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Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans.

Gambini J, Inglés M, Olaso G, Lopez-Grueso R, Bonet-Costa V, Gimeno-Mallench L, Mas-Bargues C, Abdelaziz KM, Gomez-Cabrera MC, Vina J, Borras C - Oxid Med Cell Longev (2015)

Bottom Line: Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years.It can be found in some plants, fruits, and derivatives, such as red wine.The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.

ABSTRACT
Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years. It can be found in some plants, fruits, and derivatives, such as red wine. Therefore, it can be administered by either consuming these natural products or intaking nutraceutical pills. Resveratrol exhibits a wide range of beneficial properties, and this may be due to its molecular structure, which endow resveratrol with the ability to bind to many biomolecules. Among these properties its activity as an anticancer agent, a platelet antiaggregation agent, and an antioxidant, as well as its antiaging, antifrailty, anti-inflammatory, antiallergenic, and so forth activities, is worth highlighting. These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo. The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. Clarifying aspects like stability and pharmacokinetics of resveratrol metabolites would be fundamental to understand and apply the therapeutic properties of resveratrol.

No MeSH data available.


Chemical structures of trans-resveratrol and cis-resveratrol.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Chemical structures of trans-resveratrol and cis-resveratrol.

Mentions: Resveratrol (3,5,4′-Trihydroxystilbene) is a natural polyphenol with a stilbene structure. Its chemical structure was characterized in 1940 by Takaoka, who isolated it from the root of Veratrum grandiflorum [1]. However, it has been present in medicinal preparations, such as darakchasava or manakka [2], for more than 2000 years. Its basic structure consists of two phenolic rings bonded together by a double styrene bond, which forms the 3,5,4′-Trihydroxystilbene (molecular weight 228.25 g/mol). This double bond is responsible for the isometric cis- and trans-forms of resveratrol (Figure 1). It is worth mentioning that the trans-isomer is the most stable from the steric point of view [3].


Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans.

Gambini J, Inglés M, Olaso G, Lopez-Grueso R, Bonet-Costa V, Gimeno-Mallench L, Mas-Bargues C, Abdelaziz KM, Gomez-Cabrera MC, Vina J, Borras C - Oxid Med Cell Longev (2015)

Chemical structures of trans-resveratrol and cis-resveratrol.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4499410&req=5

fig1: Chemical structures of trans-resveratrol and cis-resveratrol.
Mentions: Resveratrol (3,5,4′-Trihydroxystilbene) is a natural polyphenol with a stilbene structure. Its chemical structure was characterized in 1940 by Takaoka, who isolated it from the root of Veratrum grandiflorum [1]. However, it has been present in medicinal preparations, such as darakchasava or manakka [2], for more than 2000 years. Its basic structure consists of two phenolic rings bonded together by a double styrene bond, which forms the 3,5,4′-Trihydroxystilbene (molecular weight 228.25 g/mol). This double bond is responsible for the isometric cis- and trans-forms of resveratrol (Figure 1). It is worth mentioning that the trans-isomer is the most stable from the steric point of view [3].

Bottom Line: Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years.It can be found in some plants, fruits, and derivatives, such as red wine.The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.

ABSTRACT
Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years. It can be found in some plants, fruits, and derivatives, such as red wine. Therefore, it can be administered by either consuming these natural products or intaking nutraceutical pills. Resveratrol exhibits a wide range of beneficial properties, and this may be due to its molecular structure, which endow resveratrol with the ability to bind to many biomolecules. Among these properties its activity as an anticancer agent, a platelet antiaggregation agent, and an antioxidant, as well as its antiaging, antifrailty, anti-inflammatory, antiallergenic, and so forth activities, is worth highlighting. These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo. The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. Clarifying aspects like stability and pharmacokinetics of resveratrol metabolites would be fundamental to understand and apply the therapeutic properties of resveratrol.

No MeSH data available.