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Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia.

Choi HS, Ahn SS, Shin NY, Kim J, Kim JH, Lee JE, Lee HY, Heo JH, Lee SK - Korean J Radiol (2015)

Bottom Line: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil.All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue.Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

ABSTRACT

Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia.

Materials and methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue.

Results: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.

No MeSH data available.


Related in: MedlinePlus

Extravasation of Evans blue and Ktrans map.Extravasation of Evans blue was displayed on left column and Ktrans map on right column in 12 hours after reperfusion (A), 18 hours after reperfusion (B), and 36 hours after reperfusion (C).
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Figure 3: Extravasation of Evans blue and Ktrans map.Extravasation of Evans blue was displayed on left column and Ktrans map on right column in 12 hours after reperfusion (A), 18 hours after reperfusion (B), and 36 hours after reperfusion (C).

Mentions: Thirteen rats showed acute infarct in right basal ganglia or cortex on diffusion-weighted images. There were no cases showing hemorrhagic transformation on T2*-weighted gradient echo images. DCE-MRI showed an increase in permeability parameters in the ipsilateral hemisphere of the MCA occlusion (Fig. 3). There were no cases with a positive value of any permeability parameter in the contralateral normal-appearing hemisphere on DCE-MRI. All the permeability parameters showed a linear correlation with optical density (Table 1, Fig. 4). Among those permeability parameters, Ktrans showed the highest values of correlation coefficient and coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Durbin-Watson statistics for analysis of residuals showed 2.072, which was suggestive of normality and independence of residuals.


Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia.

Choi HS, Ahn SS, Shin NY, Kim J, Kim JH, Lee JE, Lee HY, Heo JH, Lee SK - Korean J Radiol (2015)

Extravasation of Evans blue and Ktrans map.Extravasation of Evans blue was displayed on left column and Ktrans map on right column in 12 hours after reperfusion (A), 18 hours after reperfusion (B), and 36 hours after reperfusion (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4499543&req=5

Figure 3: Extravasation of Evans blue and Ktrans map.Extravasation of Evans blue was displayed on left column and Ktrans map on right column in 12 hours after reperfusion (A), 18 hours after reperfusion (B), and 36 hours after reperfusion (C).
Mentions: Thirteen rats showed acute infarct in right basal ganglia or cortex on diffusion-weighted images. There were no cases showing hemorrhagic transformation on T2*-weighted gradient echo images. DCE-MRI showed an increase in permeability parameters in the ipsilateral hemisphere of the MCA occlusion (Fig. 3). There were no cases with a positive value of any permeability parameter in the contralateral normal-appearing hemisphere on DCE-MRI. All the permeability parameters showed a linear correlation with optical density (Table 1, Fig. 4). Among those permeability parameters, Ktrans showed the highest values of correlation coefficient and coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Durbin-Watson statistics for analysis of residuals showed 2.072, which was suggestive of normality and independence of residuals.

Bottom Line: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil.All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue.Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

ABSTRACT

Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia.

Materials and methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue.

Results: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001).

Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.

No MeSH data available.


Related in: MedlinePlus