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Higher plasma prorenin concentration plays a role in the development of coronary artery disease.

Yoshida G, Kawasaki M, Murata I, Hayakawa Y, Aoyama T, Miyazaki N, Yamada Y, Nishigaki K, Arai Y, Suzuki F, Minatoguchi S - Biomark Res (2015)

Bottom Line: There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group.The plasma prorenin concentration increases with increases in plasma renin concentration.Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Gifu University Graduate School of Medicine, Gifu, Japan.

ABSTRACT

Background: Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to examine the relationships among plasma prorenin concentration, CAD and clinical parameters.

Methods: We measured plasma prorenin and renin concentrations and other parameters in 85 patients who underwent coronary angiography. Patients were divided into a CAD group (≥75 % stenosis in one or more coronary arteries) and a non-CAD group.

Results: There was a weak correlation between prorenin and plasma renin concentration (r =0.35, p =0.001), and plasma renin activity (r =0.34, p =0.001). There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group. However, patients with a high plasma prorenin concentration frequently suffered CAD. Receiver-operating-characteristic curve analysis showed that the optimal cutoff value of plasma prorenin concentration to detect CAD was 1,100 pg/ml, with a positive predictive value of 94 % and a negative predictive value of 36 %.

Conclusion: The plasma prorenin concentration increases with increases in plasma renin concentration. Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD.

No MeSH data available.


Related in: MedlinePlus

Plasma prorenin concentrations and renin activity in coronary artery disease and non- coronary artery disease groups. Non-parametric data are shown in box plots. A line in each box indicates the median. The upper and lower limits of each box are the 1st and 3rd quartiles, respectively
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Fig2: Plasma prorenin concentrations and renin activity in coronary artery disease and non- coronary artery disease groups. Non-parametric data are shown in box plots. A line in each box indicates the median. The upper and lower limits of each box are the 1st and 3rd quartiles, respectively

Mentions: There was also no significant difference in the plasma renin activity or plasma prorenin concentration between the CAD group and non-CAD group (Fig. 2). There was also no significant difference in the plasma prorenin concentration between patients with and without DM (635 ± 541 and 824 ± 533 pg/ml, respectively). There were also no significant differences in the plasma prorenin concentration in the patients with one-vessel disease, two-vessel disease and three-vessel disease (780 ± 681, 651 ± 507 and 884 ± 580 pg/ml, respectively). However, patients with a high plasma prorenin concentration frequently suffered from CAD (Fig. 2). Receiver-operating-characteristics curve analysis showed that the optimal cutoff value of the plasma prorenin concentration to detect CAD was 1,100 pg/ml with a positive predictive value for estimating CAD of 94 % and a negative predictive value of 36 % (Table 3) (Fig. 3). Only one of 26 patients with elevated plasma prorenin concentration (>1,100 pg/ml) did not have CAD (Fig. 2). The optimal cutoff value of the plasma renin activity to detect CAD was 0.8 ng/ml/hr with a positive predictive value of 72 %, and a negative predictive value of 32 %. A higher plasma prorenin concentration was more accurate than a higher PRA for the detection of CAD. Laboratory and clinical characteristics in the CAD group with patients stratified based on prorenin levels are shown in Table 4.Fig. 2


Higher plasma prorenin concentration plays a role in the development of coronary artery disease.

Yoshida G, Kawasaki M, Murata I, Hayakawa Y, Aoyama T, Miyazaki N, Yamada Y, Nishigaki K, Arai Y, Suzuki F, Minatoguchi S - Biomark Res (2015)

Plasma prorenin concentrations and renin activity in coronary artery disease and non- coronary artery disease groups. Non-parametric data are shown in box plots. A line in each box indicates the median. The upper and lower limits of each box are the 1st and 3rd quartiles, respectively
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4499175&req=5

Fig2: Plasma prorenin concentrations and renin activity in coronary artery disease and non- coronary artery disease groups. Non-parametric data are shown in box plots. A line in each box indicates the median. The upper and lower limits of each box are the 1st and 3rd quartiles, respectively
Mentions: There was also no significant difference in the plasma renin activity or plasma prorenin concentration between the CAD group and non-CAD group (Fig. 2). There was also no significant difference in the plasma prorenin concentration between patients with and without DM (635 ± 541 and 824 ± 533 pg/ml, respectively). There were also no significant differences in the plasma prorenin concentration in the patients with one-vessel disease, two-vessel disease and three-vessel disease (780 ± 681, 651 ± 507 and 884 ± 580 pg/ml, respectively). However, patients with a high plasma prorenin concentration frequently suffered from CAD (Fig. 2). Receiver-operating-characteristics curve analysis showed that the optimal cutoff value of the plasma prorenin concentration to detect CAD was 1,100 pg/ml with a positive predictive value for estimating CAD of 94 % and a negative predictive value of 36 % (Table 3) (Fig. 3). Only one of 26 patients with elevated plasma prorenin concentration (>1,100 pg/ml) did not have CAD (Fig. 2). The optimal cutoff value of the plasma renin activity to detect CAD was 0.8 ng/ml/hr with a positive predictive value of 72 %, and a negative predictive value of 32 %. A higher plasma prorenin concentration was more accurate than a higher PRA for the detection of CAD. Laboratory and clinical characteristics in the CAD group with patients stratified based on prorenin levels are shown in Table 4.Fig. 2

Bottom Line: There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group.The plasma prorenin concentration increases with increases in plasma renin concentration.Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Gifu University Graduate School of Medicine, Gifu, Japan.

ABSTRACT

Background: Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to examine the relationships among plasma prorenin concentration, CAD and clinical parameters.

Methods: We measured plasma prorenin and renin concentrations and other parameters in 85 patients who underwent coronary angiography. Patients were divided into a CAD group (≥75 % stenosis in one or more coronary arteries) and a non-CAD group.

Results: There was a weak correlation between prorenin and plasma renin concentration (r =0.35, p =0.001), and plasma renin activity (r =0.34, p =0.001). There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group. However, patients with a high plasma prorenin concentration frequently suffered CAD. Receiver-operating-characteristic curve analysis showed that the optimal cutoff value of plasma prorenin concentration to detect CAD was 1,100 pg/ml, with a positive predictive value of 94 % and a negative predictive value of 36 %.

Conclusion: The plasma prorenin concentration increases with increases in plasma renin concentration. Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD.

No MeSH data available.


Related in: MedlinePlus