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Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia.

Choi HS, Ahn SS, Shin NY, Kim J, Kim JH, Lee JE, Lee HY, Heo JH, Lee SK - Korean J Radiol (2015)

Bottom Line: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil.All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue.Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

ABSTRACT

Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia.

Materials and methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue.

Results: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.

No MeSH data available.


Related in: MedlinePlus

Scatter plots and fitted linear correlation lines of optical density versus permeability parameters. Ktrans(A), ve(B), and vp(C).
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Figure 4: Scatter plots and fitted linear correlation lines of optical density versus permeability parameters. Ktrans(A), ve(B), and vp(C).

Mentions: Thirteen rats showed acute infarct in right basal ganglia or cortex on diffusion-weighted images. There were no cases showing hemorrhagic transformation on T2*-weighted gradient echo images. DCE-MRI showed an increase in permeability parameters in the ipsilateral hemisphere of the MCA occlusion (Fig. 3). There were no cases with a positive value of any permeability parameter in the contralateral normal-appearing hemisphere on DCE-MRI. All the permeability parameters showed a linear correlation with optical density (Table 1, Fig. 4). Among those permeability parameters, Ktrans showed the highest values of correlation coefficient and coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Durbin-Watson statistics for analysis of residuals showed 2.072, which was suggestive of normality and independence of residuals.


Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia.

Choi HS, Ahn SS, Shin NY, Kim J, Kim JH, Lee JE, Lee HY, Heo JH, Lee SK - Korean J Radiol (2015)

Scatter plots and fitted linear correlation lines of optical density versus permeability parameters. Ktrans(A), ve(B), and vp(C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499543&req=5

Figure 4: Scatter plots and fitted linear correlation lines of optical density versus permeability parameters. Ktrans(A), ve(B), and vp(C).
Mentions: Thirteen rats showed acute infarct in right basal ganglia or cortex on diffusion-weighted images. There were no cases showing hemorrhagic transformation on T2*-weighted gradient echo images. DCE-MRI showed an increase in permeability parameters in the ipsilateral hemisphere of the MCA occlusion (Fig. 3). There were no cases with a positive value of any permeability parameter in the contralateral normal-appearing hemisphere on DCE-MRI. All the permeability parameters showed a linear correlation with optical density (Table 1, Fig. 4). Among those permeability parameters, Ktrans showed the highest values of correlation coefficient and coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Durbin-Watson statistics for analysis of residuals showed 2.072, which was suggestive of normality and independence of residuals.

Bottom Line: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil.All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue.Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

ABSTRACT

Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia.

Materials and methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue.

Results: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.

No MeSH data available.


Related in: MedlinePlus