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Association of three 8q24 polymorphisms with prostate cancer susceptibility: evidence from a meta-analysis with 50,854 subjects.

Li Q, Liu X, Hua RX, Wang F, An H, Zhang W, Zhu JH - Sci Rep (2015)

Bottom Line: Overall, each of studied 8q24 polymorphisms was significantly associated with PCa risk individually.Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.The effect of rs16901979 was more prominent among Africa-Americans than Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.

ABSTRACT
The 8q24 polymorphisms have been implicated in various cancers. Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory. We conducted a comprehensive meta-analysis to reevaluate the associations between those polymorphisms and PCa susceptibility, according to the latest meta-analysis guidelines (PRISMA). Eligible publications were searched from MEDLINE, EMBASE and CBM. False positive report possibility analysis was performed. We totally collected 20184 cases and 20439 controls from 20 studies for the rs1447295 C>A, 1850 cases and 2090 controls from 7 studies for the rs16901979 C>A, and 12233 cases and 7582 controls from 17 studies for the rs6983267 T>G. Overall, each of studied 8q24 polymorphisms was significantly associated with PCa risk individually. Significant associations were also observed in stratified analysis by ethnicity, source of control, and quality score. Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans. The effect of rs16901979 was more prominent among Africa-Americans than Asians. Likewise, rs6983267 conferred a higher Pca risk among Caucasians than Asians. Collectively, these 8q24 variant(s) may modulate PCa risk in an ethnic-specific manner.

No MeSH data available.


Related in: MedlinePlus

Funnel plot analysis to detect publication bias for each of the 8q24 polymorphism by homozygous model.(A) For rs1447295 polymorphism, (B) For rs16901979 polymorphism, and (C) For rs6983267 polymorphism. Each point represented an individual study for the indicated association.
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f2: Funnel plot analysis to detect publication bias for each of the 8q24 polymorphism by homozygous model.(A) For rs1447295 polymorphism, (B) For rs16901979 polymorphism, and (C) For rs6983267 polymorphism. Each point represented an individual study for the indicated association.

Mentions: Publication bias was examined by Begg’s funnel plots and Egger’s tests across all genetic models for each of the three polymorphisms in the 8q24 region. The shape of funnel plot (Fig. 2) was symmetrical, suggesting that there was no evidence of publication bias in the meta-analysis.


Association of three 8q24 polymorphisms with prostate cancer susceptibility: evidence from a meta-analysis with 50,854 subjects.

Li Q, Liu X, Hua RX, Wang F, An H, Zhang W, Zhu JH - Sci Rep (2015)

Funnel plot analysis to detect publication bias for each of the 8q24 polymorphism by homozygous model.(A) For rs1447295 polymorphism, (B) For rs16901979 polymorphism, and (C) For rs6983267 polymorphism. Each point represented an individual study for the indicated association.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4498192&req=5

f2: Funnel plot analysis to detect publication bias for each of the 8q24 polymorphism by homozygous model.(A) For rs1447295 polymorphism, (B) For rs16901979 polymorphism, and (C) For rs6983267 polymorphism. Each point represented an individual study for the indicated association.
Mentions: Publication bias was examined by Begg’s funnel plots and Egger’s tests across all genetic models for each of the three polymorphisms in the 8q24 region. The shape of funnel plot (Fig. 2) was symmetrical, suggesting that there was no evidence of publication bias in the meta-analysis.

Bottom Line: Overall, each of studied 8q24 polymorphisms was significantly associated with PCa risk individually.Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.The effect of rs16901979 was more prominent among Africa-Americans than Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi, Xinjiang, 830054, China.

ABSTRACT
The 8q24 polymorphisms have been implicated in various cancers. Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory. We conducted a comprehensive meta-analysis to reevaluate the associations between those polymorphisms and PCa susceptibility, according to the latest meta-analysis guidelines (PRISMA). Eligible publications were searched from MEDLINE, EMBASE and CBM. False positive report possibility analysis was performed. We totally collected 20184 cases and 20439 controls from 20 studies for the rs1447295 C>A, 1850 cases and 2090 controls from 7 studies for the rs16901979 C>A, and 12233 cases and 7582 controls from 17 studies for the rs6983267 T>G. Overall, each of studied 8q24 polymorphisms was significantly associated with PCa risk individually. Significant associations were also observed in stratified analysis by ethnicity, source of control, and quality score. Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans. The effect of rs16901979 was more prominent among Africa-Americans than Asians. Likewise, rs6983267 conferred a higher Pca risk among Caucasians than Asians. Collectively, these 8q24 variant(s) may modulate PCa risk in an ethnic-specific manner.

No MeSH data available.


Related in: MedlinePlus