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Fetuin-A as a predicator of sarcopenic left ventricular dysfunction.

Chang WT, Tsai WC, Wu CH, Lee YW, Tai YL, Li YH, Tsai LM, Chen JH, Liu PY - Sci Rep (2015)

Bottom Line: Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD).Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD.In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

View Article: PubMed Central - PubMed

Affiliation: 1] Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan [3] Division of Cardiovascular Medicine, Chi-Mei Medical Center, Tainan, Taiwan.

ABSTRACT
Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥ 65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17%) patients (79 ± 6 years; male: 34.7%) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50%) and 23 (4.3%) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

No MeSH data available.


Related in: MedlinePlus

Fetuin-A (FetA) serum concentrations negatively correlated with left ventricular ejection faction (LVEF), significantly in the sarcopenic population.(A) all geriatric participants; (B) in the sarcopenic sub-population and (C) in the non-sarcopenic subpopulation.
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f3: Fetuin-A (FetA) serum concentrations negatively correlated with left ventricular ejection faction (LVEF), significantly in the sarcopenic population.(A) all geriatric participants; (B) in the sarcopenic sub-population and (C) in the non-sarcopenic subpopulation.

Mentions: In this geriatric population, the mean value of serum FetA levels was 633.0 mg/L, which was not different by gender (626.1 ± 149.5; 640.5 ± 150.7 mg/L, respectively; p = 0.19) (data not shown). To test the pathophysiologic role of FetA in sarcopenia and heart function, we compared 4 subgroups using the quartiles of FetA (Fig. 2A–F). With a similar disease background, the prevalence of sarcopenia and S-LVD increased with incrementing FetA quartiles. To compare the interplay between FetA and heart function, the association between FetA level and LVEF was echocardiographically analyzed. Interestingly, although the LVEF value was not strongly correlated with the increased quartiles of FetA in the entire study population, the LVEF value was significantly negatively correlated with the FetA level in the sarcopenic group (R2 = 0.45, p < 0.001), but not in the non-sarcopenic group (R2 = 0.15, p = 0.2) (Fig. 3A–C), which implied the importance of the co-existence of sarcopenia in the link between FetA and LV dysfunction.


Fetuin-A as a predicator of sarcopenic left ventricular dysfunction.

Chang WT, Tsai WC, Wu CH, Lee YW, Tai YL, Li YH, Tsai LM, Chen JH, Liu PY - Sci Rep (2015)

Fetuin-A (FetA) serum concentrations negatively correlated with left ventricular ejection faction (LVEF), significantly in the sarcopenic population.(A) all geriatric participants; (B) in the sarcopenic sub-population and (C) in the non-sarcopenic subpopulation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4498243&req=5

f3: Fetuin-A (FetA) serum concentrations negatively correlated with left ventricular ejection faction (LVEF), significantly in the sarcopenic population.(A) all geriatric participants; (B) in the sarcopenic sub-population and (C) in the non-sarcopenic subpopulation.
Mentions: In this geriatric population, the mean value of serum FetA levels was 633.0 mg/L, which was not different by gender (626.1 ± 149.5; 640.5 ± 150.7 mg/L, respectively; p = 0.19) (data not shown). To test the pathophysiologic role of FetA in sarcopenia and heart function, we compared 4 subgroups using the quartiles of FetA (Fig. 2A–F). With a similar disease background, the prevalence of sarcopenia and S-LVD increased with incrementing FetA quartiles. To compare the interplay between FetA and heart function, the association between FetA level and LVEF was echocardiographically analyzed. Interestingly, although the LVEF value was not strongly correlated with the increased quartiles of FetA in the entire study population, the LVEF value was significantly negatively correlated with the FetA level in the sarcopenic group (R2 = 0.45, p < 0.001), but not in the non-sarcopenic group (R2 = 0.15, p = 0.2) (Fig. 3A–C), which implied the importance of the co-existence of sarcopenia in the link between FetA and LV dysfunction.

Bottom Line: Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD).Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD.In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

View Article: PubMed Central - PubMed

Affiliation: 1] Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan [3] Division of Cardiovascular Medicine, Chi-Mei Medical Center, Tainan, Taiwan.

ABSTRACT
Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥ 65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17%) patients (79 ± 6 years; male: 34.7%) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50%) and 23 (4.3%) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

No MeSH data available.


Related in: MedlinePlus