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Temperature and the field stability of a dengue rapid diagnostic test in the tropics.

Phommasone K, Sengvilaipaseuth O, de Lamballerie X, Vongsouvath M, Phonemixay O, Blacksell SD, Newton PN, Dubot-Pérès A - Am. J. Trop. Med. Hyg. (2015)

Bottom Line: However, in dengue-endemic areas, ambient temperatures are often higher than manufacturer's recommendation.RDTs were kept in five different conditions (at 4°C, 35°C, 45°C, 60°C, and at fluctuant ambient temperatures in a free-standing hut) for between 2 days and 2 years in the Lao People's Democratic Republic (PDR).The RDTs had 100% consistency over the 2-year study, despite high temperatures, including in the hut in which temperatures exceeded the manufacturer's recommendations for 29% of time points.

View Article: PubMed Central - PubMed

Affiliation: Microbiology Laboratory, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahosot Hospital, Vientiane, Lao People's Democratic Republic; UMR_D 190 "Emergence des Pathologies Virales" (Aix-Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health), Marseille, France; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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Monthly mean (95% confidence interval [CI]) temperatures recorded in the incubator, refrigerator, and hut over the 2-year study period, from July 23, 2012 to July 23, 2014. Empty squares are the average of daily minimum temperatures and black solid squares are the average of daily maximum temperatures recorded in the hut. D0 = day 0 (July 23, 2012), M = month.
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Figure 4: Monthly mean (95% confidence interval [CI]) temperatures recorded in the incubator, refrigerator, and hut over the 2-year study period, from July 23, 2012 to July 23, 2014. Empty squares are the average of daily minimum temperatures and black solid squares are the average of daily maximum temperatures recorded in the hut. D0 = day 0 (July 23, 2012), M = month.

Mentions: Mean monthly temperatures, with 95% confidence interval (CI), recorded in the refrigerator (4°C), in the incubators (35°C, 45°C, and 60°C), and hut are presented in Figure 4.


Temperature and the field stability of a dengue rapid diagnostic test in the tropics.

Phommasone K, Sengvilaipaseuth O, de Lamballerie X, Vongsouvath M, Phonemixay O, Blacksell SD, Newton PN, Dubot-Pérès A - Am. J. Trop. Med. Hyg. (2015)

Monthly mean (95% confidence interval [CI]) temperatures recorded in the incubator, refrigerator, and hut over the 2-year study period, from July 23, 2012 to July 23, 2014. Empty squares are the average of daily minimum temperatures and black solid squares are the average of daily maximum temperatures recorded in the hut. D0 = day 0 (July 23, 2012), M = month.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4497900&req=5

Figure 4: Monthly mean (95% confidence interval [CI]) temperatures recorded in the incubator, refrigerator, and hut over the 2-year study period, from July 23, 2012 to July 23, 2014. Empty squares are the average of daily minimum temperatures and black solid squares are the average of daily maximum temperatures recorded in the hut. D0 = day 0 (July 23, 2012), M = month.
Mentions: Mean monthly temperatures, with 95% confidence interval (CI), recorded in the refrigerator (4°C), in the incubators (35°C, 45°C, and 60°C), and hut are presented in Figure 4.

Bottom Line: However, in dengue-endemic areas, ambient temperatures are often higher than manufacturer's recommendation.RDTs were kept in five different conditions (at 4°C, 35°C, 45°C, 60°C, and at fluctuant ambient temperatures in a free-standing hut) for between 2 days and 2 years in the Lao People's Democratic Republic (PDR).The RDTs had 100% consistency over the 2-year study, despite high temperatures, including in the hut in which temperatures exceeded the manufacturer's recommendations for 29% of time points.

View Article: PubMed Central - PubMed

Affiliation: Microbiology Laboratory, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahosot Hospital, Vientiane, Lao People's Democratic Republic; UMR_D 190 "Emergence des Pathologies Virales" (Aix-Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health), Marseille, France; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Show MeSH
Related in: MedlinePlus