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Magnetic Resonance Imaging Characteristics of Ovarian Clear Cell Carcinoma.

Wang W, Ding J, Zhu X, Li Y, Gu Y, Peng W - PLoS ONE (2015)

Bottom Line: To probe the magnetic resonance imaging (MRI) features of ovarian clear cell carcinoma (OCCC).Most solid protrusions were irregular and few in number and exhibited heterogeneous intermediate SI on T1WIs and T2WIs and prolonged enhanced SI in the contrast study.On MRI, OCCCs present as large unilateral multilocular or unilocular cystic masses with irregular intermediate SI solid protrusions or predominantly solid masses with cysts or necrosis at an early FIGO stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

ABSTRACT

Purpose: To probe the magnetic resonance imaging (MRI) features of ovarian clear cell carcinoma (OCCC).

Methods: This study retrospectively collected MRI data for 21 pathology-confirmed OCCCs from 19 female patients. The MRI findings were analyzed to determine the tumor size, shape/edge, shape and number of protrusions within the cyst, cystic or necrotic components, signal intensity (SI) and enhancement features.

Results: The age of the 19 patients ranged from 28 to 63 years (mean age: 53 years). Unilateral tumors were found in 17 patients (17/19, 89%); the average size of all tumors was 10.8 cm. The tumors on MRI were classified into two categories: (a) "cystic adnexal mass with solid protrusions" in 12 (57%) and (b) "solid adnexal mass with cystic areas or necrosis" in 9 (43%). For group a, high to very high SI was observed for most tumors (10/12, 83%) on T1-weighted images (T1WIs), and very high SI was observed on T2-weighted images (T2WIs) for all 12 tumors. Most solid protrusions were irregular and few in number and exhibited heterogeneous intermediate SI on T1WIs and T2WIs and prolonged enhanced SI in the contrast study. All 9 OCCCs in group b were predominantly solid masses with unequally sized necrotic or cystic areas in which some cysts were located at the periphery of the tumor (4/9, 44%). The solid components in all 9 tumors showed iso- or slightly high SI on T1WIs, heterogeneous iso-high SI on T2WIs and heterogeneous prolonged enhancement. According to FIGO classification, 14 tumors (14/19, 74%) were stages I-II, and 5 (5/19, 26%) were stages III-IV.

Conclusions: On MRI, OCCCs present as large unilateral multilocular or unilocular cystic masses with irregular intermediate SI solid protrusions or predominantly solid masses with cysts or necrosis at an early FIGO stage.

No MeSH data available.


Related in: MedlinePlus

An OCCC in a 59-year-old woman (Patient 7 in Tables 1 and 2) with frequent and urgent micturition and a pelvic lump.A-C Axial (A), coronal T2WI (B) and plain (non-contrast) T1WI (C) showing a large and irregular unilateral, multilocular well-defined cystic mass with many irregularities and a few oval lumen solid protrusions. The septations were < 3 mm (arrow). The SI of the cyst was very high on T2WIs and high on T1WI. The solid protrusions had heterogeneous intermediate SI on T2WIs and T1WI (A-C). D, E Enhanced T1WIs showing markedly heterogeneous and prolonged enhancement solid protrusions, with nonenhanced portions (arrow) indicating effusion, as shown by pathology results. The thickened wall was enhanced. F The tumor shows a solid pattern with clear cells. (HE 40 & 10).
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pone.0132406.g001: An OCCC in a 59-year-old woman (Patient 7 in Tables 1 and 2) with frequent and urgent micturition and a pelvic lump.A-C Axial (A), coronal T2WI (B) and plain (non-contrast) T1WI (C) showing a large and irregular unilateral, multilocular well-defined cystic mass with many irregularities and a few oval lumen solid protrusions. The septations were < 3 mm (arrow). The SI of the cyst was very high on T2WIs and high on T1WI. The solid protrusions had heterogeneous intermediate SI on T2WIs and T1WI (A-C). D, E Enhanced T1WIs showing markedly heterogeneous and prolonged enhancement solid protrusions, with nonenhanced portions (arrow) indicating effusion, as shown by pathology results. The thickened wall was enhanced. F The tumor shows a solid pattern with clear cells. (HE 40 & 10).

Mentions: The MRI characteristics of 21 OCCCs in 19 patients are summarized in Table 2, and representative patients are illustrated in Figs 1 to 4.


