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The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer.

Brockton NT, Gill SJ, Laborge SL, Paterson AH, Cook LS, Vogel HJ, Shemanko CS, Hanley DA, Magliocco AM, Friedenreich CM - BMC Cancer (2015)

Bottom Line: Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive.These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.Recurrences are identified through medical chart abstractions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 515C, Holy Cross Centre, 2210 2nd St, SW, Calgary, AB, T2S 3C3, Canada. nigel.brockton@albertahealthservices.ca.

ABSTRACT

Background: Bone is the most common site of breast cancer distant metastasis, affecting 50-70 % of patients who develop metastatic disease. Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive. The Breast Cancer to Bone (B2B) Metastases Research Program consists of a prospective cohort of incident breast cancer patients and four sub-projects that are investigating priority areas in breast cancer bone metastases. These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.

Methods/design: The B2B Research Program is enrolling a prospective cohort of 600 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a five year period. At baseline, pre-treatment/surgery blood samples are collected and detailed epidemiologic data is collected by in-person interview and self-administered questionnaires. Additional self-administered questionnaires and blood samples are completed at specified follow-up intervals (24, 48 and 72 months). Vital status is obtained prior to each follow-up through record linkages with the Alberta Cancer Registry. Recurrences are identified through medical chart abstractions. Each of the four projects applies specific methods and analyses to assess the impact of serum vitamin D and cytokine concentrations, tumour transcript and protein expression, serum metabolomic profiles and in vitro cell signalling on breast cancer bone metastases.

Discussion: The B2B Research Program will address key issues in breast cancer bone metastases including the association between lifestyle factors (particularly a comprehensive assessment of vitamin D status) inflammation and bone metastases, the significance or primary tumour gene expression in tissue tropism, the potential of metabolomic profiles for risk assessment and early detection and the signalling pathways controlling the metastatic tumour microenvironment. There is substantial synergy between the four projects and it is hoped that this integrated program of research will advance our understanding of key aspects of bone metastases from breast cancer to improve the prevention, prediction, detection, and treatment of these lesions.

No MeSH data available.


Related in: MedlinePlus

Ascertainment recruitment, data and biospecimen collection and sharing scheme. Newly diagnosed cancer patients are identified through the ACR, and are invited to donate biospecimen samples by the ACRB utilizing the CoBRA infrastructure. Clinical data and biospecimens are stored by the ACRB, and contact information from eligible and consenting participants is sent to study coordinators of relevant research programs. Subsequent blood samples and blood questionnaire data for routine study follow-up are collected by the ACRB and act as a shared resource between the biorepository and research study team
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Fig3: Ascertainment recruitment, data and biospecimen collection and sharing scheme. Newly diagnosed cancer patients are identified through the ACR, and are invited to donate biospecimen samples by the ACRB utilizing the CoBRA infrastructure. Clinical data and biospecimens are stored by the ACRB, and contact information from eligible and consenting participants is sent to study coordinators of relevant research programs. Subsequent blood samples and blood questionnaire data for routine study follow-up are collected by the ACRB and act as a shared resource between the biorepository and research study team

Mentions: Patients with incident primary breast cancer are eligible for recruitment into the B2B Cohort if they meet the following criteria as determined through the CoBRA database: (1) histologically-confirmed stage I to stage IIIc breast cancer diagnosed between 2010 and 2015; (2) residents of Calgary, Alberta and the surrounding areas; (3) females ≥18 and ≤80 years at initial diagnosis; (4) able to provide informed, written consent and complete questionnaires and an in-person interview in English; and, (5) no previous cancer diagnosis with the exception of cervical in-situ neoplasia (CIN) and non-melanoma skin cancer. Cohort participants must have donated a pre-surgical blood sample to the ACRB (Fig. 3) and indicated willingness to be contacted for future research. The contact details of eligible patients are then exported to the B2B Research Program database for recruitment into the B2B Cohort. The B2B Cohort is restricted to the Calgary area because of the feasibility of processing blood samples collected from community laboratories within 24 h.Fig. 3


The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer.

