC according to SUV group.Overall survival (A) was significantly higher in low SUV group than high SUV group (5-year survival rates of 100% vs. 71.4%, p = 0.031). Disease-free survival (B) was also significantly higher in low SUV group (3-year survival rates of 100% vs. 17.9%, p < 0.001). PMEC = pulmonary mucoepidermoid carcinoma, SUV = standardized uptake value
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4499560&req=5

Figure 5: Kaplan-Meier overall and disease-free survival of 23 patients after complete resection for PMEC according to SUV group.Overall survival (A) was significantly higher in low SUV group than high SUV group (5-year survival rates of 100% vs. 71.4%, p = 0.031). Disease-free survival (B) was also significantly higher in low SUV group (3-year survival rates of 100% vs. 17.9%, p < 0.001). PMEC = pulmonary mucoepidermoid carcinoma, SUV = standardized uptake value

Mentions: Length of follow-up was similar between the two groups (mean 48.6 ± 38.7 months; p = 0.660). In the high SUV group, four patients (57.1%) suffered cancer recurrence during follow-up, and one died of cancer 5 months after surgery. Another patient from high SUV group showed no evidence of cancer recurrence, but died of brain infarct during the follow-up. In contrast, none of the patients in the low SUV group experienced recurrence or mortality. As a result, the 5-year overall survival rate was significantly higher in the low SUV group than the high SUV group (100% vs. 71.4% respectively, p = 0.031). Three-year disease-free survival was also significantly higher in the low SUV group (100% vs. 17.9% respectively, p < 0.001). High grade tumor (p < 0.001), pathologic stage III (p < 0.001) and high SUV group (p < 0.001) were significant prognostic factors in univariate analysis. Multivariate analysis for long-term survival was unavailable, because there was no mortality or recurrence in patients with the low SUV group. Kaplan-Meier curves of overall and disease-free survival rates according to SUV group are diagrammed in Figure 5.


Prediction of Pathologic Grade and Prognosis in Mucoepidermoid Carcinoma of the Lung Using ¹⁸F-FDG PET/CT.

Park B, Kim HK, Choi YS, Kim J, Zo JI, Choi JY, Shim YM - Korean J Radiol (2015)

Kaplan-Meier overall and disease-free survival of 23 patients after complete resection for PMEC according to SUV group.Overall survival (A) was significantly higher in low SUV group than high SUV group (5-year survival rates of 100% vs. 71.4%, p = 0.031). Disease-free survival (B) was also significantly higher in low SUV group (3-year survival rates of 100% vs. 17.9%, p < 0.001). PMEC = pulmonary mucoepidermoid carcinoma, SUV = standardized uptake value
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499560&req=5

Figure 5: Kaplan-Meier overall and disease-free survival of 23 patients after complete resection for PMEC according to SUV group.Overall survival (A) was significantly higher in low SUV group than high SUV group (5-year survival rates of 100% vs. 71.4%, p = 0.031). Disease-free survival (B) was also significantly higher in low SUV group (3-year survival rates of 100% vs. 17.9%, p < 0.001). PMEC = pulmonary mucoepidermoid carcinoma, SUV = standardized uptake value
Mentions: Length of follow-up was similar between the two groups (mean 48.6 ± 38.7 months; p = 0.660). In the high SUV group, four patients (57.1%) suffered cancer recurrence during follow-up, and one died of cancer 5 months after surgery. Another patient from high SUV group showed no evidence of cancer recurrence, but died of brain infarct during the follow-up. In contrast, none of the patients in the low SUV group experienced recurrence or mortality. As a result, the 5-year overall survival rate was significantly higher in the low SUV group than the high SUV group (100% vs. 71.4% respectively, p = 0.031). Three-year disease-free survival was also significantly higher in the low SUV group (100% vs. 17.9% respectively, p < 0.001). High grade tumor (p < 0.001), pathologic stage III (p < 0.001) and high SUV group (p < 0.001) were significant prognostic factors in univariate analysis. Multivariate analysis for long-term survival was unavailable, because there was no mortality or recurrence in patients with the low SUV group. Kaplan-Meier curves of overall and disease-free survival rates according to SUV group are diagrammed in Figure 5.

Bottom Line: Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

ABSTRACT

Objective: The maximum standardized uptake value (SUVmax) of pulmonary mucoepidermoid carcinoma (PMEC) in fluorine-18fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was evaluated as a preoperative predictor of pathologic grade and survival rate.

Materials and methods: Twenty-three patients who underwent preoperative PET/CT and complete resection for PMEC were enrolled. The optimal cut-off SUVmax for tumor grade was calculated as 6.5 by receiver operating characteristic curve. The patients were divided into a high SUV group (n = 7) and a low SUV group (n = 16). Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.

Results: The mean SUVmax was 15.4 ± 11.5 in the high SUV group and 3.9 ± 1.3 in the low SUV group. All patients except one from the low SUV group had low grade tumors and all had no nodal metastasis. The sensitivity and specificity of SUVmax from PET/CT for predicting tumor grade was 85.7% and 93.8%, respectively. During the follow-up period (mean, 48.6 ± 38.7 months), four patients from the high SUV group experienced cancer recurrence, and one died of cancer. In contrast, none of the low SUV group had recurrence or mortality. Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).

Conclusion: Pulmonary mucoepidermoid carcinoma patients with high SUVmax in PET/CT had higher tumor grade, more frequent lymph node metastasis and worse long-term outcome. Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

No MeSH data available.


Related in: MedlinePlus