Magnetic Resonance Imaging Characteristics of Ovarian Clear Cell Carcinoma.

Wang W, Ding J, Zhu X, Li Y, Gu Y, Peng W - PLoS ONE (2015)

An OCCC in a 59-year-old woman (Patient 7 in Tables 1 and 2) with frequent and urgent micturition and a pelvic lump.A-C Axial (A), coronal T2WI (B) and plain (non-contrast) T1WI (C) showing a large and irregular unilateral, multilocular well-defined cystic mass with many irregularities and a few oval lumen solid protrusions. The septations were < 3 mm (arrow). The SI of the cyst was very high on T2WIs and high on T1WI. The solid protrusions had heterogeneous intermediate SI on T2WIs and T1WI (A-C). D, E Enhanced T1WIs showing markedly heterogeneous and prolonged enhancement solid protrusions, with nonenhanced portions (arrow) indicating effusion, as shown by pathology results. The thickened wall was enhanced. F The tumor shows a solid pattern with clear cells. (HE 40 & 10).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4498632&req=5

pone.0132406.g001: An OCCC in a 59-year-old woman (Patient 7 in Tables 1 and 2) with frequent and urgent micturition and a pelvic lump.A-C Axial (A), coronal T2WI (B) and plain (non-contrast) T1WI (C) showing a large and irregular unilateral, multilocular well-defined cystic mass with many irregularities and a few oval lumen solid protrusions. The septations were < 3 mm (arrow). The SI of the cyst was very high on T2WIs and high on T1WI. The solid protrusions had heterogeneous intermediate SI on T2WIs and T1WI (A-C). D, E Enhanced T1WIs showing markedly heterogeneous and prolonged enhancement solid protrusions, with nonenhanced portions (arrow) indicating effusion, as shown by pathology results. The thickened wall was enhanced. F The tumor shows a solid pattern with clear cells. (HE 40 & 10).
Mentions: The MRI characteristics of 21 OCCCs in 19 patients are summarized in Table 2, and representative patients are illustrated in Figs 1 to 4.

Bottom Line: To probe the magnetic resonance imaging (MRI) features of ovarian clear cell carcinoma (OCCC).Most solid protrusions were irregular and few in number and exhibited heterogeneous intermediate SI on T1WIs and T2WIs and prolonged enhanced SI in the contrast study.On MRI, OCCCs present as large unilateral multilocular or unilocular cystic masses with irregular intermediate SI solid protrusions or predominantly solid masses with cysts or necrosis at an early FIGO stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

ABSTRACT

Purpose: To probe the magnetic resonance imaging (MRI) features of ovarian clear cell carcinoma (OCCC).

Methods: This study retrospectively collected MRI data for 21 pathology-confirmed OCCCs from 19 female patients. The MRI findings were analyzed to determine the tumor size, shape/edge, shape and number of protrusions within the cyst, cystic or necrotic components, signal intensity (SI) and enhancement features.

Results: The age of the 19 patients ranged from 28 to 63 years (mean age: 53 years). Unilateral tumors were found in 17 patients (17/19, 89%); the average size of all tumors was 10.8 cm. The tumors on MRI were classified into two categories: (a) "cystic adnexal mass with solid protrusions" in 12 (57%) and (b) "solid adnexal mass with cystic areas or necrosis" in 9 (43%). For group a, high to very high SI was observed for most tumors (10/12, 83%) on T1-weighted images (T1WIs), and very high SI was observed on T2-weighted images (T2WIs) for all 12 tumors. Most solid protrusions were irregular and few in number and exhibited heterogeneous intermediate SI on T1WIs and T2WIs and prolonged enhanced SI in the contrast study. All 9 OCCCs in group b were predominantly solid masses with unequally sized necrotic or cystic areas in which some cysts were located at the periphery of the tumor (4/9, 44%). The solid components in all 9 tumors showed iso- or slightly high SI on T1WIs, heterogeneous iso-high SI on T2WIs and heterogeneous prolonged enhancement. According to FIGO classification, 14 tumors (14/19, 74%) were stages I-II, and 5 (5/19, 26%) were stages III-IV.

Conclusions: On MRI, OCCCs present as large unilateral multilocular or unilocular cystic masses with irregular intermediate SI solid protrusions or predominantly solid masses with cysts or necrosis at an early FIGO stage.

No MeSH data available.


Related in: MedlinePlus