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Endocarditis due to Coccidioides spp: The Seventh Case.

Horng LM, Yaghoubian S, Ram A, Johnson R, Castro L, Kuo J, Deresinski S - Open Forum Infect Dis (2015)

Bottom Line: Coccidioides, a dimorphic fungus endemic within the Americas, primarily causes pulmonary disease but may disseminate.We describe a case of confirmed Coccidioides endocarditis, the seventh reported in literature.Coccidioides endocarditis often requires tissue diagnosis and combined surgical and medical treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases and Geographic Medicine , Stanford University , California.

ABSTRACT
Coccidioides, a dimorphic fungus endemic within the Americas, primarily causes pulmonary disease but may disseminate. We describe a case of confirmed Coccidioides endocarditis, the seventh reported in literature. Coccidioides endocarditis often requires tissue diagnosis and combined surgical and medical treatment.

No MeSH data available.


Related in: MedlinePlus

Pathology of periaortic and valvular tissue: (A) granulomatous inflammation by hematoxylin and eosin (H&E) stain, (B) multinucleation and Coccidioides spherule by H&E stain, and (C) endosporulating Coccidioides by Periodic acid-Schiff stain.
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OFV086F2: Pathology of periaortic and valvular tissue: (A) granulomatous inflammation by hematoxylin and eosin (H&E) stain, (B) multinucleation and Coccidioides spherule by H&E stain, and (C) endosporulating Coccidioides by Periodic acid-Schiff stain.

Mentions: Aortic valve replacement was successfully accomplished. Histology showed granulomatous inflammation, multinucleation, and endosporulating spherules consistent with Coccidioides (Figure 2). Culture grew 1 fungal colony identified by DNA probe as Coccidioides spp. Coccidioides complement fixation titers were 1:8 before surgery and 1:2 after surgery plus 7 months of posaconazole therapy. The patient continues to receive posaconazole, which will be continued indefinitely with monitoring of symptoms, CF titers, and posaconazole levels every 3 months.Figure 2.


Endocarditis due to Coccidioides spp: The Seventh Case.

Horng LM, Yaghoubian S, Ram A, Johnson R, Castro L, Kuo J, Deresinski S - Open Forum Infect Dis (2015)

Pathology of periaortic and valvular tissue: (A) granulomatous inflammation by hematoxylin and eosin (H&E) stain, (B) multinucleation and Coccidioides spherule by H&E stain, and (C) endosporulating Coccidioides by Periodic acid-Schiff stain.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4498286&req=5

OFV086F2: Pathology of periaortic and valvular tissue: (A) granulomatous inflammation by hematoxylin and eosin (H&E) stain, (B) multinucleation and Coccidioides spherule by H&E stain, and (C) endosporulating Coccidioides by Periodic acid-Schiff stain.
Mentions: Aortic valve replacement was successfully accomplished. Histology showed granulomatous inflammation, multinucleation, and endosporulating spherules consistent with Coccidioides (Figure 2). Culture grew 1 fungal colony identified by DNA probe as Coccidioides spp. Coccidioides complement fixation titers were 1:8 before surgery and 1:2 after surgery plus 7 months of posaconazole therapy. The patient continues to receive posaconazole, which will be continued indefinitely with monitoring of symptoms, CF titers, and posaconazole levels every 3 months.Figure 2.

Bottom Line: Coccidioides, a dimorphic fungus endemic within the Americas, primarily causes pulmonary disease but may disseminate.We describe a case of confirmed Coccidioides endocarditis, the seventh reported in literature.Coccidioides endocarditis often requires tissue diagnosis and combined surgical and medical treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases and Geographic Medicine , Stanford University , California.

ABSTRACT
Coccidioides, a dimorphic fungus endemic within the Americas, primarily causes pulmonary disease but may disseminate. We describe a case of confirmed Coccidioides endocarditis, the seventh reported in literature. Coccidioides endocarditis often requires tissue diagnosis and combined surgical and medical treatment.

No MeSH data available.


Related in: MedlinePlus