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Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease.

Takahashi Y, Kakizaki H - Int J Endocrinol (2015)

Bottom Line: The correlation between the dose-effect relationship and the hypothesized predictive factors was evaluated using stepwise multiple regression analysis.Results.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Aichi Medical University, Aichi 480-1195, Japan.

ABSTRACT
Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were retrospectively reviewed. We calculated the largest IRM cross-sectional area and evaluated the degree of adipose change in the IRM using magnetic resonance imaging. The degree of adipose change and smoking status were classified using grading scales (0-3); previous orbital radiotherapy was graded as 0 when a history was not available and 1 when it was available. The correlation between the dose-effect relationship and the hypothesized predictive factors was evaluated using stepwise multiple regression analysis. Results. The multiple regression model, with the exception of the history of the previous orbital radiotherapy, estimated a significant dose-effect relationship for the parameters evaluated (Y DOSE-EFFECT = 0.013X IRM AREA  - 0.222X ADIPOSE  - 0.102X SMOKING + 1.694; r = 0.668; adjusted r (2) = 0.367; P = 0.005). Conclusions. The dose-effect relationship regarding unilateral IRM recession in TED could be predicted using IRM thickness, degree of intramuscular adipose change, and smoking status but could not be predicted using the previous orbital radiotherapy history.

No MeSH data available.


Related in: MedlinePlus

Measurement of the thickness of the inferior rectus muscle (IRM). The major axis of the IRM (solid line) and the minor axis perpendicularly crossing the major axis on the surgical side (dotted line) are measured on the T1-weighted coronal magnetic resonance image showing the largest IRM cross-sectional area.
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fig1: Measurement of the thickness of the inferior rectus muscle (IRM). The major axis of the IRM (solid line) and the minor axis perpendicularly crossing the major axis on the surgical side (dotted line) are measured on the T1-weighted coronal magnetic resonance image showing the largest IRM cross-sectional area.

Mentions: IRM thickness was measured by one of the authors (Yasuhiro Takahashi) using the digital caliper tool of a viewer (ShadeQuest/ViewR, Yokogawa Medical Solutions Corporation, Tokyo, Japan). The major axis of the IRM on the surgical side was measured first on the T1-weighted MR image showing the largest IRM cross-sectional area (Figure 1). Next, the minor axis perpendicularly crossing the major axis was measured on the same MR image. We calculated the area of the largest IRM section, assumed to be an ellipse [12], as follows: (major axis/2) × (minor axis/2) × 3.14.


Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease.

Takahashi Y, Kakizaki H - Int J Endocrinol (2015)

Measurement of the thickness of the inferior rectus muscle (IRM). The major axis of the IRM (solid line) and the minor axis perpendicularly crossing the major axis on the surgical side (dotted line) are measured on the T1-weighted coronal magnetic resonance image showing the largest IRM cross-sectional area.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4499406&req=5

fig1: Measurement of the thickness of the inferior rectus muscle (IRM). The major axis of the IRM (solid line) and the minor axis perpendicularly crossing the major axis on the surgical side (dotted line) are measured on the T1-weighted coronal magnetic resonance image showing the largest IRM cross-sectional area.
Mentions: IRM thickness was measured by one of the authors (Yasuhiro Takahashi) using the digital caliper tool of a viewer (ShadeQuest/ViewR, Yokogawa Medical Solutions Corporation, Tokyo, Japan). The major axis of the IRM on the surgical side was measured first on the T1-weighted MR image showing the largest IRM cross-sectional area (Figure 1). Next, the minor axis perpendicularly crossing the major axis was measured on the same MR image. We calculated the area of the largest IRM section, assumed to be an ellipse [12], as follows: (major axis/2) × (minor axis/2) × 3.14.

Bottom Line: The correlation between the dose-effect relationship and the hypothesized predictive factors was evaluated using stepwise multiple regression analysis.Results.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Aichi Medical University, Aichi 480-1195, Japan.

ABSTRACT
Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were retrospectively reviewed. We calculated the largest IRM cross-sectional area and evaluated the degree of adipose change in the IRM using magnetic resonance imaging. The degree of adipose change and smoking status were classified using grading scales (0-3); previous orbital radiotherapy was graded as 0 when a history was not available and 1 when it was available. The correlation between the dose-effect relationship and the hypothesized predictive factors was evaluated using stepwise multiple regression analysis. Results. The multiple regression model, with the exception of the history of the previous orbital radiotherapy, estimated a significant dose-effect relationship for the parameters evaluated (Y DOSE-EFFECT = 0.013X IRM AREA  - 0.222X ADIPOSE  - 0.102X SMOKING + 1.694; r = 0.668; adjusted r (2) = 0.367; P = 0.005). Conclusions. The dose-effect relationship regarding unilateral IRM recession in TED could be predicted using IRM thickness, degree of intramuscular adipose change, and smoking status but could not be predicted using the previous orbital radiotherapy history.

No MeSH data available.


Related in: MedlinePlus