Brockton NT, Gill SJ, Laborge SL, Paterson AH, Cook LS, Vogel HJ, Shemanko CS, Hanley DA, Magliocco AM, Friedenreich CM - BMC Cancer (2015)

Ascertainment recruitment, data and biospecimen collection and sharing scheme. Newly diagnosed cancer patients are identified through the ACR, and are invited to donate biospecimen samples by the ACRB utilizing the CoBRA infrastructure. Clinical data and biospecimens are stored by the ACRB, and contact information from eligible and consenting participants is sent to study coordinators of relevant research programs. Subsequent blood samples and blood questionnaire data for routine study follow-up are collected by the ACRB and act as a shared resource between the biorepository and research study team
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4496930&req=5

Fig3: Ascertainment recruitment, data and biospecimen collection and sharing scheme. Newly diagnosed cancer patients are identified through the ACR, and are invited to donate biospecimen samples by the ACRB utilizing the CoBRA infrastructure. Clinical data and biospecimens are stored by the ACRB, and contact information from eligible and consenting participants is sent to study coordinators of relevant research programs. Subsequent blood samples and blood questionnaire data for routine study follow-up are collected by the ACRB and act as a shared resource between the biorepository and research study team
Mentions: Patients with incident primary breast cancer are eligible for recruitment into the B2B Cohort if they meet the following criteria as determined through the CoBRA database: (1) histologically-confirmed stage I to stage IIIc breast cancer diagnosed between 2010 and 2015; (2) residents of Calgary, Alberta and the surrounding areas; (3) females ≥18 and ≤80 years at initial diagnosis; (4) able to provide informed, written consent and complete questionnaires and an in-person interview in English; and, (5) no previous cancer diagnosis with the exception of cervical in-situ neoplasia (CIN) and non-melanoma skin cancer. Cohort participants must have donated a pre-surgical blood sample to the ACRB (Fig. 3) and indicated willingness to be contacted for future research. The contact details of eligible patients are then exported to the B2B Research Program database for recruitment into the B2B Cohort. The B2B Cohort is restricted to the Calgary area because of the feasibility of processing blood samples collected from community laboratories within 24 h.Fig. 3

Bottom Line: Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive.These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.Recurrences are identified through medical chart abstractions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 515C, Holy Cross Centre, 2210 2nd St, SW, Calgary, AB, T2S 3C3, Canada. nigel.brockton@albertahealthservices.ca.

ABSTRACT

Background: Bone is the most common site of breast cancer distant metastasis, affecting 50-70 % of patients who develop metastatic disease. Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive. The Breast Cancer to Bone (B2B) Metastases Research Program consists of a prospective cohort of incident breast cancer patients and four sub-projects that are investigating priority areas in breast cancer bone metastases. These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.

Methods/design: The B2B Research Program is enrolling a prospective cohort of 600 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a five year period. At baseline, pre-treatment/surgery blood samples are collected and detailed epidemiologic data is collected by in-person interview and self-administered questionnaires. Additional self-administered questionnaires and blood samples are completed at specified follow-up intervals (24, 48 and 72 months). Vital status is obtained prior to each follow-up through record linkages with the Alberta Cancer Registry. Recurrences are identified through medical chart abstractions. Each of the four projects applies specific methods and analyses to assess the impact of serum vitamin D and cytokine concentrations, tumour transcript and protein expression, serum metabolomic profiles and in vitro cell signalling on breast cancer bone metastases.

Discussion: The B2B Research Program will address key issues in breast cancer bone metastases including the association between lifestyle factors (particularly a comprehensive assessment of vitamin D status) inflammation and bone metastases, the significance or primary tumour gene expression in tissue tropism, the potential of metabolomic profiles for risk assessment and early detection and the signalling pathways controlling the metastatic tumour microenvironment. There is substantial synergy between the four projects and it is hoped that this integrated program of research will advance our understanding of key aspects of bone metastases from breast cancer to improve the prevention, prediction, detection, and treatment of these lesions.

No MeSH data available.


Related in: MedlinePlus