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Serum Albumin Concentrations in a Multi-Ethnic Cohort of Patients with Human Immunodeficiency Virus Infection from South East London.

Chong JJ, Fragaszy E, Dukes O, Cason J, Kozlakidis Z - Biores Open Access (2015)

Bottom Line: Human albumin is the most abundant protein in sera and a valuable biomarker in monitoring a variety of diseases.These were compared to a control group of untreated individuals.Based on our analyses we conclude that serum albumin concentrations increase significantly after the initiation of therapy.

View Article: PubMed Central - PubMed

Affiliation: King's College London, School of Medicine , Guy's Campus, Guy's Hospital, Great Maze Pond, London, United Kingdom .

ABSTRACT
Human albumin is the most abundant protein in sera and a valuable biomarker in monitoring a variety of diseases. In this study we investigated the relationship between serum albumin concentrations and effects of initiation of highly active antiretroviral therapy (HAART). Serum albumin concentrations amongst 70 HIV-infected patients from diverse ethnicities were analyzed, in the absence of any other confounding comorbidities, over a period of 8 years in South East London, United Kingdom. Serum albumin data was collected, on average, every 4-6 weeks during routine visits. Serum albumin was measured prior to starting HAART, and measured at the first clinic visit after commencing HAART. These were compared to a control group of untreated individuals. Based on our analyses we conclude that serum albumin concentrations increase significantly after the initiation of therapy.

No MeSH data available.


Related in: MedlinePlus

Mean serum albumin concentrations. HAART, highly active antiretroviral therapy.
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Related In: Results  -  Collection


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f1: Mean serum albumin concentrations. HAART, highly active antiretroviral therapy.

Mentions: The mean change in serum albumin between baseline and median in the untreated group was 0.24g/L (95% confidence interval [95% CI] −0.88 to 1.36), compared with pre- and post-treatment change of 2.15 g/L (95% CI 1.06 to 3.25) in the treated group. The mean change was 1.91g/L (95% CI 0.36 to 3.47) in the treated group compared with the untreated group. There was strong evidence that this change between the two time points differed between the treated and untreated groups (p=0.0166) (Fig. 1). The mean change in CD4 T-cell count between baseline and median in the untreated group was 2.16 cells/mm3 (95% CI −83.01 to 87.24), compared to pre- and post-treatment change in the treated group of 191.16 cells/mm3 (95% CI 126.57 to 255.75). Strong evidence suggests that this change between the two time points differed between the treated and untreated groups (p=0.0005) (Fig. 2).


Serum Albumin Concentrations in a Multi-Ethnic Cohort of Patients with Human Immunodeficiency Virus Infection from South East London.

Chong JJ, Fragaszy E, Dukes O, Cason J, Kozlakidis Z - Biores Open Access (2015)

Mean serum albumin concentrations. HAART, highly active antiretroviral therapy.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4497629&req=5

f1: Mean serum albumin concentrations. HAART, highly active antiretroviral therapy.
Mentions: The mean change in serum albumin between baseline and median in the untreated group was 0.24g/L (95% confidence interval [95% CI] −0.88 to 1.36), compared with pre- and post-treatment change of 2.15 g/L (95% CI 1.06 to 3.25) in the treated group. The mean change was 1.91g/L (95% CI 0.36 to 3.47) in the treated group compared with the untreated group. There was strong evidence that this change between the two time points differed between the treated and untreated groups (p=0.0166) (Fig. 1). The mean change in CD4 T-cell count between baseline and median in the untreated group was 2.16 cells/mm3 (95% CI −83.01 to 87.24), compared to pre- and post-treatment change in the treated group of 191.16 cells/mm3 (95% CI 126.57 to 255.75). Strong evidence suggests that this change between the two time points differed between the treated and untreated groups (p=0.0005) (Fig. 2).

Bottom Line: Human albumin is the most abundant protein in sera and a valuable biomarker in monitoring a variety of diseases.These were compared to a control group of untreated individuals.Based on our analyses we conclude that serum albumin concentrations increase significantly after the initiation of therapy.

View Article: PubMed Central - PubMed

Affiliation: King's College London, School of Medicine , Guy's Campus, Guy's Hospital, Great Maze Pond, London, United Kingdom .

ABSTRACT
Human albumin is the most abundant protein in sera and a valuable biomarker in monitoring a variety of diseases. In this study we investigated the relationship between serum albumin concentrations and effects of initiation of highly active antiretroviral therapy (HAART). Serum albumin concentrations amongst 70 HIV-infected patients from diverse ethnicities were analyzed, in the absence of any other confounding comorbidities, over a period of 8 years in South East London, United Kingdom. Serum albumin data was collected, on average, every 4-6 weeks during routine visits. Serum albumin was measured prior to starting HAART, and measured at the first clinic visit after commencing HAART. These were compared to a control group of untreated individuals. Based on our analyses we conclude that serum albumin concentrations increase significantly after the initiation of therapy.

No MeSH data available.


Related in: MedlinePlus