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Intervening TNF-α via PPARγ with Gegenqinlian Decoction in Experimental Nonalcoholic Fatty Liver Disease.

Wang YL, Liu LJ, Zhao WH, Li JX - Evid Based Complement Alternat Med (2015)

Bottom Line: This paper is to explore the effect and mechanism of Gegenqinlian decoction on experimental nonalcoholic fatty liver disease (NAFLD) in vivo and in vitro.The final aim is to make clear whether Gegenqinlian decoction would impact NAFLD through improving PPARγ to suppress inflammation and regulate lipid.The data in this research suggested that Gegenqinlian decoction is a potent way to manage NAFLD through improving PPARγ to regulate lipid and suppress inflammation.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.

ABSTRACT
This paper is to explore the effect and mechanism of Gegenqinlian decoction on experimental nonalcoholic fatty liver disease (NAFLD) in vivo and in vitro. The final aim is to make clear whether Gegenqinlian decoction would impact NAFLD through improving PPARγ to suppress inflammation and regulate lipid. The data in this research suggested that Gegenqinlian decoction is a potent way to manage NAFLD through improving PPARγ to regulate lipid and suppress inflammation.

No MeSH data available.


Related in: MedlinePlus

The results of paraffin section and H&E staining in vivo, ×400. (a) Chow fed rat, (b) HFD model rats, (c) GGQLDL treatment rats, (d) GGQLDH treatment rats, and (e) ROS treatment rats.
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fig3: The results of paraffin section and H&E staining in vivo, ×400. (a) Chow fed rat, (b) HFD model rats, (c) GGQLDL treatment rats, (d) GGQLDH treatment rats, and (e) ROS treatment rats.

Mentions: The photomicrographs of the H&E stain showed that HFD feeding increased hepatic fat deposits, evidenced by the majority of the hepatocytes of HFD rats that were distended by fat in comparison to the chow group (Figures 3(b) and 3(a)). The images of H&E stain also displayed steatosis and ballooning degeneration and evident infiltration with inflammatory cells in the intercellular substance, causing conspicuous swelling of the cell and cytoplasmic vacuolation as shown in Figure 3(b). The treatment of HFD rats with GGQLDs and rosiglitazone reduced fat deposits in liver (Figures 3(c), 3(d), and 3(e)) and the GGQLDs showed histological features similar to the chow group with little steatosis as shown in Figures 3(c) and 3(d).


Intervening TNF-α via PPARγ with Gegenqinlian Decoction in Experimental Nonalcoholic Fatty Liver Disease.

Wang YL, Liu LJ, Zhao WH, Li JX - Evid Based Complement Alternat Med (2015)

The results of paraffin section and H&E staining in vivo, ×400. (a) Chow fed rat, (b) HFD model rats, (c) GGQLDL treatment rats, (d) GGQLDH treatment rats, and (e) ROS treatment rats.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4499399&req=5

fig3: The results of paraffin section and H&E staining in vivo, ×400. (a) Chow fed rat, (b) HFD model rats, (c) GGQLDL treatment rats, (d) GGQLDH treatment rats, and (e) ROS treatment rats.
Mentions: The photomicrographs of the H&E stain showed that HFD feeding increased hepatic fat deposits, evidenced by the majority of the hepatocytes of HFD rats that were distended by fat in comparison to the chow group (Figures 3(b) and 3(a)). The images of H&E stain also displayed steatosis and ballooning degeneration and evident infiltration with inflammatory cells in the intercellular substance, causing conspicuous swelling of the cell and cytoplasmic vacuolation as shown in Figure 3(b). The treatment of HFD rats with GGQLDs and rosiglitazone reduced fat deposits in liver (Figures 3(c), 3(d), and 3(e)) and the GGQLDs showed histological features similar to the chow group with little steatosis as shown in Figures 3(c) and 3(d).

Bottom Line: This paper is to explore the effect and mechanism of Gegenqinlian decoction on experimental nonalcoholic fatty liver disease (NAFLD) in vivo and in vitro.The final aim is to make clear whether Gegenqinlian decoction would impact NAFLD through improving PPARγ to suppress inflammation and regulate lipid.The data in this research suggested that Gegenqinlian decoction is a potent way to manage NAFLD through improving PPARγ to regulate lipid and suppress inflammation.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.

ABSTRACT
This paper is to explore the effect and mechanism of Gegenqinlian decoction on experimental nonalcoholic fatty liver disease (NAFLD) in vivo and in vitro. The final aim is to make clear whether Gegenqinlian decoction would impact NAFLD through improving PPARγ to suppress inflammation and regulate lipid. The data in this research suggested that Gegenqinlian decoction is a potent way to manage NAFLD through improving PPARγ to regulate lipid and suppress inflammation.

No MeSH data available.


Related in: MedlinePlus