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Prediction of Pathologic Grade and Prognosis in Mucoepidermoid Carcinoma of the Lung Using ¹⁸F-FDG PET/CT.

Park B, Kim HK, Choi YS, Kim J, Zo JI, Choi JY, Shim YM - Korean J Radiol (2015)

Bottom Line: Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

ABSTRACT

Objective: The maximum standardized uptake value (SUVmax) of pulmonary mucoepidermoid carcinoma (PMEC) in fluorine-18fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was evaluated as a preoperative predictor of pathologic grade and survival rate.

Materials and methods: Twenty-three patients who underwent preoperative PET/CT and complete resection for PMEC were enrolled. The optimal cut-off SUVmax for tumor grade was calculated as 6.5 by receiver operating characteristic curve. The patients were divided into a high SUV group (n = 7) and a low SUV group (n = 16). Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.

Results: The mean SUVmax was 15.4 ± 11.5 in the high SUV group and 3.9 ± 1.3 in the low SUV group. All patients except one from the low SUV group had low grade tumors and all had no nodal metastasis. The sensitivity and specificity of SUVmax from PET/CT for predicting tumor grade was 85.7% and 93.8%, respectively. During the follow-up period (mean, 48.6 ± 38.7 months), four patients from the high SUV group experienced cancer recurrence, and one died of cancer. In contrast, none of the low SUV group had recurrence or mortality. Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).

Conclusion: Pulmonary mucoepidermoid carcinoma patients with high SUVmax in PET/CT had higher tumor grade, more frequent lymph node metastasis and worse long-term outcome. Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristics (ROCs) curve for maximum standardized uptake value (SUVmax) for prediction of tumor grade of pulmonary mucoepidermoid carcinoma.Optimal cut-off value of SUVmax from PET/CT was calculated as 6.5 by ROCs curve. Area under curve for SUVmax was 0.92 and sensitivity and specificity for predicting tumor grade were 85.7% and 93.8%, respectively. PET/CT = positron emission tomography/computed tomography
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Figure 1: Receiver operating characteristics (ROCs) curve for maximum standardized uptake value (SUVmax) for prediction of tumor grade of pulmonary mucoepidermoid carcinoma.Optimal cut-off value of SUVmax from PET/CT was calculated as 6.5 by ROCs curve. Area under curve for SUVmax was 0.92 and sensitivity and specificity for predicting tumor grade were 85.7% and 93.8%, respectively. PET/CT = positron emission tomography/computed tomography

Mentions: All data were statistically analyzed using Stata Statistical Software 2007, Version 10 (StataCorp LP, College Station, TX, USA). SUVmax of the main tumor in PET/CT images was correlated with tumor grade. The optimal cutoff value was calculated as 6.5 by receiver operating characteristic (ROC) curve and area under curve was 0.92. The ROC curve is diagrammed in Figure 1. Patients with a SUVmax of 6.5 or higher were assigned to the high SUV group (n = 7) and the rest were assigned to the low SUV group (n = 16). We compared tumor grade, pathologic stage, and long-term outcomes between the low SUV group and the high SUV group. χ2 tests were performed for categorical variables, and unpaired t tests were performed for continuous variables. Overall survival was analyzed with Kaplan-Meier curves and the log-rank test.


Prediction of Pathologic Grade and Prognosis in Mucoepidermoid Carcinoma of the Lung Using ¹⁸F-FDG PET/CT.

Park B, Kim HK, Choi YS, Kim J, Zo JI, Choi JY, Shim YM - Korean J Radiol (2015)

Receiver operating characteristics (ROCs) curve for maximum standardized uptake value (SUVmax) for prediction of tumor grade of pulmonary mucoepidermoid carcinoma.Optimal cut-off value of SUVmax from PET/CT was calculated as 6.5 by ROCs curve. Area under curve for SUVmax was 0.92 and sensitivity and specificity for predicting tumor grade were 85.7% and 93.8%, respectively. PET/CT = positron emission tomography/computed tomography
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499560&req=5

Figure 1: Receiver operating characteristics (ROCs) curve for maximum standardized uptake value (SUVmax) for prediction of tumor grade of pulmonary mucoepidermoid carcinoma.Optimal cut-off value of SUVmax from PET/CT was calculated as 6.5 by ROCs curve. Area under curve for SUVmax was 0.92 and sensitivity and specificity for predicting tumor grade were 85.7% and 93.8%, respectively. PET/CT = positron emission tomography/computed tomography
Mentions: All data were statistically analyzed using Stata Statistical Software 2007, Version 10 (StataCorp LP, College Station, TX, USA). SUVmax of the main tumor in PET/CT images was correlated with tumor grade. The optimal cutoff value was calculated as 6.5 by receiver operating characteristic (ROC) curve and area under curve was 0.92. The ROC curve is diagrammed in Figure 1. Patients with a SUVmax of 6.5 or higher were assigned to the high SUV group (n = 7) and the rest were assigned to the low SUV group (n = 16). We compared tumor grade, pathologic stage, and long-term outcomes between the low SUV group and the high SUV group. χ2 tests were performed for categorical variables, and unpaired t tests were performed for continuous variables. Overall survival was analyzed with Kaplan-Meier curves and the log-rank test.

Bottom Line: Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

ABSTRACT

Objective: The maximum standardized uptake value (SUVmax) of pulmonary mucoepidermoid carcinoma (PMEC) in fluorine-18fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was evaluated as a preoperative predictor of pathologic grade and survival rate.

Materials and methods: Twenty-three patients who underwent preoperative PET/CT and complete resection for PMEC were enrolled. The optimal cut-off SUVmax for tumor grade was calculated as 6.5 by receiver operating characteristic curve. The patients were divided into a high SUV group (n = 7) and a low SUV group (n = 16). Clinicopathologic features were compared between the groups by χ(2) test and overall survival was determined by Kaplan-Meier analysis.

Results: The mean SUVmax was 15.4 ± 11.5 in the high SUV group and 3.9 ± 1.3 in the low SUV group. All patients except one from the low SUV group had low grade tumors and all had no nodal metastasis. The sensitivity and specificity of SUVmax from PET/CT for predicting tumor grade was 85.7% and 93.8%, respectively. During the follow-up period (mean, 48.6 ± 38.7 months), four patients from the high SUV group experienced cancer recurrence, and one died of cancer. In contrast, none of the low SUV group had recurrence or mortality. Five-year overall survival rate was significantly higher in the low SUV group (100% vs. 71.4%, p = 0.031).

Conclusion: Pulmonary mucoepidermoid carcinoma patients with high SUVmax in PET/CT had higher tumor grade, more frequent lymph node metastasis and worse long-term outcome. Therefore, PMEC patients with high uptake on PET/CT imaging might require aggressive mediastinal lymph node dissection and adjuvant therapies.

No MeSH data available.


Related in: MedlinePlus